Effects of vitamin C and E supplementation on oxidative stress and liver toxicity in rats fed a low-fat ethanol diet

Lee, Soo-Jung; Kim, Seon‐Young; Min, Hyesun

doi:10.4162/nrp.2013.7.2.109

Cited by 22 publications

(15 citation statements)

References 41 publications

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“…However, the effect of α-tocopherol on plasma homocysteine level was inconsistent. A recent study had also shown that α-tocopherol reduced serum homocysteine in rats fed methionine and cholesterol diet [17], but it was ineffective in rats fed a low-fat ethanol diet [20]. The ineffective effect of α- tocopherol on hyperhomocysteinaemia was also reported in humans [26,35].…”

Section: Discussionmentioning

confidence: 97%

Palm tocotrienol-rich fraction inhibits methionine-induced cystathionine β-synthase in rat liver

et al. 2015

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Oxidative stress plays an important role in cardiovascular diseases. The study investigated the effects of dietary palm tocotrienol-rich fraction on homocysteine metabolism in rats fed a high-methionine diet. Forty-two male Wistar rats were randomly assigned to six groups. Five groups were fed with high-methionine diet (1%) for 10 weeks. Groups 2 to 5 were also given dietary folate (8 mg/kg) and three doses of palm tocotrienol-rich fraction (30, 60 and 150 mg/kg) from week 6 to week 10. The last group was only given basal rat chow. High-methionine diet increased plasma homocysteine after 10 weeks, which was prevented by the supplementations of folate and high-dose palm tocotrienol-rich fraction. Hepatic S-adenosyl methionine (SAM) content was unaffected in all groups but S-adenosyl homocysteine (SAH) content was reduced in the folate group. Folate supplementation increased the SAM/SAH ratio, while in the palm tocotrienol-rich fraction groups, the ratio was lower compared with the folate. Augmented activity of hepatic cystathionine β-synthase and lipid peroxidation content by high-methionine diet was inhibited by palm tocotrienol-rich fraction supplementations (moderate and high doses), but not by folate. The supplemented groups had lower hepatic lipid peroxidation than the high-methionine diet. In conclusion, palm tocotrienol-rich fraction reduced high-methionine-induced hyperhomocysteinaemia possibly by reducing hepatic oxidative stress in high-methionine-fed rats. It may also exert a direct inhibitory effect on hepatic cystathionine β-synthase.

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Section: Discussionmentioning

confidence: 97%

Palm tocotrienol-rich fraction inhibits methionine-induced cystathionine β-synthase in rat liver

et al. 2015

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“…Experimental treatment with ethanol diet induces oxidative stress and consequent liver toxicity, independent of the levels of fat in diet, and that tocopherol supplementation has a protective effect against oxidative stress and liver toxicity in rats [20]. Shirpoor et al [21] demonstrated that treatment with vitamin E induces a significant amelioration of brain atrophy and DNA damage in the offspring of female Wistar rats that received ethanol during gestation and seven days of lactation.…”

Section: Discussionmentioning

confidence: 99%

Oxidative Damage in Rats Receiving Ethanol and Supplemented with Vitamin E

Jordão¹,

Monteiro²,

Santos³

et al. 2017

AJBLS

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Abstract:The metabolism of ethanol is directly related to oxidative stress, and its ingestion leads to the formation of reactive oxygen species (ROS) such as hydroxyl radicals, superoxide and hydrogen peroxide. Vitamin E has been widely used as an antioxidant; when administered in large doses it is deposited in the liver and then excreted in the bile, urine and feces. The objective of the present study was to evaluate the rate of excretion of fecal vitamin E in relation to its concentrations in serum and liver, and its role as a protective antioxidant against DNA damage induced by acute ethanol consumption. Wistar rats were divided into four groups receiving food and water ad libitum for 4 days plus the following treatments: Control (CG, n = 10 ) no treatment; Ethanol (ET, n = 10 ), receiving an acute ethanol dose intraperitoneally in the amount of 5 g/kg; vitamin E (VE, n = 10) receiving a high oral dose of vitamin E within the first three days in the amount of 100 tocopherol mg/kg body weight; ethanol plus vitamin E (VE + ET, n = 10 ) receiving both the ethanol and vitamin E doses. Higher concentrations of vitamin E were observed in the blood and liver of the animals in the groups that received vitamin E supplementation, independent of the presence or absence of ethanol. Concomitantly, these groups were also those with the highest concentration of the vitamin in the stool. The rate of DNA damage was higher in the groups that received ethanol with or without supplemental vitamin E. However, the rate of damage was lower in the group that received vitamin E supplementation than in the group that did not. The present results show that vitamin E has a protective effect against DNA damage induced by ethanol by reducing the extent of DNA damage.

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“…Antioxidants play an important role in preventing molecular and cellular damage caused by free radicals. Antioxidants such as vitamin C and N-acetyl cysteine have been shown to attenuate acute EtOH toxicity by lowering lipid peroxidation and GSH depletion up to a certain extent (Lee et al, 2013;Wang et al, 2006). PQQ has been shown to reduce acetaldehyde levels in blood after EtOH ingestion in rats (Hobara et al, 1988).…”

Section: Discussionmentioning

confidence: 99%

Pyrroloquinoline Quinone-Secreting ProbioticEscherichia coliNissle 1917 Ameliorates Ethanol-Induced Oxidative Damage and Hyperlipidemia in Rats

Singh

Pandey

Archana

2014

Alcohol Clin Exp Res

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Effects of vitamin C and E supplementation on oxidative stress and liver toxicity in rats fed a low-fat ethanol diet

Cited by 22 publications

References 41 publications

Palm tocotrienol-rich fraction inhibits methionine-induced cystathionine β-synthase in rat liver

Palm tocotrienol-rich fraction inhibits methionine-induced cystathionine β-synthase in rat liver

Oxidative Damage in Rats Receiving Ethanol and Supplemented with Vitamin E

Pyrroloquinoline Quinone-Secreting ProbioticEscherichia coliNissle 1917 Ameliorates Ethanol-Induced Oxidative Damage and Hyperlipidemia in Rats

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