Effects of Triphenyltin Acetate on Survival, Hatching Success, and Liver Ultrastructure of Early Life Stages of Zebrafish (Danio rerio)

Strmac, Marija; Braunbeck, Thomas

doi:10.1006/eesa.1999.1781

Cited by 69 publications

(33 citation statements)

References 60 publications

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“…The aforementioned morphological finding indicated a series of lesions in fish liver cells, which actually confirmed severe damage of MeHg and selenium to fish livers and ulteriorly influenced normal physiological activities. The result was fairly in agreement with those of other reports (Strmac and Braunbeck, 1999;Zaroogian et al, 2001). II.…”

Section: Histological Observationsupporting

confidence: 94%

Interaction of methylmercury and selenium on the bioaccumulation and histopathology in medaka (Oryzias latipes)

Liao

Zhou

et al. 2007

Environmental Toxicology

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Interaction of methylmercury and selenium in medaka (Oryzias latipes) on bioaccumulation of pollutants and histopathological changes in liver and gill were studied. Juvenile medaka fish were submitted to a series of waterborne methylmercury chloride (MMC), sodium selenite (Na 2 SeO 3 ) and their mixture for 210 days, respectively. The methylmercury (MeHg) and selenium contents in the whole body of medaka were determined. The dose-and time-dependent increase of MeHg and selenium contents in medaka were observed. Histopathological changes, such as edema, vacuoles, pyknotic nucleus, and telangiectasis, could clearly be observed in the slices from the exposed medaka's liver and gill. Concurrent exposure to MMC and Na 2 SeO 3 showed the increased selenium accumulation. When the exposure molar ratio of MeHg:Se was about 1, the interaction between MeHg and selenium offered a limited protection against the serious intoxication of both MMC and Na 2 SeO 3 to medaka. # 2007 Wiley Periodicals, Inc. Environ Toxicol 22: 69-77, 2007.

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Section: Histological Observationsupporting

confidence: 94%

Interaction of methylmercury and selenium on the bioaccumulation and histopathology in medaka (Oryzias latipes)

Liao

Zhou

et al. 2007

Environmental Toxicology

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“…Ocular and morphological malformations have been observed in embryos and larvae of European minnows (Phoxinus phoxinus) and zebrafish (Danio rerio) after in ovo exposure of TPT (12,13) and in the offspring of medaka (Oryzias latipes) maternally exposed to TBT and TPT (14,15). Also, TBT and TPT can inhibit reproduction (14,15).…”

mentioning

confidence: 99%

Malformations of the endangered Chinese sturgeon, Acipenser sinensis , and its causal agent

Zhang

Wei

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

122

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The anadromous Chinese sturgeon (Acipenser sinensis) is endangered and listed among the first class of protected animals in China. The possible causes for the decline of this species are the effects of synthetic chemicals, and loss of critical habitat. Chinese sturgeon in the Yangtze River have accumulated triphenyltin (TPT) to 31-128 ng/g wet weigh (ww) in liver, which is greater than the concentrations of tributyltin (<1.0 ng/g ww). Maternal transfer of TPT has resulted in concentrations of 25.5 ؎ 13.0 ng/g ww in eggs of wild Chinese sturgeon, which poses a significant risk to the larvae naturally fertilized or hatched in the Yangtze River. The incidence of deformities in fry was 7.5%, with 1.2% of individuals exhibiting ocular abnormal development, and 6.3% exhibited skeletal/morphological deformations. The incidences of both ocular and skeletal/morphological deformations were directly proportional to the TPT concentration in the eggs of both the Chinese sturgeon and the Siberian sturgeon (Acipenser baerii) in controlled laboratory studies. The rates of deformities in the controlled studies were consistent with the rates caused at the similar concentrations in eggs collected from the field. Thus, TPT is the causal agent to induce the malformation of larvae of Chinese sturgeon. The incidence of deformed larvae of Chinese sturgeon is an indicator of overall population-level effects of TPT on Chinese sturgeon, because TPT at environmentally relevant concentrations can result in significantly decrease both quality and quantity of eggs and spawning frequency of fish.teratogenesis ͉ fish ͉ triphenyltin ͉ Yangtze River

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“…There were no larval abnormalities in the controls. The malformations observed can be classed as relatively unspecific responses to a number of pollutants (Strmac and Braunbeck, 1999). The percentage of larval abnormalities increased in accordance with Aroclor 1254 concentration (Fig.…”

Section: Larvae Toxicity Of Aroclor 1254mentioning

confidence: 83%

Toxicological Efects of Aroclor 1254 on the Embryonic Development of the Olive Flounder Paralichthys olivaceus

Min¹,

Kang²

2013

Fisheries and aquatic sciences

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We investigated the toxicological effects of Aroclor 1254 on the fertilized eggs, embryos and larvae of the olive flounder Paralichthys olivaceus. The survival rate and hatching success of the embryos decreased significantly in treated groups in an Aroclor 1254-dose-dependent manner. Significant differences were found at ≥5 µg/L Aroclor 1254 compared to the control group. Hatching success occurred at ≤10 µg/L Aroclor 1254, which was not significantly different to the control. Embryo malformation increased significantly at ≥1 µg/L, and included yolk-sac and tail-flexure abnormalities. There was a significant decrease in the survival rate of the larvae at ≥5 µg/L, which was accompanied by the malformations described above. Notably, concentrations as low as 1 µg/L caused a significant increase in abnormalities in the larvae, including incidences of multi-focal hemorrhages, pericardial and yolk-sac edema, inhibition of swim bladder inflation and severe developmental delay. The responses to Aroclor 1254-induced toxicity were generally similar among fertilized eggs, embryos and larvae from three separate flounder hatcheries: Cheju Island, Yeosu and Chungnam, South Korea. These results indicate the high acute toxicity of Arolcor 1254 concentrations of which as low as 1 μg/L in olive flounder larvae can affect unhatched embryos. To conclude, the average LC 50 values for Aroclor 1254 in the embryos and larvae were 50.92 and 3.08 μg/L, respectively. Additionally, the average EC 50 values, based on the rate of damage were 14.72 and 5.61 μg/L, respectively.

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Effects of Triphenyltin Acetate on Survival, Hatching Success, and Liver Ultrastructure of Early Life Stages of Zebrafish (Danio rerio)

Cited by 69 publications

References 60 publications

Interaction of methylmercury and selenium on the bioaccumulation and histopathology in medaka (Oryzias latipes)

Interaction of methylmercury and selenium on the bioaccumulation and histopathology in medaka (Oryzias latipes)

Malformations of the endangered Chinese sturgeon, Acipenser sinensis , and its causal agent

Toxicological Efects of Aroclor 1254 on the Embryonic Development of the Olive Flounder Paralichthys olivaceus

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