Effects of Vitamin D on the Renin–Angiotensin System and Acute Childhood Pneumonia

Zovi, Andrea; Ferrara, Francesco; Pasquinucci, Roberta; Nava, Livia; Vitiello, Antonio; Arrigoni, Roberto; Ballini, Andrea; Cantore, Stefania; Palmirotta, Raffaele; Domenico, Marina Di; Santacroce, Luigì; Boccellino, Mariarosaria

doi:10.3390/antibiotics11111545

Cited by 4 publications

(2 citation statements)

References 49 publications

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“…Bacterial infections plagued human societies throughout history until the discovery of antibiotics [72][73][74][75][76], which led to adapt in different environments, the threat of antibiotics by means of different astute strategies [4,6,13,73]. They can modify the quaternary structure of a target protein, substitute a metabolic pathway by synthesizing alternative biomolecules, expel antibiotics from their cell by efflux pumps, produce enzymes able to inactivate the antibiotic, hide their target structure, for example, behind an outer capsule [76,[87][88][89]. Antimicrobial resistance genes may be carried on the bacterial gene chromosome, plasmid, or transposons [90][91][92][93][94][95].…”

Section: Antibiotic Resistance and Impact On Humansmentioning

confidence: 99%

The Role of Stakeholders’ Understandings in Emerging Antimicrobial Resistance: A One Health Approach

Nardulli,

Ballini,

Zamparella

et al. 2023

Microorganisms

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The increasing misuse of antibiotics in human and veterinary medicine and in agroecosystems and the consequent selective pressure of resistant strains lead to multidrug resistance (AMR), an expanding global phenomenon. Indeed, this phenomenon represents a major public health target with significant clinical implications related to increased morbidity and mortality and prolonged hospital stays. The current presence of microorganisms multi-resistant to antibiotics isolated in patients is a problem because of the additional burden of disease it places on the most fragile patients and the difficulty of finding effective therapies. In recent decades, international organizations like the World Health Organization (WHO) and the European Centre for Disease Prevention and Control (ECDC) have played significant roles in addressing the issue of AMR. The ECDC estimates that in the European Union alone, antibiotic resistance causes 33,000 deaths and approximately 880,000 cases of disability each year. The epidemiological impact of AMR inevitably also has direct economic consequences related not only to the loss of life but also to a reduction in the number of days worked, increased use of healthcare resources for diagnostic procedures and the use of second-line antibiotics when available. In 2015, the WHO, recognising AMR as a complex problem that can only be addressed by coordinated multi-sectoral interventions, promoted the One Health approach that considers human, animal, and environmental health in an integrated manner. In this review, the authors try to address why a collaboration of all stakeholders involved in AMR growth and management is necessary in order to achieve optimal health for people, animals, plants, and the environment, highlighting that AMR is a growing threat to human and animal health, food safety and security, economic prosperity, and ecosystems worldwide.

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Section: Antibiotic Resistance and Impact On Humansmentioning

confidence: 99%

The Role of Stakeholders’ Understandings in Emerging Antimicrobial Resistance: A One Health Approach

Nardulli,

Ballini,

Zamparella

et al. 2023

Microorganisms

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“…Probiotics such as Lactobacillus acidophilus and Bifidobacterium bifidum have been suggested to have anti-cancer properties and can help to reduce the side effects of chemotherapy and radiation therapy. Nutritional support supplements, such as omega-3 fatty acids, curcumin, and resveratrol, have also been studied for their potential to support anticancer therapy [ 9 , 10 , 11 ]. Different cellular and extracellular biochemical mechanisms can explain their effects on the survival of neoplastic cells, including epigenetic mechanisms that modulate the expression of genes involved in the stages of tumor promotion and progression [ 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

What Is the Role of Nutraceutical Products in Cancer Patients? A Systematic Review of Randomized Clinical Trials

et al. 2023

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Chemotherapy represents the main pharmacological cancer treatment. Recently, positive effects emerged with the combination of anticancer therapy and nutraceutical products. The aim of this systematic review is to collect and synthesize the available scientific evidence regarding the potential effects of nutraceuticals on cancer cells. A systematic literature search of randomized clinical trials of nutraceutical products in patients with cancer published up to 15 December 2022 was conducted using three data sources: Embase, PubMed, and Web of Science. The effect of high-dose isoflavone supplements on prostate cancer resulted in stabilization or reduction of PSA concentrations in 50% of isoflavone group patients six months after treatment. High doses of vitamin D supplementation plus chemotherapy in patients with advanced or metastatic colorectal cancer showed a median PFS of 13.0 months (95% CI, 10.1–14.7 months) for 49 patients. The effect of vitamin D supplementation on markers of inflammatory level and antioxidant capacity in women with breast cancer showed a significant increase in serum vitamin D concentration (28 ± 2.6 to 39 ± 3.5; p = 0.004) after 8 weeks of treatment. In conclusion, nutraceutical supplements represent a potentially growing sector and can be utilized in medical treatment or nutrition to provide integrated medical care.

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Current Views About the Link between SARS-CoV-2 and the Liver: Friends or Foe?

Lovero,

Charitos,

Topi

et al. 2024

EMIDDT

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The emergence of the novel coronavirus and the pandemic resulting from its spread have led to significant negative impacts on health, economy, relationships, and others. Particularly in the field of hospital care, the need for a greater number of patients has led to a breakdown of the system. Gastrointestinal manifestations are common in SARS-COV 2 patients, while 10% of those who are sick exhibit symptoms only from gastrointestinal without any manifestation on the part of the respiratory tract. The main manifestations are nausea, vomiting, diarrhoea, and anorexia. It is also interesting to note that biochemical liver disorder is a frequent finding and is associated with a worse prognosis and higher probability admission to intensive care. It was also observed that RNA from the virus was found in the stool several days after the tests came back negative pulmonary secretions, while rectal swab virus detection methods were used with a lower but comparable sensitivity to that of nasal swabs. Gastrointestinal symptoms in SARS-COV 2 infection are common and their search should be part of the initial diagnosis approach and have a connection with the gut microbiota dysbiosis and this can lead to an alteration of the gut/liver axis.

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Effects of Vitamin D on the Renin–Angiotensin System and Acute Childhood Pneumonia

Cited by 4 publications

References 49 publications

The Role of Stakeholders’ Understandings in Emerging Antimicrobial Resistance: A One Health Approach

The Role of Stakeholders’ Understandings in Emerging Antimicrobial Resistance: A One Health Approach

What Is the Role of Nutraceutical Products in Cancer Patients? A Systematic Review of Randomized Clinical Trials

Current Views About the Link between SARS-CoV-2 and the Liver: Friends or Foe?

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