Effects of treatment with gonadotropin releasing hormone agonist on the uterine leiomyomata structure

Bozzini, Nilo; Rodrigues, Consuelo Junqueira; Petti, Domingos Auricchio; Bevilacqua, Ruy Geraldo; Gonçalves, S.P.; Pinotti, José Aristodemo

doi:10.1034/j.1600-0412.2003.00049.x

Cited by 20 publications

(7 citation statements)

References 15 publications

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“…A few descriptive studies have evaluated the expression of Ki‐67 and endothelial cell marker CD31 in fibroids, with no reference to tumor size. Other morphological features, such as smooth muscle cell density and collagen content, have been examined, mainly in the evaluation of response to GnRHa, with contradictory results. A single study has attempted to predict clinical growth of fibroids by means of histological examination of fibroid biopsies and magnetic resonance imaging.…”

Section: Discussionmentioning

confidence: 99%

Does three‐dimensional power Doppler ultrasound predict histopathological findings of uterine fibroids? A preliminary study

Minsart

Šíma

VandenHoute

et al. 2012

Ultrasound in Obstet & Gyne

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Section: Discussionmentioning

confidence: 99%

Does three‐dimensional power Doppler ultrasound predict histopathological findings of uterine fibroids? A preliminary study

Minsart

Šíma

VandenHoute

et al. 2012

Ultrasound in Obstet & Gyne

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“…GnRHa undoubtedly induce fibroid tumor shrinkage, the degree of which has been shown to be directly proportional to the percentage of cells that are estrogen receptor positive, thus implicating estrogen as a major effector of tumor growth and its reduction as the central mechanism of fibroid shrinkage with GnRHa therapy 78. Chegini et al found evidence of suppression of signal transduction pathways involving growth factors, ovarian steroids, and adhesion molecules with a resulting decrease in DNA synthesis, cell proliferation, and production of transforming growth factor-b 79,80.…”

Section: Managementmentioning

confidence: 99%

Uterine fibroids: current perspectives

Khan¹,

Shehmar²,

Gupta³

2014

IJWH

307

252

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Uterine fibroids are a major cause of morbidity in women of a reproductive age (and sometimes even after menopause). There are several factors that are attributed to underlie the development and incidence of these common tumors, but this further corroborates their relatively unknown etiology. The most likely presentation of fibroids is by their effect on the woman’s menstrual cycle or pelvic pressure symptoms. Leiomyosarcoma is a very rare entity that should be suspected in postmenopausal women with fibroid growth (and no concurrent hormone replacement therapy). The gold standard diagnostic modality for uterine fibroids appears to be gray-scale ultrasonography, with magnetic resonance imaging being a close second option in complex clinical circumstances. The management of uterine fibroids can be approached medically, surgically, and even by minimal access techniques. The recent introduction of selective progesterone receptor modulators (SPRMs) and aromatase inhibitors has added more armamentarium to the medical options of treatment. Uterine artery embolization (UAE) has now been well-recognized as a uterine-sparing (fertility-preserving) method of treating fibroids. More recently, the introduction of ultrasound waves (MRgFUS) or radiofrequency (VizAblate™ and Acessa™) for uterine fibroid ablation has added to the options of minimal access treatment. More definite surgery in the form of myomectomy or hysterectomy can be performed via the minimal access or open route methods. Our article seeks to review the already established information on uterine fibroids with added emphasis on contemporary knowledge.

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“…Besides a reduction of size, increased cellularity, necrosis, decreased cell volume, atrophy, diminished microfilaments, mitochondrial swelling, pyknosis, and cellular deformity are also reported [10][11][12][13]. In leiomyomas without lymphoid infiltration, modulation of the reactivity of progesterone and estrogen receptors is detected as well [14]. In our case, the alterations were observed mainly in the reactivity of leiomyocytes for LAMPs.…”

Section: Discussionmentioning

confidence: 48%

Uterine leiomyoma with massive lymphoid infiltrate after colon cancer chemotherapy: an immunohistochemical investigation with special reference to lysosome-associated membrane protein expression

Belovejdov

Dikov²,

Auriault³

et al. 2009

Open Medicine

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AbstractUterine leiomyoma with massive lymphoid infiltration is a rare morphologic phenomenon. We describe the first case of uterine leiomyoma with lymphoid infiltration observed in a patient after chemotherapy for sigmoid cancer. We performed immunohistochemical analysis with a panel of antibodies to several markers. Detection of CD20, CD3, Ki67, CD68 and Epstein-Barr virus nuclear antigen assisted in the differential diagnosis and partial elucidation of the pathogenesis. In addition, we examined the lysosome-associated membrane proteins LAMP-1 and LAMP-2 for the first time in this lesion. Their expression was elevated, indicating enhanced autophagy, an indirect sign of degenerative changes in this benign tumor characterized by massive lymphoid infiltration.

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Effects of treatment with gonadotropin releasing hormone agonist on the uterine leiomyomata structure

Abstract: Our data strengthen the hypothesis that the uterine leiomyoma response to steroid hormones results from the presence of specific hormone receptors, and progesterone receptors may also play a role in the development of leiomyoma.

Cited by 20 publications

References 15 publications

Does three‐dimensional power Doppler ultrasound predict histopathological findings of uterine fibroids? A preliminary study

Does three‐dimensional power Doppler ultrasound predict histopathological findings of uterine fibroids? A preliminary study

Uterine fibroids: current perspectives

Uterine leiomyoma with massive lymphoid infiltrate after colon cancer chemotherapy: an immunohistochemical investigation with special reference to lysosome-associated membrane protein expression

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