Effects of Ureaplasma urealyticum infection on semen quality and sperm morphology

Xianchun, Fu; Fang, Jun; Dai, Zhijun; Mingyun, Hong

doi:10.3389/fendo.2023.1113130

Cited by 9 publications

(2 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Firstly, Zinzendorf et al in a study reported the effect of U. urealyticum infection on semen analyzing parameters in male patients with infertility [11] and compared it with data from normal patients. Other studies are consistent with this, researchers have shown that U. urealyticum infection in the male genital tract negatively affects semen quality [12] significantly involving the pH value, liquefaction time, concentration, and motility in semen samples. Most studies examined the role of UU in male infertility while little evidence about the mechanisms of male infertility induced by UP infections has been reported [13][14][15].…”

Section: Introductionsupporting

confidence: 74%

Normospermic Patients Infected With Ureaplasma parvum: Role of Dysregulated miR-122-5p, miR-34c-5, and miR-141-3p

Galdiero,

Trotta,

Schettino

et al. 2024

PAI

View full text Add to dashboard Cite

Background: Ureaplasma parvum (UP) is a causative agent of non-gonococcal urethritis, involved in the pathogenesis of prostatitis and epididymitis, and it could impair human fertility. Although UP infection is a frequent cause of male infertility the study evidence assessing their prevalence and the association in patients with infertility is still scarce. The molecular processes leading to defects in spermatozoa quality are not completely investigated. MicroRNAs (miRNAs) have been extensively reported as gene regulatory molecules on post-transcriptional levels involved in various biological processes such as gametogenesis, embryogenesis, and the quality of sperm, oocyte, and embryos. Methods: Therefore, the study design was to demonstrate that miRNAs in body fluids like sperm could be utilized as non-invasive diagnostic biomarkers for pathological and physiological conditions such as infertility. A post-hoc bioinformatics analysis was carried out to predict the pathways modulated by the miRNAs dysregulated in the differently motile spermatozoa. Results: Here it is shown that normospermic patients infected by UP had spermatozoa with increased quantity of superoxide anions, reduced expression of miR-122-5p, miR-34c-5, and increased miR-141-3p compared with non-infected normospermic patients. This corresponded to a reduction of sperm motility in normospermic infected patients compared with normospermic non-infected ones. A target gene prediction presumed that an essential role of these miRNAs resided in the regulation of lipid kinase activity, accounting for the changes in the constitution of spermatozoa membrane lipids caused by UP. Conclusions: Altogether, the data underline the influence of UP on epigenetic mechanisms regulating spermatozoa motility.

show abstract

Section: Introductionsupporting

confidence: 74%

Normospermic Patients Infected With Ureaplasma parvum: Role of Dysregulated miR-122-5p, miR-34c-5, and miR-141-3p

Galdiero,

Trotta,

Schettino

et al. 2024

PAI

View full text Add to dashboard Cite

show abstract

“…Mehta et al found that the rate of teratozoospermia was found to be significantly higher in men with S. faecalis compared to semen that contained micrococci, alpha - hemolytic streptococci or those that did not contain bacteria at all ( 62 ). Sperm samples with Ureaplasma urealityicum also showed a lower normal-shaped sperm than those without any ( 63 ). An in vitro study of semen contaminated with Ureaplasma urealityicum found that colonies of bacteria were attached to the head and mid-piece of sperm with abnormal morphology ( 64 ).…”

Section: Evidence Synthesismentioning

confidence: 91%

Isolated teratozoospermia: revisiting its relevance in male infertility: a narrative review

Atmoko,

Savira,

Shah

et al. 2024

Transl Androl Urol

View full text Add to dashboard Cite

Background and Objective Basic semen analysis is the first step in the evaluation of male infertility. It includes an assessment of sperm morphology which is believed to reflect on overall spermatogenesis and sperm function. Teratozoospermia, defined as abnormal sperm morphology, is frequently present in association with severe oligoasthenozoospermia, but isolated teratozoospermia (in the presence of normal counts and motility) is a poorly understood clinical entity with conflicting implications in terms of fertility potential and treatment strategies. The following paper aims to: (I) discuss the classification of sperm morphology, causes, and molecular mechanism of teratozoospermia; (II) analyze the clinical significance and potential treatment options of isolated teratozoospermia as a cause of male infertility and a predictor of fertility outcome; and (III) provide a SWOT (strengths, weaknesses, opportunities, and threats) analysis based on the existing literature on this topic. Methods A comprehensive search from database inception to 25 April 2023 was conducted in PubMed for relevant papers relating to isolated teratozoospermia in male infertility. Finally, seven systematic reviews/reviews/meta-analyses and 81 original articles were synthesized into the current narrative review. Key Content and Findings Classification of sperm morphology has evolved significantly since the first edition of the World Health Organization (WHO) Manual of Human Semen Analysis. Kruger’s strict criteria are the most used classification and have been shown to correlate with fertility outcomes. There are many causes of teratozoospermia including genetic and environmental factors and physical conditions like varicocele. Teratozoospermia correlates with sperm DNA damage, elevated oxidative stress, low antioxidant function, and apoptotic alterations, which can result in impaired spermatozoa function and lower pregnancy rates. However, the clinical correlation between teratozoospermia and assisted reproductive technology (ART) outcome shows conflicting data with recent meta-analyses suggesting that isolated teratozoospermia was not associated with poor fertility outcomes from ART and that intrauterine insemination (IUI) can be an effective option even in the presence of teratozoospermia. There is very limited data on effective therapeutic options to treat idiopathic isolated teratozoospermia. The opportunity for future research is huge to fill the gap in the medical literature on this topic. Conclusions Contemporary literature on isolated teratozoospermia shows conflicting results in terms of its actual clinical implication in male infertility and the utility of available treatment options. Further research is warranted on this clinical entity to improve sperm function and future paternity.

show abstract

Dendrobium officinale polysaccharides improved reproductive oxidative stress injury in male mice treated with cyclophosphamide

Mu,

Che,

Tang

et al. 2023

Environ Sci Pollut Res

View full text Add to dashboard Cite

Effects of Ureaplasma urealyticum infection on semen quality and sperm morphology

Cited by 9 publications

References 32 publications

Normospermic Patients Infected With Ureaplasma parvum: Role of Dysregulated miR-122-5p, miR-34c-5, and miR-141-3p

Normospermic Patients Infected With Ureaplasma parvum: Role of Dysregulated miR-122-5p, miR-34c-5, and miR-141-3p

Isolated teratozoospermia: revisiting its relevance in male infertility: a narrative review

Dendrobium officinale polysaccharides improved reproductive oxidative stress injury in male mice treated with cyclophosphamide

Contact Info

Product

Resources

About