Effects of Ultraviolet-Ray Irradiation on Clotting Mechanism of Plasma

Kaplan, Sherman R.

doi:10.1001/jama.1951.03670200021007

Cited by 5 publications

(1 citation statement)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Irradiation of red blood cells may reduce cell activity, possibly due to haemoglobin denaturation under the irradiation. According to the literature 24 , ultraviolet-ray irradiation of fresh plasma does not alter its clotting mechanism for the blood clotting factors (prothrombin, factor V and factor VII). Therefore, the possible mechanism is membrane aggregation of red blood cells or platelets.…”

Section: Resultsmentioning

confidence: 99%

Minimally Invasive Hemostatic Materials: Tackling a Dilemma of Fluidity and Adhesion by Photopolymerization in situ

Zhang

Song

Huang

et al. 2017

Sci Rep

View full text Add to dashboard Cite

Hemostasis in vivo is a key to success in minimally invasive surgery (MIS). However, solid hemostatic materials cannot pass through the sheath tube of the MIS apparatus, while liquid ones are restricted by their low adhesion, which leads to them peeling off of tissue. To tackle the dilemma of fluidity and adhesion, a formulation containing a multifunctional sucrose allyl ether (SAE) monomer and an alpha-hydroxyketone liquid photoinitiator (HMPP) was applied as a lead hemostatic material for MIS. Real-time infrared results showed that SAE initiated by HMPP can rapidly polymerize into a transparent crosslinking membrane. Quantum chemistry showed that this occurs via a free radical addition reaction mechanism. Thermodynamic properties, such as reaction driving force and enthalpy change, were similar to those for a corresponding small molecular analogue, allyl methyl ether (AME), but the addition rate was lower than that for AME. The CC50 values of SAE and HMPP were also obtained by cell experiments. A hemostasis experiment in vivo was performed by comparing the formulation with chitosan and a traditional Chinese medicine (Yunnan Baiyao powder). The result showed that the formulation had a competitive advantage for use in MIS.

show abstract

Section: Resultsmentioning

confidence: 99%