Effects of Vacuum-assisted Closure on Wound Microcirculation: An Experimental Study

Chen, Shao-Zong; Li, Jing; Li, Xueyong; Xu, Longshun

doi:10.1016/s1015-9584(09)60346-8

Cited by 246 publications

(188 citation statements)

References 9 publications

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“…Further, it narrowed endothelial spaces and restored the integrity of capillary basement membranes causing a decrease in the permeability of blood vessels and wound oedema by removing excessive fluid from the wound bed. 6 An increased rate of granulation tissue formation was also shown to occur with NPWT application.…”

Section: Discussionmentioning

confidence: 97%

“…[6][7][8][9][10][11][12] In an experimental study conducted on rabbits, it was found that NPWT increased the blood circulation in the wounds by increasing the capillary calibre and blood volume and by stimulating angiogenesis. Further, it narrowed endothelial spaces and restored the integrity of capillary basement membranes causing a decrease in the permeability of blood vessels and wound oedema by removing excessive fluid from the wound bed.…”

Section: Discussionmentioning

confidence: 99%

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Negative pressure wound therapy: eleven-year experience at a tertiary care hospital

et al. 2017

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Background: Management of complicated wounds is a reconstructive challenge. A reconstructive surgeon has to be ready to face new challenges every day. Negative pressure wound therapy has revolutionized the management of complex wounds. We are presenting our experience with this wound care modality in the past 11 years.Methods: It was a prospective study conducted from January 2006 to December 2016 on patients having wounds of varied etiologies, who consented to participate in this study. Custom made low cost NPWT was used till definitive wound closure.Results: A total of 568 patients consented to participate in the study during these 11 years. No major complications were seen. Most of these were males (60.73%) in their 3rd and 4th decade. Trauma was the leading cause of wounds in 38.14%, followed by diabetic foot wounds in 21.5%. Ankle and foot was the most common site of wounds (30.92%) followed by leg (24.01%). A total of 322 small, 218 medium and 97 large size dressings were used. Most of the patients improved with the NPWT. No major complications were seen.Conclusions: NPWT is safe, effective and has proved to be revolutionary in managing difficult wounds. With the use of customized low cost NPWT the benefit can be extended to underprivileged population in under developed nations too.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Negative pressure wound therapy: eleven-year experience at a tertiary care hospital

et al. 2017

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“…9,21,22,20 This is due to narrowing of endothelial spaces with restoration of integrity of capillary basement membranes and increasing number and diameter of the capillaries that are formed. 23 However, the effect of vacuum-assisted closure on reduction and prevention of infection has not been established conclusively. 20 A study undertaken by…”

Section: Discussionmentioning

confidence: 99%

Impact of negative pressure wound therapy on open diaphyseal tibial fractures: A prospective randomized trial

Virani¹,

Dahapute²,

Bava³

et al. 2016

Journal of Clinical Orthopaedics and Trauma

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“…According to the second theory, it is estimated that angiogenesis and tissue growth are stimulated and these processes give rise to cell proliferation as a result of mechanical tissue stress. The final theory is that vacuum effect removes the protease molecules which constitute an important negative factor against wound healing and bacterial load decreases following this event [12][13][14][15]. Therefore, it is intended to produce an alive wound bed which is suitable for subsequent soft tissue reconstructions.…”

Section: Discussionmentioning

confidence: 99%

Results of Vacuum Assisted Wound Closure Application

et al. 2012

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In recent past, various methods have been used for wound treatment purpose. In this study, we aimed to compare our results established from the vacuum-assisted wound closure method, which has gained popularity day by day, with the literature. A total of 48 patients, who received vacuum-assisted wound closure treatment in our clinic between 2007and 2010, were included in this study. Etiological distribution of the patients was as follows: 32 traumatic, 6 pressure sore, 9 diabetic, and 1 iliac disarticulation. All cases were evaluated in terms of age, gender, etiology, period of treatment, and size of the wound. In the patients studied, 42 were men (87.5 %) and 6 were women (12.5 %). Mean age of the patients was 39.6 years (11-61 years). All of our traumatic patients suffered from open fracture. After the vacuum-assisted wound closure application, wound size reduced by 28.8 %, while the mean area of the surface of the wound was 94.7 cm 2 (13.7-216.3 cm 2 ) on average. After the wounds became ready for surgery, 15 of them were treated with split-thickness grafting, 9 of them were treated with secondary suture, 18 of them were treated with fullthickness grafting, and 6 of them were treated with flap.

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Effects of Vacuum-assisted Closure on Wound Microcirculation: An Experimental Study

Cited by 246 publications

References 9 publications

Negative pressure wound therapy: eleven-year experience at a tertiary care hospital

Negative pressure wound therapy: eleven-year experience at a tertiary care hospital

Impact of negative pressure wound therapy on open diaphyseal tibial fractures: A prospective randomized trial

Results of Vacuum Assisted Wound Closure Application

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