Effects of various levels of dietary Artemisia abyssinica leaves on rats

Adam, Safwaan; Al‐Qarawi, A. A.; Elhag, E. A.

doi:10.1258/002367700780384744

Cited by 16 publications

(15 citation statements)

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“…As the liver is the organ that protects the individual against toxic injury, it seems that the dose of F. vulgare given to mice in this study exceeded the capacity of the liver to repair the damage. Many authors reported that toxic plants have induced similar liver damage in different animal species [25] [26] [27] [28]. The results of the present study have also revealed that F. vulgare induced toxic damage in kidney tissues.…”

Section: Discussionsupporting

confidence: 79%

Toxico-Pathological Studies of Foeniculum vulgare Plant in Mice

Al-Hizab¹,

Hussein²,

Hasseeb³

et al. 2018

OJPathology

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Background and objective: Foeniculum vulgare-Mill (Umlliferae), is widely used in the Arabian Peninsula for treating various human and animal diseases. There is need to insure the safety of this plant as a remedy that could be used for a long time. This study aimed to determine the LD 50 of the aerial parts of Foeniculum vulgare in mice, as well as to investigate its toxic pathological effects. Methodology: A total of eighty (80) albino mice of both sexes, weighing 25 -30 g, were used in the present study. Ten (10) mice were used for the determination of LD 50 of Foeniculum vulgare in mice. Fifty (50) mice were used in the acute toxicity, and twenty (20) mice were used to study the subacute toxicity of the aerial parts of Foeniculum vulgare juice. Results: the present results revealed that the LD 50 of Foeniculum vulgare juice in mice was 9.772 mg/kg/body weight (BW). On the other hand, mice received 0.9 mg/kg/BW of Foeniculum vulgare juice intraperitoneally showed slightly closed eyes intermittent convulsions itching of the nose and increased respiratory rate and abdominal movements. Histopathological examination of the liver showed hepatocytic degeneration and necrosis, congestion with perivascular mononuclear cell infiltrations and peribiliary mononuclear cell aggregations. Whereas the spleen of mice showed depletion of lymphocytes and mononuclear as well as multinuclear cells. The duodenum showed sub-epithelial congested blood vessels, numerous areas of lymphocytic infiltrations and vascular and hydropic degeneration of epithelial cells lining the duodenal Brunner's glands. Moreover, the kidney showed degenerated tubular epithelial cells, congestion with excess of mononuclear cells, necrotic and desquamated epithelial cells of the proximal convoluted tubules. The lung of mice showed congestion, emphysema with variable degrees of mononuclear cell infiltrations and peribronchial congested blood capillaries and mononuclear cell infiltration. Conclusion: It could be concluded that Foeniculum vulgare juice is toxic to mice when administered in a dose of 9.772 mg/kg/BW. How- (1/10 of the LD 50 ) of Foeniculum vulgare juice.

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Section: Discussionsupporting

confidence: 79%

Toxico-Pathological Studies of Foeniculum vulgare Plant in Mice

Al-Hizab¹,

Hussein²,

Hasseeb³

et al. 2018

OJPathology

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“…The essential oil of A. absinthium originating from different countries has been the subject of previous investigations and different chemotypes were reported in literature [3][4][5][6][7][8]12]. Four chemotypes were identified to be characteristic of A. absinthium grown in Europe: sabinene and myrcene rich oil, α-and β-thujone rich oil, epoxyocimene rich oil, and (E)-sabinyl acetate rich oil.…”

Section: Resultsmentioning

confidence: 99%

“…Bip., A. herba-alba Asso., A. judaica L. and A. monosperma Del. are used in folk medicine as anthelmintics, antispasmodics, antirheumatics and antibacterial agents due to the presence of alkaloids, flavonoids, sterols, tannins, volatile oils and anthraquinones [7].…”

Section: Introductionmentioning

confidence: 99%

Essential oil composition of four Artemisia species from Ethiopia

Asfaw¹,

Demissew²

2015

Bull. Chem. Soc. Eth.

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ABSTRACT. The essential oil composition of four Artemisia species, namely A. schimperi Sch. Bip. ex Engl. A. abyssinica Sch. Bip. ex A. Rich., A. afra Jacq. ex Willd., and A. absinthium L. (previously called A. rehan) from Ethiopia has been studied. The essential oil obtained from A. absinthium (seedling from Europe) grown in two places in Ethiopia (Addis Ababa and Butajira) was also analyzed for comparison. Morphological study on the leaves of A. absinthium L. from Ethiopia (previously called A. rehan) and A. absinthium (from Europe) was also conducted. The essential oils were obtained by hydrodistillation using a Clevenger apparatus and analyzed by capillary GC and GC/MS. Forty three compounds representing 76 to 94% of the oils were identified. The composition of the essential oils of A. schimperi, A. afra and A. abyssinica are mainly dominated by irregular monoterpenes: yogomi alcohol (13.5-37.6%), artemisyl acetate (12.7-35.5%), and artemisia ketone (2.3-13.2%). The composition of the oil of A. absinthium (previously A. rehan) however, differs from the other three species in having camphor (21.2-28.3%) and davanone (21.3-26.5%) as major components. The composition of A. absinthum (Europe) was found to have β-thujone (42.3-66.4%) and chamazulene (11.3-24.2%) as major components. The study indicated that the composition of the essential oil of A. absinthium (previously A. rehan) is not only different from the other three species but also from A. absinthium from Europe and does not belong to any of the chemotypes described for the species in the literature. The morphological study on the leaves also showed that it differs from that of A. absinthium from Europe.

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“…This is due to induction of CYP450 enzyme. Adam et al (2000) ▶, also reported the presence of alkaloids, flavonoids, sterols, tannins, volatile oils and anthraquinones in aerial parts of the Artemisia species. These compounds were considered according to findings of Iriadam et al (2006) ▶ for detoxification of organs.…”

Section: Introductionmentioning

confidence: 98%

The Antioxidant Effects of Artemisia deserti Ethanolic Extract and Diazinon on Male Rat Kidney

Noori

Amjad

Yazdani

2016

Zahedan J Res Med Sci

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Background: Artemisia is a diverse genus of Asteraceae family that has pharmacological effects such as antiinflammatory, anticancer, antidiabetic and is used for treatment of diseases, including antioxidant effects against oxidative stress. Objectives: This study investigated the antioxidant effects of Artemisia deserti Krasch extract and diazinon. Materials and Methods: In this experimental study, Artemisia deserti was collected from Isfahan, Iran then 20 g of flower powder was extracted with 150 mL 80% ethanol and the 100, 200 mg/kg concentrations of ethanolic extract were prepared. The 48 male rats were divided in to 6 groups include the 1. Control, 2. diazinon treated group, 3. Diazinon + extract (100 mg/kg), 4. Diazinon + extract (200 mg/kg), 5 and 6. extract treated groups (100 and 200 mg/kg) respectively. The blood samples were collected and the rate of urea, uric acid, creatinine, serum total antioxidant and MDA (malondialdehyde) were assayed in serum. Also, the kidney tissue was isolated for histopathological examination. Finally, the statistical comparisons were done with one-way ANOVA test. Results: The rate of creatinine and MDA were changed significantly in the group that had received the extract (200 mg/kg) alone. Moreover, results indicate tissue disorders in all groups compared to controls, including the degeneration of proximal and distal tubules, atrophied glomeruli and accumulation of inflammatory cells. These abnormalities were associated with oxidative stress in some groups. Conclusions: Diazinon cause oxidative stress and kidney disorders, similar to the effect of artemisinin on kidney; therefore, simultaneous use of these compounds could enhance the toxic effects.

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Effects of various levels of dietary Artemisia abyssinica leaves on rats

Cited by 16 publications

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Toxico-Pathological Studies of <i>Foeniculum vulgare</i> Plant in Mice

Toxico-Pathological Studies of <i>Foeniculum vulgare</i> Plant in Mice

Essential oil composition of four Artemisia species from Ethiopia

The Antioxidant Effects of Artemisia deserti Ethanolic Extract and Diazinon on Male Rat Kidney

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Effects of various levels of dietary Artemisia abyssinica leaves on rats

Cited by 16 publications

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Toxico-Pathological Studies of &lt;i&gt;Foeniculum vulgare&lt;/i&gt; Plant in Mice

Toxico-Pathological Studies of &lt;i&gt;Foeniculum vulgare&lt;/i&gt; Plant in Mice

Essential oil composition of four Artemisia species from Ethiopia

The Antioxidant Effects of Artemisia deserti Ethanolic Extract and Diazinon on Male Rat Kidney

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Toxico-Pathological Studies of <i>Foeniculum vulgare</i> Plant in Mice

Toxico-Pathological Studies of <i>Foeniculum vulgare</i> Plant in Mice