Effects of various vacuum cleaners on the airborne content of major cat allergen (Fel d 1)

Blay, F. De; Spirlet, F.; Gries, P.; Casel, S.; Ott, M.; Pauli, G.

doi:10.1111/j.1398-9995.1998.tb03914.x

Cited by 21 publications

(5 citation statements)

References 9 publications

(11 reference statements)

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“…Emission rates for cat allergen were based on studies that characterized the occurrence, suspension, and removal of cat allergen, Fel d 1 , inside homes [ 7 , 42 , 43 ]. Based on findings from those studies, we chose to model generation of cat allergen with a constant and intermittent source.…”

Section: Methodsmentioning

confidence: 99%

Control of asthma triggers in indoor air with air cleaners: a modeling analysis

Myatt¹,

Minegishi²,

Allen³

et al. 2008

Environ Health

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Background: Reducing exposure to environmental agents indoors shown to increase asthma symptoms or lead to asthma exacerbations is an important component of a strategy to manage asthma for individuals. Numerous investigations have demonstrated that portable air cleaning devices can reduce concentrations of asthma triggers in indoor air; however, their benefits for breathing problems have not always been reproducible. The potential exposure benefits of whole house high efficiency in-duct air cleaners for sensitive subpopulations have yet to be evaluated.

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Section: Methodsmentioning

confidence: 99%

Control of asthma triggers in indoor air with air cleaners: a modeling analysis

Myatt¹,

Minegishi²,

Allen³

et al. 2008

Environ Health

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“…In an experimental room with cat allergen present in dust, levels of allergen in air can reach y5 ng?m -3 when the room is vacuum cleaned [33]. Since the tidal volume of breathing is y8 L?min -1 , the total volume of air being ventilated during 24 h is y10 m 3 .…”

Section: Discussionmentioning

confidence: 99%

Reduced late asthmatic response by repeated low-dose allergen exposure

et al. 2001

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Reduced late asthmatic response by repeated low-dose allergen exposure. M. Palmqvist, Z-H. Cui, M. Sjöstrand, A. Lindén, J.Lötvall. #ERS Journals Ltd 2001. ABSTRACT: Allergic asthmatic individuals are often exposed to low-doses of allergen in their everyday life. Extended exposure to allergen has lead to down-regulation of the allergic process in cell systems and in animal models. The aim of this study was to evaluate whether any such inhibitory mechanism of allergic responses can be seen in man in vivo.Patients with mild asthma were repeatedly and double-blindly exposed to 25% of the individual dose of allergen that caused an early (EAR) and late asthmatic reaction (LAR). One day after the low-dose allergen or placebo exposure periods, the same individual was given a high-dose allergen challenge. Sputum and blood were collected for the evaluation of eosinophils.Exposure to repeated low doses of allergen induced increased bronchial methacholine responsiveness 6 h after the final allergen exposure (p~0.018), and an increase in the number of eosinophils in sputum. By contrast, the late asthmatic response after challenge with a high dose of allergen was significantly attenuated by y30% at 24 h after the final low-dose allergen exposure (p~0.03).In summary, repeated low doses of allergen given directly to the airways, attenuate the high-dose allergen-induced late response, despite enhanced bronchial hyperresponsiveness to methacholine and elevated sputum eosinophils prior to allergen challenge.

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“…Moreover, in natural settings, vacuum cleaner bags may be over-full or torn, resulting in leakage of dust and mite allergens during use. Hence, caution should be exercised when recommending vacuuming as a means to control allergen load because it may inadvertently increase personal exposure to inhabitants, especially if care is not taken to ensure that vacuum cleaners with over-full or leaky dust collection bags are not used (De Blay et al, 1998). This possibility is supported by an epidemiological study on 72 homes in Tasmania, which reported that frequent vacuum cleaning of at least once a week was associated with significantly higher environmental dust-mite allergen concentrations than homes which vacuumed infrequently (Couper et al, 1998).…”

Section: Discussionmentioning

confidence: 99%