Effects of trimetazidine on crush injury of the sciatic nerve in rats: A biochemical and stereological study

Serarslan, Yurdal; Bal, Ramazan; Altuğ, Muhammed Enes; Kontaş, Tünay; Keleş, Osman Nuri; Ünal, Deniz; Ünal, Bünyami

doi:10.1016/j.brainres.2008.10.007

Cited by 23 publications

(22 citation statements)

References 33 publications

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“…Recently, some reports indicate the neuroprotective effects of trimetazidine in various experimental models. These effects have been suggested to be due to its antioxidant property (Mironovan et al 2001;Dhote and Balaraman 2008;Serarslan et al 2009). Baltalarli et al (2000) and Iqbal et al (2002) showed that administration of trimetazidine during the period of ischemia-reperfusion injury reduced the number of damaged cells in cerebral tissue and preserved neurological function in transient global ischemia model in rats and gerbils, respectively.…”

Section: Introductionmentioning

confidence: 95%

Anticonvulsant and antioxidant actions of trimetazidine in pentylenetetrazole-induced kindling model in mice

Jain

Bharal

Khurana

et al. 2011

Naunyn-Schmied Arch Pharmacol

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The present study was carried out to investigate the effect of trimetazidine on the course of pentylenetetrazole (PTZ)-induced chemical kindling and oxidative stress markers in PTZ-kindled mice. Kindling was induced by repeated injections of a subconvulsive dose of PTZ (30 mg⁄kg, i.p.) on alternate days for 5 weeks or until stage 4 of the seizure score was evoked on three consecutive administrations. Trimetazidine was administered daily in three doses (5, 10 and 20 mg/kg) per orally (p.o.) along with alternate-day PTZ. Following PTZ kindling, oxidative stress parameters, i.e. levels of malondialdehyde (MDA) and reduced glutathione (GSH), were assessed in isolated homogenized whole brain tissue. The results showed that PTZ treatment progressively increased the seizure score in control mice. Biochemical analysis revealed a significant increase in MDA levels and decreased GSH levels in the brain homogenate of PTZ-kindled mice. Daily treatment with trimetazidine in doses of 10 and 20 mg/kg significantly decreased the PTZ-induced seizure score. However, a low dose of trimetazidine (5 mg/kg) failed to improve the seizure score. Pretreatment of trimetazidine in all doses showed an ameliorating effect on biochemical alteration induced by PTZ treatment. The results of the present study indicate the potential anticonvulsant activity of trimetazidine against PTZ-induced kindling in mice.

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Section: Introductionmentioning

confidence: 95%

Anticonvulsant and antioxidant actions of trimetazidine in pentylenetetrazole-induced kindling model in mice

Jain

Bharal

Khurana

et al. 2011

Naunyn-Schmied Arch Pharmacol

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“…A strong relationship has been reported between neuroprotective treatment and antioxidant enzyme activities in many types of neural tissue insults. [13][14][15] To our knowledge, there has been no study investigating the neuroprotective effects of tadalafil (a selective long-acting PDE5 inhibitor) on traumatic SCI. The present study was conducted to investigate and compare the effects of methylprednisolone and tadalafil on the antioxidant enzyme activities of glutathione peroxidase (GSH-Px; EC 1.6.4.2) and superoxide dismutase (SOD; EC 1.15.1.1) and the levels of NO and malondialdehyde (MDA) in serum and/or tissue after experimental SCI in rats.…”

Section: Introductionmentioning

confidence: 97%

Protective effects of tadalafil on experimental spinal cord injury in rats

Serarslan

Yönden

Özgiray

et al. 2010

Journal of Clinical Neuroscience

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“…The rats were kept under a 12 h light/dark cycle (light from 07.00 to 19.00), in quiet rooms, with [22][23][24] o C ambient temperature and provided free access to standard rat nutrients and purified drinking water ad libitum.…”

Section: Methodsmentioning

confidence: 99%

“…TMZ has been shown in experimental animal models to be beneficial against ischemia in several organs including the heart and the brain, peripheral nerves, inner ear, kidney, lung, bowel, liver, and stomach [15][16][17][18][19][20][21][22] . Despite the clearly-defined antiischemic effects of the TMZ, there are a limited number of studies in the literature on the potential effects of TMZ in epileptic seizures or convulsions 10,23 .…”

Section: Introductionmentioning

confidence: 99%

Acute Administration of High Dose Trimetazidine Inhibits Pentylenetetrazol-Induced Seizures in Rats

Gürgül¹,

Erten

Gül³

et al. 2017

Cumhuriyet Medical Journal

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SUMMARYObjective: Resistant epilepsy is widely seen in clinical settings manipulate the researchers to pursuit novel anti-epileptic treatments. Although trimetazidine (TMZ) is commonly used in the treatment of angina and ischemic diseases, it is considered that the drug may be beneficial in the treatment of epileptic seizures and convulsions. We aimed to evaluate electrophysiologically the protective effects of high dose acute TMZ on epileptic seizures and convulsions in a rat model of epilepsy induced by pentilentetrazol (PTZ). Method: Forty-eight male Sprague-Dawley rats were used for the EEG evaluation (Group-A; n=24) and behavioral assessment (Group-B; n=24). Grup-A1 and Grup-B1 were determined as control group and given no medication. 35 mg/kg (Group-A2, -A3 and -A4) and 70 mg/kg (Group-B2, -B3 and -B4) of PTZ were administered intraperitoneally (ip.) so as to generate seizures and convulsions. Group-A2 and Group-B2 were treated with saline. 40 mg/kg (Grup-A3 and Grup-B3) and 80 mg/kg of TMZ (Group-A4 and Group-B4) were administered to the treatment groups by ip. Brain malondialdehyde (MDA) levels, spike-percentage values, Racine's Convulsion Scale (RCS) scores and "first myoclonic jerk (FMJ)" latencies of each rat were determined. Results: Brain MDA levels, spike-percentage values, RCS scores, and FMJ latencies of Group-A2 and Group-B2 were significantly increased compared to those of the control's (Grup-A1 and Grup-B1) (P<0.05 for all comparisons). However, in TMZ treated groups (Group-A3 and -A4; Group-B3 and -B4) the elevated values of these parameters were found to be significantly decreased (P<0.05 for all comparisons). Conclusions:This study has demonstrated that the high dose acute TMZ administration may prevent PTZ-induced seizures and convulsions in rats. Furthermore, it can be also said that TMZ has a neuroprotective effects on oxidative stress associated with PTZ. Therefore, it may be considered for use with therapeutic purposes of TMZ in resistant epilepsy patients in the future. Keywords: Electroencephalography (EEG), Epilepsy, Malondialdehyde, Pentylenetetrazol, Rat, Trimetazidine.ÖZET Amaç: İlaca-dirençli epilepsi, klinikte yaygın olarak görülen ve araştırmacıları yeni anti-epileptik tedavilerin saptanması için harekete geçiren bir durumdur. Trimetazidin (TMZ) anjina ve iskemik hastalıkların tedavisinde yaygın olarak kullanılmasına rağmen, epileptik nöbetler ve konvülsiyonların tedavisinde de yararlı olabileceği düşünülmektedir. Bu çalışmada, pentilentetrazol (PTZ) ile indüklenen bir sıçan epilepsi modelinde yüksek doz akut TMZ'nin epileptik nöbetler ve konvülsiyonlar üzerine koruyucu etkilerini elektrofizyolojik parametreler açısından değerlendirmeyi amaçladık. 381Yöntem: 48 adet erkek Sprague-Dawley cinsi sıçan EEG (Group-A; n=24) ve davranış analizlerinde (Group-B; n=24) kullanıldı. Grup-A1 ve Grup-B1 kontrol grubu olarak belirlendi ve ilaç verilmedi. 35 mg/kg (Group-A2, -A3 ve -A4) ve 70 mg/kg PTZ (Group-B2, -B3 ve -B4), nöbet ve konvülsiyon oluşturmak amacıyla, intraperitoneal olarak (i...

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Effects of trimetazidine on crush injury of the sciatic nerve in rats: A biochemical and stereological study

Cited by 23 publications

References 33 publications

Anticonvulsant and antioxidant actions of trimetazidine in pentylenetetrazole-induced kindling model in mice

Anticonvulsant and antioxidant actions of trimetazidine in pentylenetetrazole-induced kindling model in mice

Protective effects of tadalafil on experimental spinal cord injury in rats

Acute Administration of High Dose Trimetazidine Inhibits Pentylenetetrazol-Induced Seizures in Rats

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