The aim of this study is to examine the unsteady hydromagnetic flow of non-Newtonian nanofluid past a stretching sheet in the presence of variable magnetic field and chemical reaction. The system of non-linear partial differential equations governing the flow was solved using finite difference numerical approximation method. The resulting numerical schemes were simulated in MATLAB software. Furthermore, the skin-friction coefficient, Sherwood number, and Nusselt number have been presented in tabular form and discussed. The findings demonstrated that increasing Reynolds number increases velocity profiles while increasing permeability parameter, suction parameter and angle of inclination for the applied magnetic field reduces the velocity profiles of the fluid flow. Temperature of the fluid increases as the angle of inclination, magnetic number, Reynolds number and Eckert number increase but decreases as Prandtl number increases. Induced magnetic field profiles decrease as magnetic Prandtl number and suction parameter increase. Concentration profiles decrease as the chemical reaction parameter and Schmidt number increase but increase as the Soret number increases. The study is significant because fluid flow and heat transfer mechanisms with the variable magnetic considerations play an important role in magnetohydrodynamic generator or dynamo and magnetohydrodynamic pumps, nuclear reactors, vehicle thermal control, heat exchangers, cancer therapy, wound treatment and hyperthermia.