Effects of ursolic acid on different steps of the angiogenic process

Aloe arborescens and American cranberry ( Vaccinium macrocarpon ) extracts inhibit tumor-induced cutaneous angiogenesis in mice

“…The cranberry extract inhibited transcription of MCP-1, factor produced by macrophages, which stimulates angiogenesis. In mice with melanoma, ursolic acid reduced the levels of VEGF, nitric oxide and proinflammatory cytokines and increased the levels of tissue inhibitor of metalloproteinase (TIMP1) and interleukin 2 (IL-2) in serum [19][20][21][22][23][24][25][45][46][47].…”

“…Ability of anthocyanins, proanthocyanidins, quercetin and triterpene acids to inhibit angiogenesis as well as tumor progression and metastasis was reported [19][20][21][22][23][24][25].…”

Morphometric abnormalities in spleen and kidney of the progeny of mice fed American cranberry extract (Vaccinium macrocarpon) during pregnancy and lactation

“…The large group of anticancer properties of cranberries is connected with antiangiogenic activity. Research has repeatedly proven that anthocyanins, proanthocyanidins, ursolic acid, quercetin and triterpene acids have antiangiogenic activity, and inhibit tumor progression and metastasis (Bagchi et al 2004, Cardenas et al 2004, Donnini et al 2006). Cranberries may be expected to inhibit carcinogenesis and tumor angiogenesis in part by influencing the expression of matrix metalloproteinases (MMPs).…”

Ethanol Extract of Sambucus formosana Stimulates HUVEC Proliferation and Tube Formation through MEK1/2, ERK1/2 Pathway

“…Radix Astragali, Radix Rehmanniae and Angelica sinensis have been combined used and shown to stimulate angiogenesis in some studies also [9,10]; but the mechanism underlying its angiogenic activity remains unclear. Other phytochemicals such as ursolic acid [11], flavonoids [12], ferulic acis [13] and asiaticoside [14] are suggested with angiogenesis effect to promote wound healing in previous studies. All these plant derived stimulators are known to have proangiogenic activies which will benefit human health.…”