Effects of Vagal-Nerve Section on the Biliary System

Rudick, J; Hutchison, John

doi:10.1016/s0140-6736(64)91330-3

Cited by 58 publications

(19 citation statements)

References 5 publications

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“…Dilatation of the gallbladder after vagotomy has been reported by several groups (Johnson and Boyden, 1952;Rudick and Hutchison, 1964). Condon et al (1975) proposed that a dilated gallbladder may play an aetiological role in post-vagotomy diarrhoea by storing excessive volumes of bile salts which swamp the reabsorptive capacity ofthe small intestine on contraction during a meal.…”

Section: Discussionmentioning

confidence: 94%

Double-Blind Trial of Cholestyramine in Post-Vagotomy Diarrhoea

1977

Inpharma

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SUMMARY The effect of cholestyramine in post-vagotomy diarrhoea has been assessed under doubleblind conditions. Cholestyramine produced a significant improvement in frequency, urgency, and consistency of stool as well as episodic diarrhoea. Faecal bile acid excretion was significantly higher in the post-vagotomy group when compared with normal controls. These findings confirm the effectiveness of cholestyramine and support the concept of a bile acid mediated aetiology in postvagotomy diarrhoea.

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Section: Discussionmentioning

confidence: 94%

Double-Blind Trial of Cholestyramine in Post-Vagotomy Diarrhoea

1977

Inpharma

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“…This concept cannot be entertained in our experiment, for the stomach was totally removed in every dog. Several authors (Rudick and Hutchison, 1964;Cox, Doherty, and Kerr, 1958) have demonstrated changes in the extrahepatic biliary apparatus following truncal vagotomy. The gall bladder volume is doubled and the rate of emptying is decreased.…”

Section: Discussionmentioning

confidence: 99%

Selective vagal effects on the intestinal phase of gastric secretion

Middleton¹,

Kelly²,

Nyhus³

et al. 1965

Gut

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“…Some authors have reported reduced gallbladder emptying after truncal vagotomy, [23][24][25][26] whereas others have found normal values. 27,28 We believe these discrepancies may arise from differences in the timing of investigation after operation and in the different methods used for estimating gallbladder function.…”

Section: Manipulation Of Gallbladder Emptyingmentioning

confidence: 99%

Regulation and responses of gallbladder muscle activity in health and disease

Johnson

2003

ann r coll surg engl

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A complex relationship links biliary symptoms with the mechanisms of gallbladder emptying and the presence of gallstones. This relationship has been investigated by clinical studies of symptoms associated with gallstones, by investigation of gallbladder emptying and cholecystokinin (CCK) release in patients with gallstones, and after cholecystectomy, or truncal vagotomy, and in the irritable bowel syndrome (IBS). Laboratory studies examined receptor density on bovine gallbladder, and contractility of human gallbladder in response to a variety of stimuli was studied in vitro . A set of six symptoms associated with the presence of gallstones was identified; IBS appeared to be present in two-fifths of patients before cholecystectomy but only one-third of these patients had persistent IBS symptoms one year after operation. Gallbladder emptying studies confirmed the poor contraction of stone-bearing gallbladders; abnormal patterns of emptying were also found in patients with IBS. Gallbladder emptying and filling appear to be largely neurally regulated. CCK receptor density was very low in gallbladder tissue, suggesting that receptors on nerve cells might mediate the action of CCK. Relaxation of gallbladder muscle was mediated by adrenergic and nitrergic nerves. The inflammatory mediator bradykinin, however, had a strong direct action on muscle cells to cause gallbladder contraction. The work reported here gives an overview of the symptoms and mechanisms of disease associated with the presence of stones in the gallbladder.

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Effects of Vagal-Nerve Section on the Biliary System

Cited by 58 publications

References 5 publications

Double-Blind Trial of Cholestyramine in Post-Vagotomy Diarrhoea

Double-Blind Trial of Cholestyramine in Post-Vagotomy Diarrhoea

Selective vagal effects on the intestinal phase of gastric secretion

Regulation and responses of gallbladder muscle activity in health and disease

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