Effects of Ultraviolet Radiation on Antigenicity of Horse Serum Albumin: Formation of New Determinants

Abstract

Summary Structural alterations in horse serum albumin caused by ultraviolet radiation resulted in disappearance of the original determinants and in formation of new determinants. There was, however, enough similarity between the original and the new determinants for antibodies produced by the new determinants to show a weak affinity to the non‐irradiated albumin. Only weak antisera were produced by injecting rabbits with extensively irradiated albumin.