Effects of vector ultrasonic system debridement and
conventional instrumentation on the levels of TNF-α in gingival
crevicular fluid of patients with chronic periodontitis

Arpağ, Osman Fatih; Dağ, Ahmet; İzol, Bozan Serhat; Cimitay, Gülcan; Uysal, Ersin

doi:10.17219/acem/65410

Cited by 5 publications

(4 citation statements)

References 20 publications

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“…It is well known that the goal of typical nonsurgical periodontal treatment is to remove biofilm to create the ideal environment for efficient bacterial plaque management [5,68,69]. Historically, scaling and root planing with manual instrumentation has been the most commonly used method of root surface debridement, with both clinical and microbiological benefits [70][71][72], as demonstrated by the studies included in this review [19][20][21][22][23][24][25][26][27]. Manual instrumentation also appears to be more effective in reducing the probing depth in moderate and severe periodontal pockets, according to Zhang et al, although no particular statistically significant differences were found with ultrasonic instrumentation [64].…”

Section: Discussionmentioning

confidence: 96%

“…According to the studies included in the review [19][20][21][22][23][24][25][26][27], there was no statistically significant differences between the treatments proposed, demonstrating the achievement of clinical outcomes with the use of ultrasonic scalers and hand instruments. These results are consistent with previous research [64][65][66][67].…”

Section: Discussionmentioning

confidence: 99%

“…Table 1. RCTs included (ultrasonic and manual instruments) [19][20][21][22][23][24][25][26][27]. All treatments resulted in a significant clinical improvement, but there were no significant differences among groups.…”

Section: Rcts (Ultrasonic and Manual Instruments)mentioning

confidence: 99%

“…Table 5. Risk of bias of articles (ultrasonic and manual instruments) [19][20][21][22][23][24][25][26][27]. The table shows the risk of bias of each study included in the review (a green symbol was assigned where the information was complete and accurate; a yellow symbol was allocated where information was missing).…”

Section: Risk Of Bias Of Rcts Includedmentioning

confidence: 99%

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Effectiveness of Ultrasonic and Manual Instrumentation in Nonsurgical Periodontal Therapy: Are Additional Therapies More Effective? A Systematic Review

Sabatini,

Maiorani,

Bassignani

et al. 2024

Applied Sciences

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Nonsurgical periodontal therapy aims to remove supragingival and subgingival biofilm to restore periodontal health. This systematic review aims to assess the clinical effectiveness of manual and/or ultrasonic instruments and to determine whether other therapies can improve periodontal clinical outcomes. Case-control, cross-sectional and cohort studies and clinical trials of patients undergoing nonsurgical periodontal therapy with ultrasonic and/or manual instruments (and any adjunctive therapies, such as glycine, erythritol, ozone, laser and glycine) from 2013 to 2023 were analyzed using Pub-med/MEDLINE, Scopus and Google Scholar. To assess the risk of bias in this review, blinding, randomization, allocation concealment, outcome data and outcome recording were assessed. No differences between treatments were found; all methods, including manual and ultrasound, were helpful in improving clinical parameters (primary outcome). Although the results were mixed, adjunctive therapies seemed to be helpful in the treatment of periodontal disease. The results of this systematic review are consistent with the previous scientific literature and have shown that both manual and ultrasonic instruments are effective in nonsurgical periodontal therapy. This review could not show how complementary therapies could further improve nonsurgical periodontal therapy. For future research, it would be good to standardize the sample with regard to the degree and stage of periodontal disease and to evaluate the risks and benefits of the instruments (manual and ultrasonic scalers).

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Rcts (Ultrasonic and Manual Instruments)mentioning

confidence: 99%

Section: Risk Of Bias Of Rcts Includedmentioning

confidence: 99%

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Effectiveness of Ultrasonic and Manual Instrumentation in Nonsurgical Periodontal Therapy: Are Additional Therapies More Effective? A Systematic Review

Sabatini,

Maiorani,

Bassignani

et al. 2024

Applied Sciences

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Tumor Necrosis Factor-alpha in Gingival Crevicular Fluid as a Diagnostic Marker for Periodontal Diseases: A Systematic Review

Madureira

Lima

Costa

et al. 2018

Journal of Evidence Based Dental Practice

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Estimation of Proinflammatory Factors in the Saliva of Adult Patients with Cystic Fibrosis and Dental Caries

et al. 2020

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Introduction: The available literature lacks data regarding the levels of resistin, lysozyme, lactoferrin, α-amylase activity, pH, and saliva buffer capacity, as well as oral health and hygiene in the group of adult patients with cystic fibrosis (CF). The aim of the research was to assess the selected saliva parameters in patients diagnosed with cystic fibrosis. Materials and methods: Examined group was composed of 40 patients diagnosed with CF, while the control group of 40 healthy individuals. Both groups underwent the same scheme of the assessment (DMT index, salivary pH, buffer capacity, analysis of total sialic acid, total protein estimation, lysozyme levels estimation, lactofferin levels measurement, α-amylase activity, estimation of the levels of resistin and TNF-α). Results: In the examined group, there were higher values of decayed teeth as well as values of sialic acid, total protein, lactoferrin, α-amylase, and TNF-α. However, mean lysozyme, and resistin levels, as well as pH and buffer capacity of the saliva, were lower. Conclusions: New diagnostic methods, including the evaluation of selected salivary biochemical parameters, may indicate the existence of factors predisposing to severe tooth decay in the study group. Appropriate preventive treatment to combat dental caries in adult patients with CF will significantly improve their comfort and life expectancy.

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Effects of vector ultrasonic system debridement and conventional instrumentation on the levels of TNF-α in gingival crevicular fluid of patients with chronic periodontitis

Abstract: Background. Tumor necrosis factor alpha (TNF-α) is an inflammatory mediator whose levels are increased in the gingival crevicular fluid and blood serum in the case of chronic periodontitis.

Cited by 5 publications

References 20 publications

Effectiveness of Ultrasonic and Manual Instrumentation in Nonsurgical Periodontal Therapy: Are Additional Therapies More Effective? A Systematic Review

Effectiveness of Ultrasonic and Manual Instrumentation in Nonsurgical Periodontal Therapy: Are Additional Therapies More Effective? A Systematic Review

Tumor Necrosis Factor-alpha in Gingival Crevicular Fluid as a Diagnostic Marker for Periodontal Diseases: A Systematic Review

Estimation of Proinflammatory Factors in the Saliva of Adult Patients with Cystic Fibrosis and Dental Caries

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