Effects of two different exercise programs on gait parameters in individuals with Parkinson's disease: A pilot study

Ayán, Carlos; Cancela, José M.; Gutiérrez-Santiago, Alfonso; Prieto, Iván Núñez

doi:10.1016/j.gaitpost.2013.08.019

Cited by 32 publications

(18 citation statements)

References 12 publications

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“…1E ) and the rotarod test (Fig. 1D ) were improved gradually after exercise, which indicated that exercise improves kinematics and motor coordination in PD animals, findings which are in accord with previous publications 29 , 30 .…”

Section: Discussionsupporting

confidence: 91%

Exercise Ameliorates Motor Deficits and Improves Dopaminergic Functions in the Rat Hemi-Parkinson’s Model

Chen

Kuo

Kao

et al. 2018

Sci Rep

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To determine the influences of exercise on motor deficits and dopaminergic transmission in a hemiparkinson animal model, we measured the effects of exercise on the ambulatory system by estimating spatio-temporal parameters during walking, striatal dopamine (DA) release and reuptake and synaptic plasticity in the corticostriatal pathway after unilateral 6-OHDA lesions. 6-OHDA lesioned hemiparkinsonian rats were exercised on a fixed speed treadmill for 30 minutes per day. Controls received the same lesion but no exercise. Animals were subsequently analyzed for behavior including gait analysis, rotarod performance and apomorphine induced rotation. Subsequently, in vitro striatal dopamine release was analyzed by using FSCV and activity-dependent plasticity in the corticostriatal pathway was measured in each group. Our data indicated that exercise could improve motor walking speed and increase the apomorphine-induced rotation threshold. Exercise also ameliorated spatiotemporal impairments in gait in PD animals. Exercise increased the parameters of synaptic plasticity formation in the corticostriatal pathway of PD animals as well as the dynamics of dopamine transmission in PD animals. Fixed speed treadmill training 30 minutes per day could ameliorate spatial-temporal gait impairment, improve walking speed, dopamine transmission as well as corticostriatal synaptic plasticity in the unilateral 6-OHDA lesioned rat model.

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Section: Discussionsupporting

confidence: 91%

Exercise Ameliorates Motor Deficits and Improves Dopaminergic Functions in the Rat Hemi-Parkinson’s Model

Chen

Kuo

Kao

et al. 2018

Sci Rep

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show abstract

“…As regards gait kinematics, the significant decrease in the GPS value (7.57° at the follow-up vs. 8.34° of baseline) indicates that after the training the kinematics of the gait pattern appeared closer to the physiological condition. As previously mentioned, there are indeed few studies that have investigated the effects of rehabilitative treatments on gait kinematics in individuals with PD ( 52 – 54 ) and none of them employ RAS as a tool to support gait training; thus, it is difficult to find data for comparisons. Moreover, the only two existing attempts to characterize the effects of RAS on kinematic patterns ( 30 , 31 ) involved diseases different from PD (i.e., stroke and cerebral palsy).…”

Section: Discussionmentioning

confidence: 99%

Effects of Physical Rehabilitation Integrated with Rhythmic Auditory Stimulation on Spatio-Temporal and Kinematic Parameters of Gait in Parkinson’s Disease

et al. 2016

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Movement rehabilitation by means of physical therapy represents an essential tool in the management of gait disturbances induced by Parkinson’s disease (PD). In this context, the use of rhythmic auditory stimulation (RAS) has been proven useful in improving several spatio-temporal parameters, but concerning its effect on gait patterns, scarce information is available from a kinematic viewpoint. In this study, we used three-dimensional gait analysis based on optoelectronic stereophotogrammetry to investigate the effects of 5 weeks of supervised rehabilitation, which included gait training integrated with RAS on 26 individuals affected by PD (age 70.4 ± 11.1, Hoehn and Yahr 1–3). Gait kinematics was assessed before and at the end of the rehabilitation period and after a 3-month follow-up, using concise measures (Gait Profile Score and Gait Variable Score, GPS and GVS, respectively), which are able to describe the deviation from a physiologic gait pattern. The results confirm the effectiveness of gait training assisted by RAS in increasing speed and stride length, in regularizing cadence and correctly reweighting swing/stance phase duration. Moreover, an overall improvement of gait quality was observed, as demonstrated by the significant reduction of the GPS value, which was created mainly through significant decreases in the GVS score associated with the hip flexion–extension movement. Future research should focus on investigating kinematic details to better understand the mechanisms underlying gait disturbances in people with PD and the effects of RAS, with the aim of finding new or improving current rehabilitative treatments.

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“…To date, kinematic data coming from three-dimensional GA have proved to be very useful not only to basically characterize the distinctive features of gait patterns in PD, but also to objectively and quantitatively assess the effects of neurosurgery, electrical stimulation, pharmacological and rehabilitative treatments [11,[81][82][83][84][85][86][87][88][89][90][91].…”

Section: Gait Kinematics In Individuals With Pdmentioning

confidence: 99%

Rhythmic Auditory Stimulation (RAS) and Motor Rehabilitation in Parkinson’s Disease: New Frontiers in Assessment and Intervention Protocols

Murgia¹,

Corona²,

Pili³

et al. 2015

TOPSYJ

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Previous studies have demonstrated that physical therapy accompanied by Rhythmic Auditory Stimulation (RAS) can improve the motor skills of patients with Parkinson’s disease and, in particular, their gait disturbances. In the present work we describe the neurological bases and perceptual-motor deficits generally associated with Parkinson’s disease, with a specific focus on gait disturbances. Within this framework, we review the role of auditory cueing in the modulation of patients’ gait, addressing this issue from the cognitive, neurological and biomechanical perspectives. In particular, we focus on the new frontiers of both assessment and intervention. With regards to the assessment, we describe the advantages of the three-dimensional quantitative multifactorial gait analysis. As concerns the intervention, we illustrate the potential impact of the administration of ecological footstep sounds as rhythmic cues.

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Effects of two different exercise programs on gait parameters in individuals with Parkinson's disease: A pilot study

Cited by 32 publications

References 12 publications

Exercise Ameliorates Motor Deficits and Improves Dopaminergic Functions in the Rat Hemi-Parkinson’s Model

Exercise Ameliorates Motor Deficits and Improves Dopaminergic Functions in the Rat Hemi-Parkinson’s Model

Effects of Physical Rehabilitation Integrated with Rhythmic Auditory Stimulation on Spatio-Temporal and Kinematic Parameters of Gait in Parkinson’s Disease

Rhythmic Auditory Stimulation (RAS) and Motor Rehabilitation in Parkinson’s Disease: New Frontiers in Assessment and Intervention Protocols

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