Effects of vasoactive intestinal peptide and its homologues on the substance P-mediated secretion of fluid and protein from the rat submandibular gland

Iwabuchi, Yoshiki; Masuhara, Taizo

doi:10.1016/0306-3623(94)90249-6

Cited by 12 publications

(2 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A growing list of neuropeptides has been identified that appear to play an important role in the regulation of the SMG metabolism (102). Secretin and VIP enhance norepinephrine (NE)-and substance P (SP)-mediated secretion of fluid and protein from rat SMG (103,104). Calcitonin gene-related peptide (CGRP), SP and VIP, are most likely involved in the non-adrenergic, noncholinergic (NANC) secretion of saliva in response to stimulation of parasympathetic innervation (102,105,106).…”

Section: B +C Submandibular Gland Cells (Iimentioning

confidence: 99%

Cystatin S: Molecular biology and sympathetic innervation

Shaw

Chaparro

1998

Biomedical Reviews

View full text Add to dashboard Cite

The ratsubmandibular glands (SMG) are innervated by both the sympathetic and the parasympathetic branches of the autonomic nervous system which, in turn,regulate the secretory functions of the glands. Parasympathetic innervation of rat SMG is present at birth, whereas sympathetic nerve fibers reach the glands by postnatal day 5. Isoproterenol (IPR), a fi-adrenoceptor agonist, induces hypertrophic and hyperplastic enlargements of rat salivary glands, and induces the expression of a number of genes, including cystatin S, a member of family 2 of the cysteine proteinase inhibitor superfamily. Cystatin S gene expression is tissue-and cell typespecific, occurs transiently during development, and is not observed in adult animals. Sympathetic denervation of adult SMG, achieved by removing the superior cervical ganglion, reduces the induction of the cystatin S gene by a single injection of IPR. In addition, recent data indicate that the j3receptors present early in the developing SMG are functional and are capable of responding to IPR by increasing the ex pression of the cystatin S gene, even when sympathetic nerve fibers have not reached the gland. The level of I PR-induced cystatin S mRNA remains constant until day 8, at which time a dramatic induction of cystatin S mRNA is observed. This

show abstract

Section: B +C Submandibular Gland Cells (Iimentioning

confidence: 99%

Cystatin S: Molecular biology and sympathetic innervation

Shaw

Chaparro

1998

Biomedical Reviews

View full text Add to dashboard Cite

show abstract

“…The substance P-mediated secretion of fluid from rat submandibular glands is enhanced by pretreatment with calcitonin gene-related peptide (CGRP) (Ekstrom et a1 1988), vasoactive intestinal polypeptide (VIP) (Iwabuchi & Masuhara 1994) and secretin (Iwabuchi & Masuhara 1994), all of which elevate intracellular levels of CAMP. However, the mechanism responsible for the modification of the effect of substance P by CAMP-elevating agents is unknown.…”

mentioning

confidence: 99%

Interaction Between Substance P and β-Adrenergic Agonists in the Modulation of the Secretion of Fluid and Protein by the Rat Submandibular Gland

Iwabuchi

Kimura

1998

Journal of Pharmacy and Pharmacology

Self Cite

View full text Add to dashboard Cite

The interactions between substance P and beta-adrenergic agonists such as isoprenaline, dobutamine and terbutaline in the control of the secretion of fluid and protein from the rat submandibular gland have been examined. Substance P elicited large volumes of saliva whereas isoprenaline, dobutamine and terbutaline elicited small volumes only. The secretion of fluid in response to substance P was markedly enhanced when substance P was administered in combination with isoprenaline or dobutamine but not when it was administered in combination with terbutaline. Isoprenaline elicited large amounts of protein, whereas substance P elicited small amounts. The secretion of protein in response to isoprenaline did not change when isoprenaline was administered in combination with substance P. The secretion of fluid and protein induced by substance P in combination with isoprenaline was antagonized by metoprolol and by spantide, but it was unaffected by pretreatment with ICI118551. These results suggest that in the rat submandibular gland stimulation of beta1-adrenoceptors but not of beta2-adrenoceptors potentiates the secretion of fluid that is induced by stimulation of tachykinin receptors, whereas stimulation of tachykinin receptors does not enhance the secretion of protein that is induced by stimulation of beta1-adrenoceptors.

show abstract

Effects of vasoactive intestinal peptide and its homologues on the acetylcholine-mediated secretion of fluid and protein from the rat submandibular gland

Iwabuchi

Masuhara

1995

General Pharmacology: The Vascular System

View full text Add to dashboard Cite

1. Acetylcholine-mediated (ACh-mediated) secretion of fluid and protein from rat submandibular glands was enhanced by intravenous injection of vasoactive intestinal peptide (VIP) and of secretin but not of peptide histidine isoleucine (PHI) or gastric inhibitory peptide (GIP). 2. When VIP and ACh were administered together, the enhancement of fluid secretion was inhibited by pretreatment with atropine or 4-DAMP and the enhancement of protein secretion was inhibited by pretreatment with atropine or phentolamine. 3. The enhancement of the ACh-induced secretion of fluid by secretin was strongly inhibited by pretreatment with atropine, and it was weakly inhibited by pretreatment with phentolamine or haloperidol. 4. These results suggest that the synergistic effects of VIP, PHI, secretin and GIP on the ACh-mediated secretion of fluid and protein from the rat submandibular gland do not reflect the extent of the structural homology of each peptide to VIP.

show abstract

Effects of vasoactive intestinal peptide and its homologues on the substance P-mediated secretion of fluid and protein from the rat submandibular gland

Cited by 12 publications

References 20 publications

Cystatin S: Molecular biology and sympathetic innervation

Cystatin S: Molecular biology and sympathetic innervation

Interaction Between Substance P and β-Adrenergic Agonists in the Modulation of the Secretion of Fluid and Protein by the Rat Submandibular Gland

Effects of vasoactive intestinal peptide and its homologues on the acetylcholine-mediated secretion of fluid and protein from the rat submandibular gland

Contact Info

Product

Resources

About