Effects of Various Concentrations of Quail Egg Solution on Glycemia and Antioxidant Parameters of Alloxan-induced Diabetic Rats

Emeka, Patrick; Igwebuike, Domnic Chibuike; Onah, Jonas Anayo

doi:10.9734/jamps/2016/22723

Cited by 7 publications

(6 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Whole eggs have predominantly been criticized for their associated risk of developing chronic diseases [ 24 ], yet the benefits of WE consumption have also been reported [ 13 ]. For instance, several groups have suggested that WE provide antioxidant properties [ 13 , 25 ], either through antioxidant peptides in the egg yolk [ 11 ] or other reactive oxygen species-reducing nutrients [ 26 ]. Other studies examining the role of quail egg consumption in rat models of T2DM have demonstrated upregulation of glutathione metabolism in alloxan-induced T2DM in Wistar rats [ 25 ] and improved oxidative stress profiles in streptozotocin-injected rats [ 27 ].…”

Section: Resultsmentioning

confidence: 99%

“…For instance, several groups have suggested that WE provide antioxidant properties [ 13 , 25 ], either through antioxidant peptides in the egg yolk [ 11 ] or other reactive oxygen species-reducing nutrients [ 26 ]. Other studies examining the role of quail egg consumption in rat models of T2DM have demonstrated upregulation of glutathione metabolism in alloxan-induced T2DM in Wistar rats [ 25 ] and improved oxidative stress profiles in streptozotocin-injected rats [ 27 ]. Raza and colleagues [ 27 ] identified that in diabetic rat liver glutathione content and glutathione S-transferase (GST) activity were decreased 65% while also observing that brain glutathione and GST activity were increased two-fold as a result of a T2DM phenotype.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Whole egg consumption increases gene expression within the glutathione pathway in the liver of Zucker Diabetic Fatty rats

et al. 2020

View full text Add to dashboard Cite

Nutrigenomic evidence supports the idea that Type 2 Diabetes Mellitus (T2DM) arises due to the interactions between the transcriptome, individual genetic profiles, lifestyle, and diet. Since eggs are a nutrient dense food containing bioactive ingredients that modify gene expression, our goal was to examine the role of whole egg consumption on the transcriptome during T2DM. We analyzed whether whole egg consumption in Zucker Diabetic Fatty (ZDF) rats alters microRNA and mRNA expression across the adipose, liver, kidney, and prefrontal cortex tissue. Male ZDF (fa/fa) rats ( n = 12) and their lean controls (fa/+) ( n = 12) were obtained at 6 wk of age. Rats had ad libitum access to water and were randomly assigned to a modified semi-purified AIN93G casein-based diet or a whole egg-based diet, both providing 20% protein (w/w). TotalRNA libraries were prepared using QuantSeq 3' mRNA-Seq and Lexogen smallRNA library prep kits and were further sequenced on an Illumina HighSeq3000. Differential gene expression was conducted using DESeq2 in R and Benjamini-Hochberg adjusted P -values controlling for false discovery rate at 5%. We identified 9 microRNAs and 583 genes that were differentially expressed in response to 8 wk of consuming whole egg-based diets. Kyto Encyclopedia of Genes and Genomes/Gene ontology pathway analyses demonstrated that 12 genes in the glutathione metabolism pathway were upregulated in the liver and kidney of ZDF rats fed whole egg. Whole egg consumption primarily altered glutathione pathways such as conjugation, methylation, glucuronidation, and detoxification of reactive oxygen species. These pathways are often negatively affected during T2DM, therefore this data provides unique insight into the nutrigenomic response of dietary whole egg consumption during the progression of T2DM.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Whole egg consumption increases gene expression within the glutathione pathway in the liver of Zucker Diabetic Fatty rats

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Antioxidants are known to mop up free radicals (Aba et al, 2015). It is also possible that the extract may have stimulated the regeneration of the islet cells.…”

Section: Resultsmentioning

confidence: 99%

Ameliorative Effects of <i>Cussonia arborea</i> Methanol Root Bark Extract on Histomorphology of Pancreas of Alloxan-Induced Diabetic Rats

Patrick

Asuzu

2016

Not Sci Biol

View full text Add to dashboard Cite

Diabetes mellitus is an endocrine and a metabolic disease resulting from the destruction of pancreatic beta cells; thus assessment of the pancreas in diabetic rats is important in monitoring therapy. The hereby study assessed pancreatic status of diabetic rats treated with methanol root bark extract of Cussonia arborea. A total of seventy two (72) male albino wistar rats weighting between 100-105 g were assigned into six (6) groups of twelve (12) rats per group. Groups 1-5 were diabetic infected by single intraperitoneal injection with alloxan monohydrate, at the dose of 160 mg/kg and treated with 62.5, 125, 250 mg/kg bw of the extract, 2 mg/kg bw glibenclamide and 10 ml/kg distilled water (DW) respectively, while the non diabetic rats, represented by Group 6, received 10 ml/kg DW and served as normal control rats. The treatment was applied daily through the oral route for 84 days. At the end of the experiment, the pancreas organs were acquired under light ether anaesthesia for histomorphometric assessment. The results indicated that the cells of the islet of langerhans of the diabetic untreated rats (Group 5) were severely depleted when compared to that of the normal rats (Group 6). The islet cells of the diabetic rats treated with 125 mg/kg Cussonia arborea extract (Group 2) was comparable to that of the diabetic rats treated with glibenclamide (Group 4) and the normal control rats. It was concluded that the methanol extract of C. arborea, especially at the dose of 125 mg/kg, ameliorated pancreatic lesions induced by diabetes occasioned by alloxan.

show abstract

“…Research done by Teușan et al (2008) stated that organic quail egg consumption has synergic effect with bioactive compound such as curcumin in order to treat prediabetic condition. Aba et al (2015) also stated that egg from a quail that is fed with organic feed contains important nutrition such as amino acids (leucine, valine, and alanine), vitamin E and mineral such as zinc.…”

Section: Research Conducted Bymentioning

confidence: 99%

Histopathology of Pre-diabetic White Rat (Rattus norvegicus L.) Renal After Treatment with Turmeric Powder and Organic Quail Eggs

LAZUARDI

SUPRIHATIN²,

TANA³

2022

BJRST

View full text Add to dashboard Cite

Pre-diabetic is a disease that is caused by insulin resistance, which is identified by higher blood glucose levels than normal. Turmeric (Curcuma longa L.) contains curcumin compounds that act as antioxidants to prevent damage from free radicals and to repair damaged kidney tissue from pre-diabetic condition. Organic quail eggs are supplements that can help to repair kidney tissue. This study investigated the effect of turmeric powder and organic quail eggs on pre-diabetic kidney tissue histopathology of male white rats. Twenty-five male white rats (Rattus norvegicus L.) were used in this study and they were divided into 5 treatment groups, namely D0 (normal white rats were given standard diet), D1 (positive control, pre-diabetic white rats were given standard diet), D2 (pre-diabetic white rats were given turmeric powder 1.35 mg/head/day), D3 (pre-diabetic white rats were given 1 organic quail egg/head/day), and D4 (pre-diabetic white rats were given turmeric powder 1.35 mg/head/day and 1 organic quail egg/head/day). This research was done within 60 days. The results of the study were analysed using the ANOVA and Duncan tests. The analysis results showed that turmeric powder and organic quail eggs treatments had a significant effect on the observed parameters. The conclusion of this study is that the effect of turmeric powder and organic quail eggs has the potential to repair the kidney tissue of pre-diabetic white rats

show abstract

Effects of Various Concentrations of Quail Egg Solution on Glycemia and Antioxidant Parameters of Alloxan-induced Diabetic Rats

Cited by 7 publications

References 7 publications

Whole egg consumption increases gene expression within the glutathione pathway in the liver of Zucker Diabetic Fatty rats

Whole egg consumption increases gene expression within the glutathione pathway in the liver of Zucker Diabetic Fatty rats

Ameliorative Effects of <i>Cussonia arborea</i> Methanol Root Bark Extract on Histomorphology of Pancreas of Alloxan-Induced Diabetic Rats

Histopathology of Pre-diabetic White Rat (Rattus norvegicus L.) Renal After Treatment with Turmeric Powder and Organic Quail Eggs

Contact Info

Product

Resources

About