Effects of vitamin B12 and B6 on 2,5-hexanedione-induced neuropathy

Misumi, Jyuji; Nagano, Makoto; Kaisaku, Jun; Hitoshi, Taizo

doi:10.1007/bf00333428

Cited by 7 publications

(5 citation statements)

References 11 publications

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“…Alleviation of mechanical hyperalgesia in streptozotocin-induced diabetic rats by a mixture of vitamins B1, B6 and B12, or by vitamin B6 alone was associated with improved sensory nerve conduction velocity (Jolivalt et al, 2009), but no such change was found in rats rendered diabetic with 2,5-hexanedione and treated with vitamin B6 or B12 alone (Misumi et al, 1985). Other possible antihyperalgesic mechanisms of B vitamins include inhibition of the diacylglycerol-protein kinase C (PKC) pathway (Hammes et al, 2003;Sánchez-Ramírez et al, 2006), enhanced cGMP production by guanylylcyclase enzyme (Vesely, 1985) and increased afferent inhibitory control of nociceptive neurons at the spinal cord (Fu et al, 1998).…”

Section: Discussionmentioning

confidence: 89%

B vitamins relieve neuropathic pain behaviors induced by infraorbital nerve constriction in rats

Kopruszinski

Reis

2012

Life Sciences

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Section: Discussionmentioning

confidence: 89%

B vitamins relieve neuropathic pain behaviors induced by infraorbital nerve constriction in rats

Kopruszinski

Reis

2012

Life Sciences

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“…Previously, it has been reported that single or combined administration of thiamine, pyridoxine, and cyanocobalamin is able to reduce thermal hyperalgesia, but not mechanical allodynia, in dorsal root ganglion compression and CCI models [25] . In addition, Misumi et al [26] were not able to demonstrate an antiallodynic effect of either pyridoxine or cyanocobalamin on 2,5-hexanedione-induced neuropathy in rats. Differences could be due to the different way to induce neuropathy in the rats.…”

Section: Antiallodynic Effect Of B Vitamins and Dexamethasonementioning

confidence: 99%

Thiamine and Cyanocobalamin Relieve Neuropathic Pain in Rats: Synergy with Dexamethasone

Caram-Salas¹,

Reyes-Garcı́a

Medina-Santillán

et al. 2006

Pharmacology

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Treatment of neuropathic pain is an area of largely unmet medical need. Therefore, this pain may require the development of novel drug entities. In the search for alternatives, B vitamins have been found to be a clinically useful pharmacological tool for patients with neuropathic pain. However, preclinical studies supporting this use are lacking. In this study, we assessed the possible antiallodynic effects of thiamine, pyridoxine, and cyanocobalamin as well as dexamethasone and their combination on spinal nerve ligation induced allodynia. Sub cutaneous administration of thiamine (75–600 mg/kg), pyridoxine (75–600 mg/kg), cyanocobalamin(0.75–6 mg/kg), and dexamethasone (4–32 mg/kg) significantly reduced tactile allodynia in rats. Maximal antiallodynic effects were reached with 600 mg/kg of thiamine (∼58%), 600 mg/kg of pyridoxine (∼22%), 6 mg/kg of cyanocobalamin (∼73%), and 32 mg/kg of dexamethasone (∼68%). Since a small antiallodynic effect was observed with pyridoxine, this drug was not further analyzed in the combinations. Coadministration of thiamine or cyanocobalamin and dexamethasone remarkably reduced spinal nerve ligation induced allodynia (∼90%), showing a synergistic interaction between either thiamine or cyanocobalamin and dexamethasone. Our data indicate that thiamine and pyridoxine as well as the combination of B vitamins and dexamethasone are able to reduce tactile allodynia in rats and suggest the possible clinical use of these drugs in the treatment of neuropathic pain in human beings.

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“…Various studies have reported that 2,5-HO produces sensory deficits (Abou-Donia et al, 1985;Bastone et al, 1987;DiVicenzo et al, 1976;Fedtke & Bolt, 1987;Herskowitz et al, 1971;Misumi et al, 1985). Accordingly, animals treated with high doses of 2,5-HO should have been less sensitive to footshock than the animals in the vehicle group.…”

Section: Discussionmentioning

confidence: 97%

Effects of chronic treatment with 2,5-hexanedione on several behavioral measures in rats

1992

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Exposure to hexacarbon compounds may cause several neurotoxic effects in both animals and humans. In the present study, we subcutaneously administered, chronically for 15-50 days, 2,5-HD (a toxic metabolic ofn-hexane) to invelitigate-its effects on open-field behavior, step-down inhibitory avoidance, and shuttle avoidance. The results demonstrated that at 20 mg/kg 2,5-HD did not alter any of the behavioral tasks analyzed. On the other hand, at 200 mg/kg 2,5-HD caused significant reductions on body-weight gain (10% at 25 days of treatment and 25% at 61 days) and the general motor activity of rats treated for 15 or 30 days; treatment did not interfere with habituation to the open field. Inhibitory avoidance performance was not affected, but shuttle avoidance was significantly impaired in the high-dose, long-and short-term treated rats, probably as a consequence of the general debilitation of motor activity in treated rats.Exposure to hexacarbon compounds may cause distal axonopathy in the central and peripheral nervous systems of both humans and animals (Spencer, Schaumburg, Sabri, & Veronesi, 1980). Various studies have demonstrated that workers occupationally exposed to n-hexane present peripheral polyneuropathy (Couri & Milks, 1982; Herskowitz, Ishii, & Schaumburg, 1971). n-Hexane is metabolized to a series of metabolites, including 1hexanol, 2-hexanol, 3-hexanol, 2-hexanone, 5-hydroxy-2-hexanone, and 2,5-hexanedione (Couri & Milks, 1982;DiVicenzo, Kaplan, & Dedinas, 1976). Although the exact mechanism underlying the neurotoxic effects of hexacarbon compounds is not yet established, it has been demonstrated that the hexacarbon compound 2,5-hexanedione may cause severe toxic effects with chronic administration to animals, including severe deficits in motor and sen-

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Effects of vitamin B12 and B6 on 2,5-hexanedione-induced neuropathy

Cited by 7 publications

References 11 publications

B vitamins relieve neuropathic pain behaviors induced by infraorbital nerve constriction in rats

B vitamins relieve neuropathic pain behaviors induced by infraorbital nerve constriction in rats

Thiamine and Cyanocobalamin Relieve Neuropathic Pain in Rats: Synergy with Dexamethasone

Effects of chronic treatment with 2,5-hexanedione on several behavioral measures in rats

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