Effects of tumors on the daily mitotic activity of mouse pars intermedia

Surur, J. M.; Catalano, Vicente Alberto; Flamini, Mirta Alicia; Barbeito, Claudio Gustavo

doi:10.1016/j.cellbi.2004.11.017

Cited by 2 publications

(2 citation statements)

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“…These findings suggest that the chronic effect caused by a grafted tumor may result opposed to the acute action exerted by the same neoplasia extract injection. However, the stimulating effect promoted by EA21 tumor graft has not been found in other cell populations, such as pars intermedia cells (Surur et al 2005).…”

Section: Discussionmentioning

confidence: 97%

Antimitotic activity of EA21b mammary-carcinoma extract

2007

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Many tumors produce factors that affect cell-cycle and cell proliferation. In the present study we have analyzed the effect of a mammary-tumor extract injection on the mitotic activity of several organs in young male C3H/S mice previously standardized for circadian periodicity. One-half of the animals received an intraperitoneal EA21b tumor extract dose at 16:00 h, while the other half received saline. Animals were sacrificed on the following day at 08:00, 12:00 or 16:00 h, 4 h after receiving an injection of colchicine by the same route. Samples of duodenum, kidney, liver, and submaxillary gland were excised and processed for hematoxylin-eosin staining. Mitotic indices, expressed as the number of colchicine-arrested metaphases per 1,000 nuclei, were assessed in convoluted tubule epithelium, duodenal crypt enterocytes, hepatocytes and submaxillary gland ductal and acinar sialocytes. All values were expressed as mean ± SEM. Statistical analyses were performed by ANOVA, Bonferroni and Student's t-tests. In contrast to the mitotic indices reductions observed in renal convoluted tubules cells and duodenal crypt enterocytes, neither the submaxillary gland nor the liver were found to contain cell types whose mitotic activity was affected by the tumor extract. We conclude that EA21b mammary carcinoma contains one or more factors that inhibit the proliferation of selected populations of normal cells.

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Section: Discussionmentioning

confidence: 97%

Antimitotic activity of EA21b mammary-carcinoma extract

2007

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“…В разные годы опубликовано несколько работ, в которых показано снижение уровня пролиферации [57] или нарушение ритма пролиферации в тощей кишке [58,59] мышей с опухолями. Также было показано негативное влияние опухолей на ритм пролиферации pars intermedia гипофиза [60]. Нарушение ритма экспрессии генов, пролиферации и других процессов в неопухолевых тканях может быть связано с повреждением ДНК, вызванным системным воспалительным ответом и оксидативным стрессом.…”

Section: влияние опухолевого процесса на циркадианные ритмы во всем организмеunclassified

Review of Research on the Relationship Between Circadian Rhythms and Carcinogenesis Using Animal Models

et al. 2021

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Purpose of the study: to review in vivo studies on the relationship and role of various molecular genetic components of the circadian rhythm system in the initiation and development of malignant neoplasms. in contrast to clinical and epidemiological studies, animal models, including transgenic animal models, can model various changes and disturbances in the activity of clock genes and track the results of these changes.Material and Methods. the review includes data from studies carried out over the past 10 years in animal models, studying the mechanisms and effects of disturbances in the system of circadian rhythms related to the formation and development of tumors. the data sources for the review were the Medline, embase and scopus databases.Results. analysis of the literature has shown that interference with the work of the «biological clock» by changing the light cycle, disrupting the expression of clock genes and other manipulations is a factor predisposing to the development of tumors. in tumors of various types, the expression of clock genes is often mismatched, and it is unclear at what stage of their formation this occurs. in addition, the development of tumors disrupts the circadian homeostasis of the body. there are three key areas of research aimed at studying the role of circadian rhythms in tumor development: disturbance of circadian rhythms as a carcinogenic factor, disturbances in the clock gene system in a tumor, disturbances in the clock gene system of the whole organism, provoked by tumor development.Conclusion. the results of studies on animal models demonstrate that the relationship between the disturbance of circadian rhythms and the tumor process is complex since the causal relationship has not yet been studied. in this regard, the prospect of targeted pharmacological correction of circadian rhythms in clinical practice in cancer patients does not seem to be the nearest one.

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Effects of tumors on the daily mitotic activity of mouse pars intermedia

Cited by 2 publications

References 8 publications

Antimitotic activity of EA21b mammary-carcinoma extract

Antimitotic activity of EA21b mammary-carcinoma extract

Review of Research on the Relationship Between Circadian Rhythms and Carcinogenesis Using Animal Models

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