Effects of two frequencies of vibration on the maxillary canine distalization rate and <scp>RANKL</scp> and <scp>OPG</scp> secretion: A randomized controlled trial

Siriphan, Natchanon; Leethanakul, Chidchanok; Thongudomporn, Udom

doi:10.1111/ocr.12301

Cited by 12 publications

(19 citation statements)

References 21 publications

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“…1 Several studies have reported vibration effectively accelerates the rate of tooth movement, 1,2 though conflicting results have also been reported. 3,4 Moreover, the mechanisms that surrounding cells response to vibration were still unknown. Therefore, it is of interest to examine the mechanisms that the cells respond to vibration during the mimicking of orthodontic force application in vitro.…”

Section: Introductionmentioning

confidence: 99%

Low magnitude high frequency vibration induces RANKL via cyclooxygenase pathway in human periodontal ligament cells in vitro

Benjakul

Leethanakul

Jitpukdeebodintra

2019

Journal of Oral Biology and Craniofacial Research

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This study aimed to examine the effects of PGE2 on RANKL expression in response to vibration and vibration in combination with compressive stress and characterise this transduction pathway in periodontal ligament (PDL) cells. Methods: Cultured human PDL cells obtained from extracted premolar teeth (from six individuals) were subjected to three cycles of vibration (0.3 g, 30 Hz for 20 min every 24 h; V), compressive stress (1.5 g/cm 2 , 48 h; C) or vibration in combination with compressive stress (VC). To investigate whether the expression of RANKL and PGE2 was COX-dependent, PDL cells were treated with indomethacin prior to the onset of mechanical stimulation. RANKL and OPG expressions were examined by quantitative real-time polymerase chain reaction (qPCR). Quantification of PGE2, soluble RANKL (sRANKL) and OPG productions were measured using enzyme-linked immunosorbent assay (ELISAs). Results: All mechanical stresses (V, C and VC) significantly increased PGE2 and RANKL. OPG was not affected by vibration, but was downregulated in compressed cells (C and VC). Indomethacin abolished induction of RANKL and downregulated OPG in response to all mechanical stresses. Conclusion: These results suggest that vibration, compressive stress and vibration in combination with compressive stress induce RANKL expression in human PDL cells by activating the cyclooxygenase pathway.

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Section: Introductionmentioning

confidence: 99%

Low magnitude high frequency vibration induces RANKL via cyclooxygenase pathway in human periodontal ligament cells in vitro

Benjakul

Leethanakul

Jitpukdeebodintra

2019

Journal of Oral Biology and Craniofacial Research

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“…In vitro studies [27][28][29][30][31] and different in vivo studies [32][33][34][35][36][37] ) conducted in the past using various biomarkers and vibration devices have reported mixed results.…”

Section: Discussionmentioning

confidence: 99%

“…In a study by Ahmed 35 effect of vibrating devices was analyzed on osteocalcin. Siriphan et al 36 conducted an RCT to determine the effects of vibratory stimulus on secretion of RANKL and OPG.…”

Section: Continued)mentioning

confidence: 99%

“…Siriphan et al 36 conducted an RCT to determine the effects of vibratory stimulus on canine distalization as well as on RANKL and OPG secretion. Sixty patients with mean age of 18 to 25 years and with first premolar extracted were randomly allocated into 3 groups: 30 Hz with canine distalization group, 60 Hz with canine distalization group and canine distalization group (control).…”

Section: Summary Of Evidencementioning

confidence: 99%

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Impact of Vibration on the Levels of Biomarkers: A Systematic Review

Agrawal

2021

J Indian Orthod Soc

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Introduction: The objective of this systematic review is to assess the effect of vibrational force on biomarkers for orthodontic tooth movement. Methods: An electronic search was conducted for relevant studies (up to December 31, 2020) on the following databases: Pubmed, Google scholar, Web of Science, Cochrane Library, Wiley Library, and ProQuest Dissertation Abstracts and Thesis database. Hand searching of selected orthodontic journals was also undertaken. The selected studies were assessed for the risk of bias in Cochrane collaboration risk of bias tool. The “traffic plot” and “weighted plot” risk of bias distribution are designed in the RoB 2 tool. The 2 authors extracted the data and analyzed it. Results: Six studies fulfilled the inclusion criteria. The risks of biases were high for 4, low and some concern for other 2 studies. The biomarkers, medium, device, frequency and duration of device, as well as other data were extracted. The outcomes of the studies were found to be heterogenous. Conclusion: One study showed highly statistically significant levels of IL-1 beta with <.001. Rate of tooth movement was correlated with levels of released biomarkers under the influence of vibrational force in 3 studies, but it was found to be significant only in 1 study. It was further observed that vibration does not have any significant reduction in pain and discomfort.

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“…It was shown that there is no advantage neither in the time nor in reducing pain from using vibrational devices during orthodontic treatment 55 as well as in the retraction of canines and the level of RANKL and OPG 56 .…”

Section: ) Alveolar Microperforationsmentioning

confidence: 99%

Procedures to accelerate orthodontic treatment: Review of techniques and biological bases

Preto¹,

Rossi²,

Rossi³

et al. 2019

Int J Dentistry Res.

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To study the most common means to accelerate orthodontic treatment it was done a search in Pubmed, LILACs and Bireme databases with the uniterms: corrective orthodontics, inflammatory mediators, tooth movement, lymphokines and a manual search at Scholar Google with the terms: corticotomy, periodontal accelerated osteogenic orthodontics, piezocison, piezopuncture and alveolar microperforations. All the techniques are based on the variation of chemical mediators that stimulate colonies of ostoclasts and osteoblasts that take place in the bone metabolism. It was shown that surgical maneuvers are the most common procedures, following by phyiscal estimuli and there is great diversity between the techniques and evaluation methods so we have to do a narrative review based on chronologic appearance in literature. It was concluded that of the procedures to accelerate dental movement in orthodontic treatment, corticotomy, alveolar microperforations and accelerated periodontal osteogenic orthodontics are those that appear to be more indicated in clinical applications when considered the benefits over conventional treatment, although research with larger groups and controlled conditions is necessary to fully validate these techniques.

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Effects of two frequencies of vibration on the maxillary canine distalization rate and RANKL and OPG secretion: A randomized controlled trial

Cited by 12 publications

References 21 publications

Low magnitude high frequency vibration induces RANKL via cyclooxygenase pathway in human periodontal ligament cells in vitro

Low magnitude high frequency vibration induces RANKL via cyclooxygenase pathway in human periodontal ligament cells in vitro

Impact of Vibration on the Levels of Biomarkers: A Systematic Review

Procedures to accelerate orthodontic treatment: Review of techniques and biological bases

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