Effects of vitamin A-deficiency and inflammation on the conducting airway epithelium of Syrian golden hamsters

McDowell, Elizabeth M.; DeSanti, Andrea M.; Newkirk, Carnell; Strum, Judy M.

doi:10.1007/bf02899409

Cited by 13 publications

(5 citation statements)

References 39 publications

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“…These effects can be demonstrated only experimentally. However, there are studies that show the protective effects of vitamin A supplementation via restoration of normally differentiated epithelia, providing a more effective barrier to infection 15 . Despite the lack of direct evidence of the effect of vitamin A on uroepithelial defense mechanisms, the decrease of the UTI attack rate in the present patients could be attributed to the enhancement of mucosal immunity.…”

Section: Discussionmentioning

confidence: 68%

Adjuvant effect of vitamin A on recurrent lower urinary tract infections

Yılmaz

Bahat

Yilmaz

et al. 2007

Pediatrics International

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Section: Discussionmentioning

confidence: 68%

Adjuvant effect of vitamin A on recurrent lower urinary tract infections

Yılmaz

Bahat

Yilmaz

et al. 2007

Pediatrics International

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“…It has been shown that vitamin A deficiency alone or in combination with benzo (a)-pyrene caused squamous metaplasia, a precursor of squamous cell carcinoma, in the epithelium of the trachea and stem bronchi in hamsters in vivo and in organ culture (17, 29, 30). Treatments with β-carotene, retinol or other retinoids reversed or reduced this response (30, 31).…”

Section: Discussionmentioning

confidence: 99%

β-Carotene promotes the development of NNK-induced small airway-derived lung adenocarcinoma

Al-Wadei

Schüller

2009

European Journal of Cancer

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Aim-Beta-carotene has shown cancer preventive effects in preclinical studies while increasing lung cancer mortality in clinical trials. We have shown that β-carotene stimulates cAMP signaling in vitro. Here, we have tested the hypothesis that beta-carotene promotes the development of pulmonary adenocarcinoma (PAC) in vivo via cAMP signaling. Methods: PAC was induced in hamsters with the carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) followed by β-carotene for 1.5 years. Incidence, multiplicity and size of lung tumors were recorded and phosphorylated CREB and ERK1/2 in tumour cells determined by Western blots. Cyclic AMP in blood cells was analysed by immunoassays, retinoids in serum and lungs by HPLC. Results: beta-carotene increased lung tumor multiplicity, lung tumour size, blood cell cAMP, serum and lung levels of retinoids and induced p-CREB and p-ERK1/2 in lung tumours. Conclusions:Our data suggest that beta-carotene promotes the development of PAC via increased cAMP signaling.

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“…Vitamin A increases both immune response efficacy to infection once the epithelial barrier has been disrupted [80] and non-specific immunity, by supporting the physical and biological integrity of epithelial tissue as the first barrier to infection [81]. Furthermore, it can provide a more effective barrier against infection by restoring normally differentiated epithelium that coats the urinary tract, preventing pathogen adhesion [82].…”

Section: Utimentioning

confidence: 99%

Are We Sentenced to Pharmacotherapy? Promising Role of Lycopene and Vitamin A in Benign Urologic Conditions

et al. 2022

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Benign prostatic hyperplasia, urolithiasis, recurrent urinary tract infections, and chronic prostatitis are diseases that are commonly diagnosed worldwide. Carotenoids, including lycopene, are widely available in fruits and vegetables, and it is postulated that they can be used in the prevention and treatment of benign urological conditions. The aim of this review is to familiarize doctors and their patients with the current knowledge on carotenoids and their conversion products in selected urological diseases. Most of the experimental and clinical trials show a moderate effect of lycopene and vitamin A on studied parameters. Lycopene was shown to improve the IPSS score in BPH patients, and alleviate symptoms in those with chronic prostatitis. Intake of Vitamin A was associated with decrease of urinary tract reinfection rates. In studied rat models retinol also decreased urolithiasis formation. Although the results of the cited studies are generally promising, it is evident that more detailed and extensive research must be done in this field of medicine.

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Effects of vitamin A-deficiency and inflammation on the conducting airway epithelium of Syrian golden hamsters

Cited by 13 publications

References 39 publications

Adjuvant effect of vitamin A on recurrent lower urinary tract infections

Adjuvant effect of vitamin A on recurrent lower urinary tract infections

β-Carotene promotes the development of NNK-induced small airway-derived lung adenocarcinoma

Are We Sentenced to Pharmacotherapy? Promising Role of Lycopene and Vitamin A in Benign Urologic Conditions

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