Effects of vagotomy on cardiovascular and heart rate variability alterations following chronic normobaric hypoxia in adult rabbits

Alcayaga, Julio; Río, Rodrigo Del; Moya, Esteban A.; Freire, Matías; Iturriaga, Rodrigo

doi:10.1186/s40659-018-0207-2

Cited by 3 publications

(2 citation statements)

References 54 publications

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“…Additionally, Watson et al (154) found that the severity of hypoxia is related to graded autonomic dysfunction. Both animal and human experiments demonstrated that the failure to restore cardiovascular adjustment capacity can be ascribed to impaired nerves and blunt responses of the autonomic system as a result of intermittent hypoxemia in OSA (155,156). A systematic review shows that either SpO2 or SaO2 used to assess arterial oxygen saturation is correlated with time-frequency HRV during hypoxia in normal people at rest (157).…”

Section: Hrv Changes Due To Hypoxiamentioning

confidence: 99%

The Different Facets of Heart Rate Variability in Obstructive Sleep Apnea

et al. 2021

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Obstructive sleep apnea (OSA), a heterogeneous and multifactorial sleep related breathing disorder with high prevalence, is a recognized risk factor for cardiovascular morbidity and mortality. Autonomic dysfunction leads to adverse cardiovascular outcomes in diverse pathways. Heart rate is a complex physiological process involving neurovisceral networks and relative regulatory mechanisms such as thermoregulation, renin-angiotensin-aldosterone mechanisms, and metabolic mechanisms. Heart rate variability (HRV) is considered as a reliable and non-invasive measure of autonomic modulation response and adaptation to endogenous and exogenous stimuli. HRV measures may add a new dimension to help understand the interplay between cardiac and nervous system involvement in OSA. The aim of this review is to introduce the various applications of HRV in different aspects of OSA to examine the impaired neuro-cardiac modulation. More specifically, the topics covered include: HRV time windows, sleep staging, arousal, sleepiness, hypoxia, mental illness, and mortality and morbidity. All of these aspects show pathways in the clinical implementation of HRV to screen, diagnose, classify, and predict patients as a reasonable and more convenient alternative to current measures.

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Section: Hrv Changes Due To Hypoxiamentioning

confidence: 99%

The Different Facets of Heart Rate Variability in Obstructive Sleep Apnea

et al. 2021

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“…As a reliable predictor of cardiac death, arrhythmias, and sudden cardiac death, HRV is obtained and analyzed in a relatively objective and accurate manner [ 9 – 13 ]. HRV is also a predictor after myocardial infarction, and reductions in SDNN parameters also indicate a poor prognosis [ 14 – 17 ]. Previous research has suggested that primary PCI (pPCI) surgery can recanalize criminal vessels and increase vagal activity while reducing sympathetic activity, thereby improving cardiac autonomic function, leading to an increase in the HRV index after treatment [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of Short-Term Heart Rate Variability in Patients with STEMI Treated by Delayed versus Immediate Stent in Primary Percutaneous Coronary Intervention: A Prospective Cohort Study

Lin

Yang

Guo

et al. 2022

Computational and Mathematical Methods in Medicine

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Objective. Patients with ST-segment elevated myocardial infarction (STEMI) have been treated with the delayed stent strategy to reduce the occurrence of postoperative no-reflow and improve the recovery of postoperative cardiac function. However, the effects of electrocardiac activity and autonomic nerve function after primary percutaneous coronary intervention (pPCI) have been rarely reported. The purpose of this study was to investigate the effects of short-term heart rate variability (HRV) in patients with STEMI treated by immediate stent (IS) and delayed stent (DS) strategy. Methods. A total of 178 patients with STEMI were divided into 124 cases (69.66%) in the IS group and 54 cases (30.34%) in the DS group from July 2019 to September 2021. The mean heart rate, premature ventricular contraction (PVC), left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVED), and HRV indexes were compared between the two groups. Results. In terms of cardiac electrical stability, the number of PVCs, the percentage of PVCs, and the number of paired PVCs in the DS group were lower than those in the IS group. In terms of HRV, high frequency (HF) and standard deviation of all NN (SDNN) intervals were higher in the patients with DS strategy than IS strategy. There were no significant differences in the LVED and LVEF between the two groups. Conclusion. Compared to the IS strategy, the DS strategy in pPCI in patients with STEMI has advantages in postoperative cardiac electrical stability and short-term cardiac autonomic nerve function, with no difference in postoperative short-term cardiac function.

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The Role of Hepatic Vagal Tone in Ozone-Induced Metabolic Dysfunction in the Liver

Colonna

Henriquez

House

et al. 2021

Toxicological Sciences

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Air pollution has been associated with metabolic diseases and hepatic steatosis-like changes. We have shown that ozone alters liver gene expression for metabolic processes through neuroendocrine activation. This study aimed to further characterize ozone-induced changes and to determine the impact of hepatic vagotomy (HV) which reduces parasympathetic influence. Twelve-week-old male Wistar-Kyoto rats underwent HV or sham surgery five-six days prior to air or ozone exposure (0 or 1 ppm; 4 h/d for one or two days). Ozone-induced lung injury, hyperglycemia, glucose intolerance, and increases in circulating cholesterol, triglycerides, and leptin were similar in rats with HV and sham surgery. However, decreases in circulating insulin and increased HDL and LDL were observed only in ozone-exposed HV rats. Ozone exposure resulted in changed liver gene expression in both sham and HV rats (sham>HV), however, HV did not change expression in air-exposed rats. Upstream target analysis revealed that ozone-induced transcriptomic changes were similar to responses induced by glucocorticoid-mediated processes in both sham and HV rats. The directionality of ozone-induced changes reflecting cellular response to stress, metabolic pathways, and immune surveillance was similar in sham and HV rats. However, pathways regulating cell-cycle, regeneration, proliferation, cell growth, and survival were enriched by ozone in a directionally-opposing manner between sham and HV rats. In conclusion, parasympathetic innervation modulated ozone-induced liver transcriptional responses for cell growth and regeneration without affecting stress-mediated metabolic changes. Thus, impaired neuroendocrine axes and parasympathetic innervation could collectively contribute to adverse effects of air pollutants on the liver.

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Effects of vagotomy on cardiovascular and heart rate variability alterations following chronic normobaric hypoxia in adult rabbits

Cited by 3 publications

References 54 publications

The Different Facets of Heart Rate Variability in Obstructive Sleep Apnea

The Different Facets of Heart Rate Variability in Obstructive Sleep Apnea

Impact of Short-Term Heart Rate Variability in Patients with STEMI Treated by Delayed versus Immediate Stent in Primary Percutaneous Coronary Intervention: A Prospective Cohort Study

The Role of Hepatic Vagal Tone in Ozone-Induced Metabolic Dysfunction in the Liver

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