Effects of vitamin B<b><sub>12</sub></b> on bright light on cognitive and sleep–wake rhythm in Alzheimer‐type dementia

Itō, Takao; Yamadera, Hiroshi; Ito, Ritsuko; Suzuki, Hideaki; Asayama, K; Endo, Shunkichi

doi:10.1046/j.1440-1819.2001.00860.x

Cited by 33 publications

(25 citation statements)

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“…Although hallucinations are rare in patients with FTD, the significant negative correlation with serum levels of vitamin B 12 could indicate that lower levels of vitamin B 12 predispose to the development of hallucinations. The significant negative correlation between diurnal rhythm disturbances and levels of vitamin B 12 in FTD patients could be meaningful as positive effects of vitamin B 12 treatment on sleepwake rhythm in patients with sleep disorders and AD have been reported (Ito et al, 2001). As a correlation does not necessarily imply a causative relation, the pathophysiological mechanisms underlying these findings remain to be elucidated.…”

Section: Discussionmentioning

confidence: 97%

Correlations between cognitive, behavioural and psychological findings and levels of vitamin B₁₂ and folate in patients with dementia

Engelborghs

Vloeberghs

Maertens

et al. 2004

Int J Geriat Psychiatry

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The observed negative correlations between levels of vitamin B12 and folate and cognitive impairment in both AD and FTD patients, raise the possibility of a non-specific etiological role. Although levels of vitamin B12 and folate did not correlate with BPSD in AD patients, negative correlations between serum vitamin B12 levels and BPSD in FTD patients were revealed. Decreased serum vitamin B12 levels may predispose FTD patients to develop hallucinations and diurnal rhythm disturbances.

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Section: Discussionmentioning

confidence: 97%

Correlations between cognitive, behavioural and psychological findings and levels of vitamin B₁₂ and folate in patients with dementia

Engelborghs

Vloeberghs

Maertens

et al. 2004

Int J Geriat Psychiatry

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“…Accordingly, prospective studies of individuals with B12-deficient dementia show patients with delirium187 or psychoses359 improve with vitamin B12 supplementation. In demented individuals, prospective studies show vitamin B12 supplementation enhances vigilance when combined with bright light therapy,497 improves mood disturbances,475 but may worsen motor performance 353. Although not a consistent finding, 187,362 supplemental B12 in B12-deficient dementia may be beneficial for some patients with BPSD 359,475.…”

Section: Discussionmentioning

confidence: 99%

Cobalamin deficiency, hyperhomocysteinemia, and dementia

Werder¹

2010

NDT

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IntroductionAlthough consensus guidelines recommend checking serum B12 in patients with dementia, clinicians are often faced with various questions: (1) Which patients should be tested? (2) What test should be ordered? (3) How are inferences made from such testing? (4) In addition to serum B12, should other tests be ordered? (5) Is B12 deficiency compatible with dementia of the Alzheimer’s type? (6) What is to be expected from treatment? (7) How is B12 deficiency treated?MethodsOn January 31st, 2009, a Medline search was performed revealing 1,627 citations related to cobalamin deficiency, hyperhomocysteinemia, and dementia. After limiting the search terms, all abstracts and/or articles and other references were categorized into six major groups (general, biochemistry, manifestations, associations and risks, evaluation, and treatment) and then reviewed in answering the above questions.ResultsThe six major groups above are described in detail. Seventy-five key studies, series, and clinical trials were identified. Evidence-based suggestions for patient management were developed.DiscussionEvidence is convincing that hyperhomocysteinemia, with or without hypovitaminosis B12, is a risk factor for dementia. In the absence of hyperhomocysteinemia, evidence is less convincing that hypovitaminosis B12 is a risk factor for dementia. B12 deficiency manifestations are variable and include abnormal psychiatric, neurological, gastrointestinal, and hematological findings. Radiological images of individuals with hyperhomocysteinemia frequently demonstrate leukoaraiosis. Assessing serum B12 and treatment of B12 deficiency is crucial for those cases in which pernicious anemia is suspected and may be useful for mild cognitive impairment and mild to moderate dementia. The serum B12 level is the standard initial test: 200 picograms per milliliter or less is low, and 201 to 350 picograms per milliliter is borderline low. Other tests may be indicated, including plasma homocysteine, serum methylmalonic acid, antiparietal cell and anti-intrinsic factor antibodies, and serum gastrin level. In B12 deficiency dementia with versus without pernicious anemia, there appear to be different manifestations, need for further workup, and responses to treatment. Dementia of the Alzheimer’s type is a compatible diagnosis when B12 deficiency is found, unless it is caused by pernicious anemia. Patients with pernicious anemia generally respond favorably to supplemental B12 treatment, especially if pernicious anemia is diagnosed early in the course of the disease. Some patients without pernicious anemia, but with B12 deficiency and either mild cognitive impairment or mild to moderate dementia, might show some degree of cognitive improvement with supplemental B12 treatment. Evidence that supplemental B12 treatment is beneficial for patients without pernicious anemia, but with B12 deficiency and moderately-severe to severe dementia is scarce. Oral cyanocobalamin is generally favored over intramuscular cyanocobalamin.

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“…Ito et al . furthered the investigation into efficacy of bright light therapy in maintenance of circadian rhythms in their quasi‐experiment on 28 older adults with Alzheimer's disease 46 . Ito et al .…”

Section: Resultsmentioning

confidence: 99%

Effectiveness of strategies to manage sleep in residents of aged care facilities

Haesler

2004

JBI Reports

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Executive summary Background The promotion of sleep in older adults is a significant issue in high‐level residential aged care facilities, with as many as 67% of residents experiencing disruptions to their sleep patterns. Not only do health concerns such as cognitive impairment, pain and incontinence impact upon this population's sleep quality and quantity, but environmental factors including noise, light and night‐time nursing care also affect sleep of those residing in institutions. In order to address the issue of sleep disruption, assessment and diagnosis of sleep problems and implementation of interventions that are effective in promoting sleep are essential. Objectives The objective of this review was to determine the most effective tools for the assessment and diagnosis of sleep in older adults in high‐level aged care. The review also sought to determine the most effective strategies for the promotion of sleep in this population. Outcome measures for this review were: indicators of improved sleep quality and quantity, including an improvement in daytime functioning and improved night‐time sleep; reduction in use of hypnotics and sedatives; and increased satisfaction with sleep. Search strategy A literature search was performed using the following databases for the years 1993–2003: AgeLine, APAIS Health, CINAHL, Cochrane Library, Current Contents, Dissertation Abstracts International, Embase, Medline, Proquest, PsycInfo, Science Citations Index. A second search stage was conducted through review of reference lists of studies retrieved during the first search stage. The search was limited to published and unpublished material in English language. Selection criteria The review was limited to papers addressing sleep diagnosis, assessment and/or management in adults aged 65 or over who were residing in high‐level aged care. The review included randomised controlled trials (RCTs) and, due to the limited number of RCTs available, non‐RCTs, cohort and case control studies and qualitative research were also considered for inclusion. Research was included if it addressed the assessment, diagnosis or management of sleep using outcome measure of improved night‐time sleep or daytime function, improvements in resident satisfaction with sleep or reduction in medication use associated with sleep. The types of interventions considered by this review were alternative therapies including massage, aromatherapy and medicinal herbs; behavioural or cognitive interventions; biochemical interventions; environmental interventions; pharmacological interventions and related nocturnal interventions such as continence care. Instruments and strategies to diagnose and assess the sleep of older high‐level care residents, including objective and subjective assessment tools, were considered by this review. Data collection and analysis All retrieved papers were critically appraised for eligibility for inclusion and methodological quality independently by two reviewers, and the same reviewers collected details of eligible research. Paper...

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Effects of vitamin B₁₂ on bright light on cognitive and sleep–wake rhythm in Alzheimer‐type dementia

Cited by 33 publications

References 7 publications

Correlations between cognitive, behavioural and psychological findings and levels of vitamin B₁₂ and folate in patients with dementia

Correlations between cognitive, behavioural and psychological findings and levels of vitamin B₁₂ and folate in patients with dementia

Cobalamin deficiency, hyperhomocysteinemia, and dementia

Effectiveness of strategies to manage sleep in residents of aged care facilities

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Effects of vitamin B12 on bright light on cognitive and sleep–wake rhythm in Alzheimer‐type dementia

Cited by 33 publications

References 7 publications

Correlations between cognitive, behavioural and psychological findings and levels of vitamin B12 and folate in patients with dementia

Correlations between cognitive, behavioural and psychological findings and levels of vitamin B12 and folate in patients with dementia

Cobalamin deficiency, hyperhomocysteinemia, and dementia

Effectiveness of strategies to manage sleep in residents of aged care facilities

Contact Info

Product

Resources

About

Effects of vitamin B₁₂ on bright light on cognitive and sleep–wake rhythm in Alzheimer‐type dementia

Correlations between cognitive, behavioural and psychological findings and levels of vitamin B₁₂ and folate in patients with dementia

Correlations between cognitive, behavioural and psychological findings and levels of vitamin B₁₂ and folate in patients with dementia