Effects of vaginal delivery, cesarean section and exposure to labor on endothelial function of pregnant women

Kobayashi, H.; Reid, Gregory J.; Hadfield, Marie

doi:10.1016/j.thromres.2014.08.029

Cited by 4 publications

(6 citation statements)

References 18 publications

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“…These observations suggest that vaginal delivery promotes endothelial function, while cesarean delivery impairs it. 23 …”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…These observations suggest that vaginal delivery promotes endothelial function, while cesarean delivery impairs it. 23 Another parameter to be analyzed is the mean platelet volume (MPV), a factor related to cardiovascular complications, cerebrovascular disorders, and low-grade inflammatory conditions. The increase in MPV contributes to the development of arterial and venous thrombosis and to the pathogenesis of thromboembolic complications reported in patients who gave birth by cesarean section and not by vaginal delivery.…”

Section: Risk Factorsmentioning

confidence: 99%

“…Sequential mechanical compression devices, simple graduated compression socks, low molecular weight heparin (LMWH), and fractionated heparin (FH) and unfractionated heparin (UFH) demonstrated to be effective in this issue. 4,6,[10][11][12]20,21,23,[26][27][28][29] In 2011, the American College of Obstetricians and Gynecologists (ACOG) 30 published an opinion supporting the routine use of perioperative pneumatic compression devices during cesarean section. Sequential compression devices reduce the risk of VTE by increasing femoral blood flow through mechanical compression of the lower limbs, as well as by stimulating fibrinolysis through an increase in tissue plasminogen activator concentration and a decrease in inhibitor levels.…”

Section: Prophylaxis Techniquesmentioning

confidence: 99%

“…On the other hand, the Royal College of Obstetrics and Gynecology (RCOG) classifies women who underwent cesarean section in three degrees, and recommends thromboprophylaxis only for those women classified as having a medium or high risk of thrombosis. 23 According to the French College of Gynecology and Obstetrics, 20 for all cesarean sections, thromboprophylaxis by compression stockings from the day of delivery until at least 7 days is recommended, with or without the addition of LMWH, depending on the presence and type of risk (higher or lower). Considering that the thromboembolic risk during an elective cesarean section is 3 per 1,000, and that the anticoagulant treatment is indicated for any risk higher than 3%, it is important to know the multiplicative factor of the risk, that is, the odds ratio (OR), for all additional risk factors.…”

Section: Prophylaxis Techniquesmentioning

confidence: 99%

See 4 more Smart Citations

Venous Thromboembolism and Route of Delivery – Review of the Literature

Evangelista

Slompo

Timi

2018

Rev Bras Ginecol Obstet

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Venous thromboembolism events are important causes of maternal death during pregnancy and the postpartum period worldwide. A review of the literature with the objective of evaluating venous thromboembolism events in the puerperium according to the route of delivery was performed through a bibliographic survey in the Medline, LILACS and Scielo databases. We observed that patients submitted to cesarean sections present a significantly higher risk of developing venous thromboembolism when compared with those who undergo spontaneous vaginal delivery. The pathophysiological bases for this difference were explored and described in this review, as well as the indications of prophylaxis and treatment. Doctors and health professionals must be continuously vigilant regarding this condition, since it is associated with high morbidity and mortality.

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“…These observations suggest that vaginal delivery promotes endothelial function, while cesarean delivery impairs it. 23 …”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Risk Factorsmentioning

confidence: 99%

Section: Prophylaxis Techniquesmentioning

confidence: 99%

Section: Prophylaxis Techniquesmentioning

confidence: 99%

See 3 more Smart Citations

Venous Thromboembolism and Route of Delivery – Review of the Literature

Evangelista

Slompo

Timi

2018

Rev Bras Ginecol Obstet

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Childbirth, Women, and Doulas

Hunter

Hurst

2016

Understanding Doulas and Childbirth

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Effects of mode of delivery on pro-oxidant/antioxidant balance in fetal circulation

Kobayashi¹,

Iorio²,

Yoshino³

2018

The Journal of Maternal-Fetal & Neonatal Medicine

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Our statistical analyses suggest that vaginal delivery has an effect on increasing oxidative stress as a result of the stress of labor and that an elective cesarean section does not impair the mother's oxidative stress status. Furthermore, the high BAP values in all the measurements suggest that neonates just after birth have the ability to cope with oxidative stress. Rationale In many studies, the diversity of views on the influence of mode of delivery on the redox status of neonates is likely to be caused by the use of different biomarkers to measure either the oxidative stress, the antioxidant activity, or both. Furthermore, incomplete explanation for sampling cord blood in these studies, either arterial, venous blood or both, complicates matters. To solve the above, this study was designed to assess the effects of mode of delivery on both pro-oxidants, via d-ROMs, and antioxidants, via BAP, in both umbilical arterial and venous blood samples obtained just after birth. There are no existing studies of BAP in both umbilical arterial and venous blood to which we can refer. In conclusion, our study suggests that the pro-oxidant/antioxidant balance in neonates just after birth is better than may be expected when compared to the potentials of adults (including pregnant mothers) according to interpretations of BAP/d-ROMs. This can be understood that neonates may have already been endowed with the ability to cope with oxidative stress, as informed by high BAP values in both umbilical arterial and venous blood. Vaginal delivery may have an effect on increasing oxidative stress as a result of the stress of labors (as measured by d-ROMs), and an elective cesarean section, which has better BAP/d-ROMs in umbilical venous blood than that of vaginal delivery, may not impair the mother's oxidative stress status.

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Effects of vaginal delivery, cesarean section and exposure to labor on endothelial function of pregnant women

Cited by 4 publications

References 18 publications

Venous Thromboembolism and Route of Delivery – Review of the Literature

Venous Thromboembolism and Route of Delivery – Review of the Literature

Childbirth, Women, and Doulas

Effects of mode of delivery on pro-oxidant/antioxidant balance in fetal circulation

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