Effects of valproate on brain volumes in pediatric bipolar disorder: A preliminary study

Cazala, Fadwa; Suchting, Robert; Zeni, Cristian Patrick; Bauer, Isabelle E.; Mwangi, Benson; Wu, Mon Ju; Passos, Ives Cavalcante; Spiker, Danielle; Zunta-Soares, Giovanna; Soares, Jair C.

doi:10.1016/j.pscychresns.2018.05.006

Cited by 8 publications

(2 citation statements)

References 26 publications

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“…In the present study, we considered a PP ≥ 75% that an effect of treatment exists worthy of further investigation; disparate researchers can and should consider their own subjective probability threshold that an effect exists. We chose this value for its (a) consistency with previous work using these data (Ahn et al, 2018), (b) similarity to thresholds researchers chose in other recent trials investigating treatment effects (Bauer et al, 2018; Cazala et al, 2018; Schmitz et al, 2017), and (c) correspondence with the scientific and clinical opinion of the present research team that the current research would be worthy of further investigation if there was at least a 3 in 4 chance that the alternative hypothesis was correct. For further justification of the use of Bayesian inference in the present study (including a brief discussion of frequentist vs. Bayesian inference), see a previous inspection of these data regarding the effects of tDCS on experimental pain measures (Ahn et al, 2018).…”

Section: Methodsmentioning

confidence: 93%

The Effect of Transcranial Direct Current Stimulation on Inflammation in Older Adults With Knee Osteoarthritis: A Bayesian Residual Change Analysis

Suchting

Colpo

Rocha

et al. 2019

Biological Research For Nursing

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Transcranial direct current stimulation (tDCS) has demonstrated effectiveness in reducing clinical and experimental measures of pain in patients with chronic pain; however, research examining the mechanisms of action for the effects of tDCS has been lacking. The present study investigated the effect of active tDCS on measures of inflammation and stress. Older adults (aged 50–70 years) with knee osteoarthritis (OA) were randomly assigned to receive daily 20-min sessions of either tDCS ( n = 20) or sham tDCS ( n = 20) for 5 consecutive days. Participants provided blood samples at baseline and the end of treatment. The following measures of immune function and stress were collected: interleukin (IL)-6 and 10, tumor necrosis factor-α (TNF-α), C-reactive protein, cortisol, and β-endorphin. Generalized linear modeling evaluated each posttreatment measure as a function of tDCS group, controlling for baseline (measuring residual change, analogous to analysis of covariance). Bayesian statistical inference was used to directly quantify the probability of the effect of active tDCS. IL-6, IL-10, TNF-α, and β-endorphin demonstrated lower levels of stress and inflammation in the active tDCS group. These findings provide preliminary evidence that active (relative to sham) tDCS is associated with reduced levels of inflammation.

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Section: Methodsmentioning

confidence: 93%

The Effect of Transcranial Direct Current Stimulation on Inflammation in Older Adults With Knee Osteoarthritis: A Bayesian Residual Change Analysis

Suchting

Colpo

Rocha

et al. 2019

Biological Research For Nursing

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“…Outside the cerebellum, most studies of the effect of ASMs on neuroimaging focus on differences observed on functional MRI [117]. One study demonstrated decreased amygdalar volume in adolescents with bipolar disorder and a 6-week exposure to valproate [118].…”

Section: Discussionmentioning

confidence: 99%

A minority of patients with functional seizures have abnormalities on neuroimaging

Kerr

Lee

Karimi

et al. 2021

Journal of the Neurological Sciences

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Neuroanatomic and Functional Neuroimaging Findings

Diaz

Bauer

Sanches

et al. 2020

Bipolar Disorder: From Neuroscience to Treatment

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Effects of valproate on brain volumes in pediatric bipolar disorder: A preliminary study

Cited by 8 publications

References 26 publications

The Effect of Transcranial Direct Current Stimulation on Inflammation in Older Adults With Knee Osteoarthritis: A Bayesian Residual Change Analysis

The Effect of Transcranial Direct Current Stimulation on Inflammation in Older Adults With Knee Osteoarthritis: A Bayesian Residual Change Analysis

A minority of patients with functional seizures have abnormalities on neuroimaging

Neuroanatomic and Functional Neuroimaging Findings

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