Effects of treatment with once-daily nifedipine CR and twice-daily benidipine on prevention of symptomatic attacks in patients with coronary spastic angina pectoris—Adalat Trial vs Coniel in Tokyo against Coronary Spastic Angina (ATTACK CSA)

Abstract

Once-daily treatment with NR 40 mg was more effective than twice-daily treatment with BD in the prevention of CSA attacks.

An autopsy case of tako-tsubo cardiomyopathy presenting ventricular tachycardia after pacemaker implantation

“…It has been reported that nifedipine CR has inhibitory effects on symptomatic attacks in patients with vasospastic angina [5]. Our patient was treated with nifedipine CR for hypertension.…”

Increased frequency of angina attacks caused by switching a brand-name vasodilator to a generic vasodilator in patients with vasospastic angina: Two case reports

“…In such cases, we follow several courses of action. First, we must consider the type of CCB, because CCBs may differ in their ability to prevent angina attacks[ 10 , 11 ]. Second, we must consider the dosing regimen, such as whether a submaximal or maximal dose or medication once or twice a day would be appropriate.…”

Potential Treatments for Refractory Vasospastic Angina

“…Thus, if one CCB is not effective in treating VSA angina, several counter parts should be considered 18) . The following recommendations during CCB use might be helpful for refractory or intolerant cases: 1) A change or combination in the CCB type (dihydropyridine CCB and non-dihydropyridine CCB) 32,33) , 2) higher-dose CCBs than submaximal or maximal dose/once or twice a day 10) (verapamil or diltiazem 960 mg/day and/or nifedipine 100 mg/day and nitrates [34][35][36] ), 3) change from once-a-day CCB to twice a day to prevent the attacks just before the dosing time, 4) prescribing CCB at bed time to prevent attacks between midnight and early morning 14,37) , and 5) an occasional switching from generic CCBs to branded ones 38) . Nitrates…”