Effects of various thiols on paraquat toxicity

Szabó, L.; Matkovics, B.; Barabás, Katalin; Oroszlán, G

doi:10.1016/0742-8413(86)90028-9

Cited by 8 publications

(3 citation statements)

References 19 publications

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“…In a previous study [36], GSH and its oxidized form (GSSG), L-cysteine and L-cystine failed to inhibit the induction of sister chromatid exchanges in cultured hamster cells exposed to nitrogen oxides. On the other hand, Lcystine has been demonstrated to protect mice against the toxicity induced by paraquat, a pesticide exerting genotoxic effects in various organs due to production of reactive oxygen species (ROS) [18,19]. CS produces large amounts of ROS [37] and generates an increased burden of peroxynitrite, which causes apoptosis [38].…”

Section: Discussionmentioning

confidence: 99%

“…The two agents were incorporated in the food by means of a mixer (Blender HB4, Hobart, Troy, OH, USA), adjusting their concentrations as related to the body weight of animals and to the daily food consumption, in order to obtain a ''calculated daily intake''. The highest doses tested were chosen after a review of the literature [18][19][20][21][22], taking into account toxicity data regarding the two drugs and their safe doses recommended for use in humans.…”

Section: Chemicalsmentioning

confidence: 99%

See 1 more Smart Citation

Chemoprevention of smoke-induced alopecia in mice by oral administration of l-cystine and vitamin B6

D’Agostini

Fiallo

Pennisi

et al. 2007

Journal of Dermatological Science

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Section: Discussionmentioning

confidence: 99%

Section: Chemicalsmentioning

confidence: 99%

Chemoprevention of smoke-induced alopecia in mice by oral administration of l-cystine and vitamin B6

D’Agostini

Fiallo

Pennisi

et al. 2007

Journal of Dermatological Science

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“…The administration of vitamin E has protective effects, and its deficiency potentiates paraquat-induced lung injury and fibrosis in animals (18,187). Thiol-based antioxidants also have protective effects in the paraquat model, including GSH (79,192), NAC (83,216,223), and erdosteine (92). In addition, the polyphenolic compound curcumin has been reported to have protective properties against paraquat-induced lung injury (206).…”

Section: Fibrogenic Drugs Antioxidants and Oxidative Stressmentioning

confidence: 99%

Antioxidants as Potential Therapeutics for Lung Fibrosis

Day

2008

Antioxidants & Redox Signaling

126

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Interstitial lung disease encompasses a large group of chronic lung disorders associated with excessive tissue remodeling, scarring, and fibrosis. The evidence of a redox imbalance in lung fibrosis is substantial, and the rationale for testing antioxidants as potential new therapeutics for lung fibrosis is appealing. Current animal models of lung fibrosis have clear involvement of ROS in their pathogenesis. New classes of antioxidant agents divided into catalytic antioxidant mimetics and antioxidant scavengers are being developed. The catalytic antioxidant class is based on endogenous antioxidant enzymes and includes the manganese-containing macrocyclics, porphyrins, salens, and the non-metal-containing nitroxides. The antioxidant scavenging class is based on endogenous antioxidant molecules and includes the vitamin E analogues, thiols, lazaroids, and polyphenolic agents. Numerous studies have shown oxidative stress to be associated with many interstitial lung diseases and that these agents are effective in attenuating fibroproliferative responses in the lung of animals and humans.

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Chemoprevention of doxorubicin-induced alopecia in mice by dietary administration of l-cystine and vitamin B6

et al. 2012

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Chemotherapy-induced hair loss is one of the most serious and feared adverse effects of cancer therapy. Almost all traditional chemotherapeutic agents induce a more or less severe alopecia. At present, there is no effective treatment capable of preventing this damage. Several different experimental approaches, using various animal models, have been investigated over the last years, with promising results. Sulphur-containing amino acids (cystine, cysteine) are essential components for the health of normal hair. L-Cystine is used in the treatment of various forms of alopecia. Vitamin B6 plays an important role in the development and maintenance of the skin and it is useful in reducing hair loss. In the present study, we demonstrated that the combined oral administration at high dosages of L-cystine (1,600 or 800 mg/kg body weight/day) and vitamin B6 (160 or 80 mg/kg body weight/day) is an effective chemopreventive treatment against alopecia induced by doxorubicin treatment (1.1 mg/kg body weight intravenously) in C57BL/6 mice.

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Effects of various thiols on paraquat toxicity

Cited by 8 publications

References 19 publications

Chemoprevention of smoke-induced alopecia in mice by oral administration of l-cystine and vitamin B6

Chemoprevention of smoke-induced alopecia in mice by oral administration of l-cystine and vitamin B6

Antioxidants as Potential Therapeutics for Lung Fibrosis

Chemoprevention of doxorubicin-induced alopecia in mice by dietary administration of l-cystine and vitamin B6

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