Effects of UV Induced-Photoaging on the Hair Follicle Cycle of C57BL6/J Mice

Xu, Zeng‐Guang; Gong, Meihua; Peng, Yixuan; Yang, Daping

doi:10.2147/ccid.s310487

Cited by 15 publications

(15 citation statements)

References 36 publications

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“…Earlier, similar results have been reported on exposure of depilated C57BL/6 to UVA exposure. 53 Also, statistically significant difference ( p < 0.01) was observed between NC vs. V groups with respect to mean number of hair follicles/2400 μm (for each skin sample, hair follicle/2400 μm at five random places in the sample was tabulated) (Fig. 4A4).…”

Section: 7mentioning

confidence: 89%

Multispectroscopic, virtual and in vivo insights into the photoaging defense mediated by the natural food colorant bixin

Kapoor

Kumar

et al. 2023

Food Funct.

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Section: 7mentioning

confidence: 89%

Multispectroscopic, virtual and in vivo insights into the photoaging defense mediated by the natural food colorant bixin

Kapoor

Kumar

et al. 2023

Food Funct.

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“…It is well established that HFs provide an immune‐privileged environment, which is an important factor for maintaining host immune cells in the skin 53 . This process is also considered crucial for maintaining the bulge in HFs, where epithelial HF stem cells reside 54,55 . Similarly, HF‐maintained immune privilege is also important to suppressing immune‐mediated inflammation 56 .…”

Section: Discussionmentioning

confidence: 99%

“…53 This process is also considered crucial for maintaining the bulge in HFs, where epithelial HF stem cells reside. 54,55 Simi-larly, HF-maintained immune privilege is also important to suppressing immune-mediated inflammation. 56 Therefore, here, we first defined the pathogenesis of arsenicals in shaved haired Ptch1 +/-/C57BL/6 mice.…”

Section: Discussionmentioning

confidence: 99%

Role of hair follicles in the pathogenesis of arsenical‐induced cutaneous damage

Srivastavá

Wang

Khan

et al. 2022

Annals of the New York Academy of Sciences

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Arsenical vesicants cause skin inflammation, blistering, and pain. The lack of appropriate animal models causes difficulty in defining their molecular pathogenesis. Here, Ptch1 +/-/C57BL/6 mice were employed to investigate the pathobiology of the arsenicals lewisite and phenylarsine oxide (PAO). Following lewisite or PAO challenge (24 h), the skin of animals becomes grayish-white, thick, leathery, and wrinkled with increased bi-fold thickness, Draize score, and necrotic patches. In histopathology, infiltrating leukocytes (macrophages and neutrophils), epidermal-dermal separation, edema, apoptotic cells, and disruption of tight and adherens junction proteins can be visualized. PCR arrays and nanoString analyses showed significant increases in cytokines/chemokines and other proinflammatory mediators. As hair follicles (HFs), which provide an immune-privileged environment, may affect immune cell trafficking and consequent inflammatory responses, we compared the pathogenesis of these chemicals in this model to that in Ptch1 +/-/SKH-1 hairless mice. Ptch1 +/-/ SKH-1 mice have rudimentary, whereas Ptch1 +/-/C57BL/6 mice have well-developed HFs. Although no significant differences were observed in qualitative inflammatory responses between the two strains, levels of cytokines/chemokines differed. Importantly, the mechanism of inflammation was identical; both reactive oxygen species induction and consequent activation of unfolded protein response signaling were similar. These data reveal that the acute molecular pathogenesis of arsenicals in these two murine models is similar.

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“…UV irradiation is the dominant factor in extrinsic aging and can result in hyperpigmentation, wrinkled skin, increased roughness, and loss of elasticity [ 3 ]. Previous studies indicated that chronic exposure to UVB radiation could induce skin damage by increasing the levels of reactive oxygen species (ROS) and eventually cause characteristic symptoms of skin photoaging, such as hyperplasia of sebaceous glands, deeper and wider wrinkle formation, and reduction in skin elasticity [ 4 – 7 ]. Moreover, there is clear evidence that the development of benign and malignant neoplasms is increased on photoaged skin [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Chemical Distance Measurement and System Pharmacology Approach Uncover the Novel Protective Effects of Biotransformed Ginsenoside C-Mc against UVB-Irradiated Photoaging

Liu

Hwang

et al. 2022

Oxidative Medicine and Cellular Longevity

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Long-term exposure to ultraviolet light induces photoaging and may eventually increase the risk of skin carcinogenesis. Rare minor ginsenosides isolating from traditional medicine Panax (ginseng) have shown biomedical efficacy as antioxidation and antiphotodamage agents. However, due to the difficulty of component extraction and wide variety of ginsenoside, the identification of active antiphotoaging ginsenoside remains a huge challenge. In this study, we proposed a novel in silico approach to identify potential compound against photoaging from 82 ginsenosides. Specifically, we calculated the shortest distance between unknown and known antiphotoaging ginsenoside set in the chemical space and applied chemical structure similarity assessment, drug-likeness screening, and ADMET evaluation for the candidates. We highlighted three rare minor ginsenosides (C-Mc, Mx, and F2) that possess high potential as antiphotoaging agents. Among them, C-Mc deriving from American ginseng (Panax quinquefolius L.) was validated by wet-lab experimental assays and showed significant antioxidant and cytoprotective activity against UVB-induced photodamage in human dermal fibroblasts. Furthermore, system pharmacology analysis was conducted to explore the therapeutic targets and molecular mechanisms through integrating global drug-target network, high quality photoaging-related gene profile from multiomics data, and skin tissue-specific expression protein network. In combination with in vitro assays, we found that C-Mc suppressed MMP production through regulating the MAPK/AP-1/NF-κB pathway and expedited collagen synthesis via the TGF-β/Smad pathway, as well as enhanced the expression of Nrf2/ARE to hold a balance of endogenous oxidation. Overall, this study offers an effective drug discovery framework combining in silico prediction and in vitro validation, uncovering that ginsenoside C-Mc has potential antiphotoaging properties and might be a novel natural agent for use in oral drug, skincare products, or functional food.

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Effects of UV Induced-Photoaging on the Hair Follicle Cycle of C57BL6/J Mice

Cited by 15 publications

References 36 publications

Multispectroscopic, virtual and in vivo insights into the photoaging defense mediated by the natural food colorant bixin

Multispectroscopic, virtual and in vivo insights into the photoaging defense mediated by the natural food colorant bixin

Role of hair follicles in the pathogenesis of arsenical‐induced cutaneous damage

Chemical Distance Measurement and System Pharmacology Approach Uncover the Novel Protective Effects of Biotransformed Ginsenoside C-Mc against UVB-Irradiated Photoaging

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