DOI: 10.58837/chula.the.2020.34
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Effects of valproic acid on fatty acid production in microorganisms and bioactive compounds from feroniella lucida (scheff.) Swingle and termite-associated fungus ISFB10

Abstract: Valproic acid or valproate (VPA) is a drug for the treatment of epilepsy, bipolar disorder, migraine headaches and neuropathic pain. Unfortunately, VPA has many side effects. In this work, it was found that productions of some fatty acids were significantly affected by VPA at the concentration of 100 μM. Further exploration of VPA on fatty acid production in microorganisms including fungi, yeast, and bacteria, as well as representative gut microbiome. This work showed that VPA could enhance, reduce or complete… Show more

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