Effects of trimetazidine on anticancer activity and toxicity of abraxane in MCF-7 breast cancer cells

Şekeroğlu, Zülal Atlı; Kendigelen, Emre; Şekeroğlu, Vedat; Küçük, Nihan

doi:10.1007/s12210-022-01100-w

Cited by 4 publications

(1 citation statement)

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“…TMZ can be used alone or in combination with antineoplastic drugs, such as gemcitabine or abraxane, to reduce cell viability and induce apoptosis in human pancreatic cancer cells [165]. Additionally, the derivative of compound 93 also induced cell death in breast cancer cells [166].…”

Section: Pyridazine and Piperazinementioning

confidence: 99%

Unmasking the Warburg Effect: Unleashing the Power of Enzyme Inhibitors for Cancer Therapy

Angulo-Elizari,

Gaviria-Soteras,

Zubiri

et al. 2023

DDC

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The Warburg effect (or aerobic glycolysis), which was first described in 1926 by Otto Heinrich Warburg, consists of the change in glucose metabolism in cancer cells. In normal cells, glucose metabolism finalizes in the mitochondria through oxidative phosphorylation (OXPHOS) in the presence of oxygen. However, the Warburg effect describes a change in the glucose metabolism in cancer cells, consuming excess glucose and converting it into lactate independently of the presence of oxygen. During this process, a wide variety of enzymes can modify their expression and activity to contribute to the mechanism of deregulated cancer metabolism. Therefore, the modulation of enzymes regulating aerobic glycolysis is a strategy for cancer treatment. Although numerous enzymes play a role in regulating aerobic glycolysis, hexokinase 2 (HK2), pyruvate dehydrogenase kinase (PDK), pyruvate kinase (PK), and lactate dehydrogenase (LDH) are worth mentioning. Numerous modulators of these enzymes have been described in recent years. This review aims to present and group, according to their chemical structure, the most recent emerging molecules targeting the above-mentioned enzymes involved in the Warburg effect in view of the future development of cancer treatments.

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Section: Pyridazine and Piperazinementioning

confidence: 99%