1980
DOI: 10.1016/0304-419x(80)90021-9
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Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells

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Cited by 535 publications
(441 citation statements)
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“…All-trans retinoic acid (RA) interferes with the proliferation and differentiation of cells of various lineages [1][2][3][4]. It appears that alteration of membrane receptors for growth and differentiation factors mediates most effects of RA [5][6][7].…”
Section: Introductionmentioning
confidence: 99%
“…All-trans retinoic acid (RA) interferes with the proliferation and differentiation of cells of various lineages [1][2][3][4]. It appears that alteration of membrane receptors for growth and differentiation factors mediates most effects of RA [5][6][7].…”
Section: Introductionmentioning
confidence: 99%
“…It has been clearly established that retinoids (vitamin A and its analogues) can cause reversible loss of anchorage-independent growth (an acknowledged marker for oncogenically transformed cells) of a large number of transformed cell lines of diverse origin, as well as intervene in the process of oncogenesis in vivo (reviewed in [1,2]). However, some transformed cells do not lose their ability to form colonies in agar medium upon treatment with retinoids [1][2][3][4].…”
Section: Introductionmentioning
confidence: 99%
“…However, some transformed cells do not lose their ability to form colonies in agar medium upon treatment with retinoids [1][2][3][4]. It is not known what causes the differential response to retinoids by various transformed cells.…”
Section: Introductionmentioning
confidence: 99%
“…These include the labilization of membranes, an increase in cell adhesiveness, an increase in humoral and cell-mediated immunity, inhibition of cell growth and induction of differentiation (Lotan, 1980). The last effect has been demonstrated in nullipotent mouse embryonal carcinoma cells (Jetten & Jetten, 1979).…”
mentioning
confidence: 99%
“…Cell-culture experiments have shown growth inhibition or delay of many types of tumours from different species after addition of retinoids (Lotan, 1980). However, growth inhibition in vivo has been shown in few of the animal tumours tested (Trown et al, 1976;Kistler & Peter, 1979).…”
mentioning
confidence: 99%