Effects of Vitamin D on Fertility, Pregnancy and Polycystic Ovary Syndrome—A Review

Várbı́ró, Szabolcs; Takács, István; Tűű, László; Nas, Katalin; Sziva, Réka Eszter; Hetthéssy, Judit; Török, Marianna

doi:10.3390/nu14081649

Cited by 40 publications

(30 citation statements)

References 108 publications

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“…However, when there is not enough UV-B radiation, dietary vitamin D intake is also important (e.g., in Central Europe from October to March, or if someone does not spend enough time outdoors, uses sun protection creams, or wears clothing that fully covers the skin). With ageing, the rate of hydroxylation of vitamin D precursors in the body decreases, so the importance of exogenous vitamin D intake increases with age [ 83 , 84 ].…”

Section: Dietary Intervention Of Chronic Diseases In Menopausementioning

confidence: 99%

The Importance of Nutrition in Menopause and Perimenopause—A Review

Erdélyi,

Pálfi,

Tűű

et al. 2023

Nutrients

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Menopause is associated with an increased prevalence of obesity, metabolic syndrome, cardiovascular diseases, and osteoporosis. These diseases and unfavorable laboratory values, which are characteristic of this period in women, can be significantly improved by eliminating and reducing dietary risk factors. Changing dietary habits during perimenopause is most effectively achieved through nutrition counseling and intervention. To reduce the risk factors of all these diseases, and in the case of an already existing disease, dietary therapy led by a dietitian should be an integral part of the treatment. The following review summarizes the recommendations for a balanced diet and fluid intake, the dietary prevention of cardiovascular diseases, the role of sleep, and the key preventive nutrients in menopause, such as vitamin D, calcium, vitamin C, B vitamins, and protein intake. In summary, during the period of perimenopause and menopause, many lifestyle factors can reduce the risk of developing all the diseases (cardiovascular disease, insulin resistance, type 2 diabetes mellitus, osteoporosis, and tumors) and symptoms characteristic of this period.

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Section: Dietary Intervention Of Chronic Diseases In Menopausementioning

confidence: 99%

The Importance of Nutrition in Menopause and Perimenopause—A Review

Erdélyi,

Pálfi,

Tűű

et al. 2023

Nutrients

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“…In women with PCOS, vitamin D deficiency has been tied to menstrual irregularity, insulin resistance and hyperandrogenemia [35–37]. There is a vitamin D response element in the promoter region of the insulin gene, and vitamin D receptor polymorphisms have been studied as a proposed cause for the relationship between vitamin D serum levels, insulin resistance and hyperandrogenism [38].…”

Section: Vitamin D and Polycystic Ovarian Syndromementioning

confidence: 99%

Vitamin D and infertility

Simpson

Pal

2023

Current Opinion in Obstetrics &Amp; Gynecology

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Purpose of reviewVitamin D deficiency has been implicated as a contributing factor to a spectrum of reproductive health burden, including difficulty conceiving, pathogenesis of gynaecological disorders such as uterine fibroids and endometriosis, to metabolic and endocrine burden of polycystic ovarian syndrome (PCOS). Recent findingsThere have been recent publications showing that in infertile women who are supplemented with vitamin D, there are higher pregnancy rates; there are improved ovarian reserve parameters in women with diminished ovarian reserve; curtailed fibroid growth in those with uterine myomas; lessened dysmenorrhea in endometriosis patients; and improved menstrual regularity, lowered testosterone, AMH and insulin levels in women with PCOS. In infertile men, sperm parameters, especially motility, are positively correlated with vitamin D serum levels. SummaryVitamin D status appears to be relevant to reproductive physiology, and to physiological processes underlying common gynaecological disorders as well as for reproductive success.

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“…In addition to hyperandrogenemia and high central fat deposition, low serum vitamin D (VD) levels may also play a role in the etiology of low-grade chronic inflammation in PCOS [ 16 , 24 ]. The fact that serum VD levels are reported to be low in most studies in PCOS suggests that this secosteroid hormone and its receptor may play a role in ovulatory dysfunction and cumulus expansion defect [ 25 , 26 ]. Indeed, VDR is widely expressed not only in tissues involved in calcium metabolism but also in CCs [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Long pentraxin 3 and vitamin D receptor mRNA expression pattern of cumulus granulosa cells isolated from PCOS oocytes at different stages of nuclear maturation

Ersahin,

Celik,

Gungor

et al. 2024

Reprod Biol Endocrinol

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Background A fine-tuned pro-inflammatory and anti-inflammatory balance in the follicular unit is essential for cumulus expansion and successful ovulation. While the long pentraxin 3 (PTX3) gene is required for the expansion of cumulus cells (CCs), ovulation, resumption of meiosis and fertilization, the vitamin D receptor gene (VDR-X2) is required for intra-follicle redox balance. This study was planned to determine the expression pattern of VDR-X2 and PTX3 mRNA in CCs isolated from germinal vesicle (GV), metaphase I (MI), and metaphase II (MII) oocytes of PCOS patients with ovulatory dysfunction. Methods The relative expression of CC-PTX3 and CC-VDR-X2 mRNA were evaluated using qRT-PCR in a total of 79 CC samples collected from individual cumulus-oocyte complex of 40 infertile patients (20 PCOS and 20 non-PCOS normal responders) who underwent ovarian stimulation with the GnRH antagonist protocol. Results Relative PTX3 mRNA expressions of CCMI-control and CCMII-control showed 3- and 9-fold significant upregulation compared to CCGV-control, respectively. The relative PTX3 mRNA expression of CCMII-control increased approximately three fold compared to CCMI-control. Compared to CCGV-pcos, a 3-fold increase was noted in the relative PTX3 mRNA expression of CCMI-pcos and an approximately 4-fold increase in the PTX3 mRNA expression of CCMII-pcos. Relative PTX3 mRNA expression values of CCMII-pcos and CCMI-pcos were similar. A 6-fold upregulation of relative PTX3 mRNA and a 4-fold upregulation of VDR-X2 mRNA were detected in CCMII-control compared to CCMII-pcos. CC-VDR-X2 expression patterns of the PCOS and control groups overlapped with the CC-PTX3 pattern. Fertilization rates of the PCOS group exhibiting failed transcript expression were similar to normal responders. Conclusion The fact that relative CC-PTX3 and CC-VDR mRNA expression does not increase during the transition from MI to MII stage in PCOS as in normal responders suggests that PTX3 and VDR expression may be defective in cumulus cells of PCOS patients with ovulatory dysfunction.

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Effects of Vitamin D on Fertility, Pregnancy and Polycystic Ovary Syndrome—A Review

Cited by 40 publications

References 108 publications

The Importance of Nutrition in Menopause and Perimenopause—A Review

The Importance of Nutrition in Menopause and Perimenopause—A Review

Vitamin D and infertility

Long pentraxin 3 and vitamin D receptor mRNA expression pattern of cumulus granulosa cells isolated from PCOS oocytes at different stages of nuclear maturation

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