Effects of Vibrissectomy during Early Postnatal Ontogenesis in Rat Pups on Behavioral Development

Shishelova, A. Yu.; Raevskii, V. V.

doi:10.1007/s11055-010-9310-8

Cited by 10 publications

(9 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…; Shishelova ; Celikel and Sakmann ; Lee et al. ; Shishelova and Raevskii ). One behavioral task that can be used to study whisker‐related behavior is the gap‐crossing test in which the mouse or rat uses its whiskers to estimate the distance to a target platform and subsequently make a jump–no jump decision over the gap separating the two platforms (Hutson and Masterton ; Harris et al.…”

Section: Introductionmentioning

confidence: 99%

“…The earlier during development sensory deprivation occurs, the more likely it is that subcortical structures and the formation of the layer 4 barrel pattern are affected, whereas plasticity later in life is predominately cortical in origin and affecting supra-and infragranular layers (Van der Loos and Woolsey 1973; Durham and Woolsey 1984;Simons and Land 1987;Armstrong-James and Callahan 1991;Fox et al 1996;Glazewski et al 1998;Wallace et al 2001). The behavioral consequence of changes to the whisker system includes defects in texture discrimination and defensive behavior (Barneoud et al 1991;Carvell and Simons 1996;Harris et al 1999;Shishelova 2006;Celikel and Sakmann 2007;Lee et al 2009;Shishelova and Raevskii 2010). One behavioral task that can be used to study whisker-related behavior is the gap-crossing test in which the mouse or rat uses its whiskers to estimate the distance to a target platform and subsequently make a jump-no jump decision over the gap separating the two platforms (Hutson and Masterton 1986;Harris et al 1999;Jenkinson and Glickstein 2000;Sachdev et al 2000;Celikel and Sakmann 2007;Voigts et al 2008).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Sensory deprivation during early development causes an increased exploratory behavior in a whisker‐dependent decision task

2012

View full text Add to dashboard Cite

Stimulation of sensory pathways is important for the normal development of cortical sensory areas, and impairments in the normal development can have long-lasting effect on animal's behavior. In particular, disturbances that occur early in development can cause permanent changes in brain structure and function. The behavioral effect of early sensory deprivation was studied in the mouse whisker system using a protocol to induce a 1-week sensory deprivation immediately after birth. Only two rows of whiskers were spared (C and D rows), and the rest were deprived, to create a situation where an unbalanced sensory input, rather than a complete loss of input, causes a reorganization of the sensory map. Sensory deprivation increased the barrel size ratio of the spared CD rows compared with the deprived AB rows; thus, the map reorganization is likely due, at least in part, to a rewiring of thalamocortical projections. The behavioral effect of such a map reorganization was investigated in the gap-crossing task, where the animals used a whisker that was spared during the sensory deprivation. Animals that had been sensory deprived performed equally well with the control animals in the gap-crossing task, but were more active in exploring the gap area and consequently made more approaches to the gap – approaches that on average were of shorter duration. A restricted sensory deprivation of only some whiskers, although it does not seem to affect the overall performance of the animals, does have an effect on their behavioral strategy on executing the gap-crossing task.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sensory deprivation during early development causes an increased exploratory behavior in a whisker‐dependent decision task

2012

View full text Add to dashboard Cite

show abstract

“…Some findings suggest that vibrissae removal in rats has long-lasting effects on the development of the cortical formations (Shishelova and Raevskii, 2010;Shishelova, Aliev, and Raevskii, 2016); these results point to the consequences and difficulties in performing spatial tasks even after the regrowth of normal vibrissae.…”

Section: Discussionmentioning

confidence: 99%

“…Overviews in the literature report various behavioral models used to investigate effects of various types of sensory deprivation on behavior during early development (Korneeva, Aleksandrov, Golubeva, and Raevskii, 2010;Shishelova, 2006;Shishelova and Raevskii, 2010;Shishelova, Aliev, and Raevskii, 2016).…”

Section: Introductionmentioning

confidence: 99%

Effects of early sensory deprivation on spatial learning in adult rats

Kurzina

Aristova

Volnova

2017

BioComm

View full text Add to dashboard Cite

Following vibrissae removal in early ontogenesis from P1 (post-natal day 1) to P30, three-month old rats were trained to run for food in an 8-arm radial maze. Training started at the age of three months. Adult rats demonstrated ability to perform the behavioral task; however, their performance was not as good as in the control group. Our findings revealed the differences in the rats` exploratory strategy and key behavioral tactics of entering the maze arms at a certain angle. The results show that active vibrissae sensing plays an important role in shaping rat behavioral tactics during spatial learning in the 8-arm radial maze.

show abstract

“…It is not only maternal care, but also by interaction with siblings and a comfortable state in nest habitat. A disturbance of the development of intact rat pups nursed together with vibrissectomized siblings testifies to this [1]. In this connection, in order to identify the significance of social factors of early ontogenesis in the development WAG/Rij rats, individual isolation of pups from the nest was performed, which deprives pup from the entire complex of species-specific sensory signals.…”

mentioning

confidence: 99%

Social Deprivation of Newborn Rats Modifies Exploratory and Defensive Behavior at Mature Age

Shishelova¹,

Smirnov²,

Raevskiy³

2019

JBBS

View full text Add to dashboard Cite

The effect of complete social deprivation in early postnatal ontogenesis on adult behavior in Wag/Rij rats with a genetic predisposition to the development of absence epilepsy was studied. From the 2 nd to the 8 th day of life, a 3-hour daily isolation of the pups from the mother and siblings was performed, the control animals were handled. In adulthood, offspring behavior was tested in an elevated plus-maze, an open field, and for an ability to learn the conditioned reflex of active avoidance. In isolated earlier rats, an increase in emotional reactivity, exploratory behavior in a potentially dangerous space, the speed of learning a conditioned reflex with negative painful reinforcement, and a disturbance of the formation of a defensive reaction were revealed. It is assumed that high emotional reactivity creates the prerequisites for the development of absence epilepsy.

show abstract

Effects of Vibrissectomy during Early Postnatal Ontogenesis in Rat Pups on Behavioral Development

Cited by 10 publications

References 20 publications

Sensory deprivation during early development causes an increased exploratory behavior in a whisker‐dependent decision task

Sensory deprivation during early development causes an increased exploratory behavior in a whisker‐dependent decision task

Effects of early sensory deprivation on spatial learning in adult rats

Social Deprivation of Newborn Rats Modifies Exploratory and Defensive Behavior at Mature Age

Contact Info

Product

Resources

About