Effects of valproate or lamotrigine monotherapy on the reproductive endocrine and insulin-related metabolic profile in Chinese adults with epilepsy: A prospective randomized study

Kwan, Patrick; Yip, Fung Ping; Hui, Andrew; Leung, Howan; Ng, Ping Wing; Hui, Kwok Fai; Chan, Iris Hiu-Shuen; Chan, Michael Ho Ming; Lam, Christopher W.K.

doi:10.1016/j.yebeh.2009.01.010

Cited by 16 publications

(9 citation statements)

References 29 publications

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“…Like in the study of Stephen et al [47] we found no effect of VPA on the LH/FSH ratio. On the other hand, Røste et al [42] reported higher LH levels in VPA treated patients than in the control group and some authors reported lower FSH levels in VPA treated patients than in controls [42,[44][45][46].…”

Section: Gonadotropinsmentioning

confidence: 99%

“…Changes in SHBG, total and free testosterone, dihydrotestosterone and androstenedione appear to be independent of the epileptic syndrome type [56]. VPA belongs to the group of enzyme non-inducing drugs and the data in the literature shows that VPA therapy does not significantly influence testosterone levels in men [38,[42][43][44][45][46][47]51] and has no effect on SHBG levels [38,44,46,47,51].…”

Section: Testosterone 5˛-dihydrotestosterone 5˛/ˇ-androstane-3˛/ˇ-dmentioning

confidence: 99%

“…Although, some studies reported no effect of VPA on FSH levels [38,43], most studies found lower FSH levels in VPA treated patients than in controls [42,46] or even suppression of FSH by VPA therapy [44,45]. In addition, no effect of VPA on the LH/FSH ratio was reported by Stephen et al [47].…”

Section: Introductionmentioning

confidence: 99%

“…Concerning the effects of valproate (VPA) on the levels of steroids and related substances, except Røste et al [42], who found higher LH levels in VPA treated male patients than in the control group, most authors did not find an effect of VPA on the LH levels [38,[43][44][45].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effects of valproate and carbamazepine monotherapy on neuroactive steroids, their precursors and metabolites in adult men with epilepsy

Hill

Zárubová

Marusič

et al. 2010

The Journal of Steroid Biochemistry and Molecular Biology

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Section: Gonadotropinsmentioning

confidence: 99%

Section: Testosterone 5˛-dihydrotestosterone 5˛/ˇ-androstane-3˛/ˇ-dmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of valproate and carbamazepine monotherapy on neuroactive steroids, their precursors and metabolites in adult men with epilepsy

Hill

Zárubová

Marusič

et al. 2010

The Journal of Steroid Biochemistry and Molecular Biology

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“…To find the answer, we must consider lots of factors, for example, neuropsychiatric, socioeconomic, genetic risks, and pregnancy,[5354555657] which may interfere with our results. In addition, simultaneous study of other factors, for example, depression, nutrition in epileptic patients could help to find a true prevalence of this side effect.…”

Section: Discussionmentioning

confidence: 99%

The Investigation of Insulin Resistance in Two Groups of Epileptic Patients Treated with Sodium Valproate and Carbamazepine

et al. 2017

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Background:Valproic acid (VPA) is a widely used broad-spectrum antiepileptic drug for therapy of generalized and focal epilepsies. Cross-sectional studies have suggested that valproate treatment may be associated with hyperinsulinemia. We decided to investigate hyperinsulinemia as a health-threatening side effect of VPA in Iranian epileptic patients.Materials and Methods:Body mass index (BMI), lipid profile, fasting serum insulin, fasting blood glucose (FBS), and homeostatic model assessment-insulin resistance (HOMA-IR) were measured in 30 VPA-treated epileptic patients and 30 controls (CBZ-treated). The Chi-square test, t-test, and Pearson correlation test were used.Results:BMI was higher in VPA group than in control group (25.7 ± 3.5 > 21.7 ± 4.1) (0.000 < 0.05). Prevalence of obesity was 16.6% in VPA group that was almost the same and even lower than general Iranian population. Serum triglyceride (TG) (150 ± 77.2) was higher than CBZ group (114 ± 35.2) (P = 0.023 < 0.05). However, serum high-density lipoprotein level was lower in VPA group than controls (45.2 ± 11.7 < 54.4 ± 13.9) (P = 0.008 < 0.05). Serum insulin, FBS, HOMA-IR, cholesterol, and low-density lipoprotein did not demonstrate statistically significant differences between the two groups (P > 0.05).Conclusion:Despite the majority of previous studies that are against VPA and according to our study, VPA could be prescribed safely and it may not cause IR and its complications.

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Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data

Nevitt

Sudell

Weston

et al. 2017

Cochrane Database of Systematic Reviews

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Overall, the high-quality evidence provided by this review supports current guidance (e.g. NICE) that carbamazepine and lamotrigine are suitable first-line treatments for individuals with partial onset seizures and also demonstrates that levetiracetam may be a suitable alternative. High-quality evidence from this review also supports the use of sodium valproate as the first-line treatment for individuals with generalised tonic-clonic seizures (with or without other generalised seizure types) and also demonstrates that lamotrigine and levetiracetam would be suitable alternatives to either of these first-line treatments, particularly for those of childbearing potential, for whom sodium valproate may not be an appropriate treatment option due to teratogenicity.

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Effects of valproate or lamotrigine monotherapy on the reproductive endocrine and insulin-related metabolic profile in Chinese adults with epilepsy: A prospective randomized study

Cited by 16 publications

References 29 publications

Effects of valproate and carbamazepine monotherapy on neuroactive steroids, their precursors and metabolites in adult men with epilepsy

Effects of valproate and carbamazepine monotherapy on neuroactive steroids, their precursors and metabolites in adult men with epilepsy

The Investigation of Insulin Resistance in Two Groups of Epileptic Patients Treated with Sodium Valproate and Carbamazepine

Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data

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