Effective patient counseling is an important aspect in healthcare which helps the patient to understand the treatment, comply with it and helps in better health outcomes. This review highlights the therapeutic alliance which is based on compassion, cultural respect, attentive to patient needs and imparting education to the patient. Communication between the patient and the healthcare provides an important aspect where the medical language is simplified and the patient understands the diagnosis and treatment provided. When a healthcare provider empathizes with the patient, the patient builds trust and is willing to divulge other important aspects of their health which increases satisfaction and compliance in the care regimen. Besides that, active listening techniques support the patients' worthiness and equity in communication which helps to reinforce the patients’ clarification abilities. Cultural competence plays a central role in meeting the various challenges of patient care by respecting their values and health beliefs. The use of customized educational resources such as brochures, video clips and educational games encourages patient’s participation in making active decisions regarding their health care. Nevertheless, time constraints and patient overflow may hamper the level of counseling that is provided. There is a need for continuing education to ensure that the health providers are trained on appropriate communication and counseling techniques. Most importantly, development of health systems that champion effective communication, compassion and respect for diversity with patients will improve health outcomes, patient satisfaction and adherence to treatment.