Effects of Vitamin D Supplementation on Surrogate Markers of Fertility in PCOS Women: A Randomized Controlled Trial

Lerchbaum, Elisabeth; Theiler‐Schwetz, Verena; Kollmann, Markus; Wölfler, M; Pilz, Stefan; Obermayer–Pietsch, Barbara; Trummer, Christian

doi:10.3390/nu13020547

Cited by 23 publications

(23 citation statements)

References 41 publications

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“…Regarding VD pretreatment (conventional medication 2000 IU-5000 IU/week, continuous medication for 2 weeks to 6 months), a total of 7 articles [ 46 – 52 ] were included (total number of sample cases n = 316, 9 groups of self-controlled studies) (Table S 5 ). REM analysis of 9 sets of data ( n = 316) showed that VD pretreatment (2 weeks to 6 months) in patients caused an increase in serum AMH (WMD: 0.78, 95%CI: 0.34 to 1.21; P = 0.0004) (Fig.…”

Section: Resultsmentioning

confidence: 99%

The effect of medication on serum anti-müllerian hormone (AMH) levels in women of reproductive age: a meta-analysis

et al. 2022

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Objective The study aims to address whether serum anti-müllerian hormone (AMH) levels fluctuate in the short term after medication application, including oral contraceptives (OCs), metformin (MET), Gonadotropin-releasing hormone agonist (GnRH-a), dehydroepiandrosterone (DHEA), vitamin D (VD), clomiphene citrate (CC), and letrozole (LET). Methods Published literature from PubMed, Embase, and Cochrane central was retrieved up until 19 September 2021. A total of 51 self-control studies with an average Newcastle–Ottawa quality assessment scale (NOS) score of 6.90 were analyzed. The extracted data were entered into Stata software, and the weighted mean difference/standardized mean difference (WMD/SMD) and 95% confidence interval (CI) were used for data analysis. Results After OCs treatment the AMH level showed a significant decline in women with normal ovarian function, which was significant within 3 months (WMD = -1.43, 95% CI: -2.05 to -0.80, P < 0.00001). After MET treatment, the serum AMH decreased in polycystic ovary syndrome (PCOS) patients (WMD = -1.79, 95% CI: -2.32 to -1.26, P < 0.00001), in both obese and non-obese patients. GnRH-a treatment in endometriosis patients led to dynamic changes in the serum AMH levels, that is, ascent at 1 month (P = 0.05), and descent at 3 months (P = 0.02). After DHEA treatment the serum AMH increased in diminished ovarian reserve (DOR) / poor ovarian response (POR) patients (WMD = 0.18, 95% CI: 0.09 to 0.27, P < 0.0001). After VD treatment the serum AMH increased, and it was obvious in non-PCOS patients (WMD = 0.78, 95% CI: 0.34 to 1.21, P = 0.0004). After CC treatment the serum AMH decreased significantly in PCOS patients, specifically in non-obese patients (WMD = -1.24, 95% CI: -1.87 to -0.61, P = 0.0001). Conclusions Serum AMH levels may be affected in the short term after drug application. Specifically, OC, MET and CC lead to decreased AMH level, DHEA and VD lead to increased AMH level, and GnRH-a leads to dynamic variation, which is correlated with PCOS, obesity, age, and duration of medication. The impacts of these medications should be taken into consideration when AMH is used as a marker of ovarian reserve.

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Section: Resultsmentioning

confidence: 99%

The effect of medication on serum anti-müllerian hormone (AMH) levels in women of reproductive age: a meta-analysis

et al. 2022

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“…Serum samples from twenty women with a diagnosis of PCOS (PCOS group) and from a further twenty women without PCOS (subfertile group) along with up to ten FF per patient were included in the analyses. PCOS was diagnosed according to the Rotterdam criteria as described [29,30], and a set of relevant clinical characteristics were determined (Table 1). At the time of sampling, 8 women in the subfertile and 15 in the PCOS group were diagnosed as primary infertile.…”

Section: Study Populationmentioning

confidence: 99%

Pronounced Trace Element Variation in Follicular Fluids of Subfertile Women Undergoing Assisted Reproduction

Schmalbrock

Weiss²,

Rijntjes

et al. 2021

Nutrients

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Female subfertility is a growing concern, especially in view of an increasing prevalence of polycystic ovary syndrome (PCOS). Assisted reproductive technologies (ART) offer a perspective for pregnancy, but the outcome rate is still suboptimal. The trace elements (TE), copper (Cu), selenium (Se), and zinc (Zn) are essential for fertility and development. We hypothesized that TE concentrations are related to oocyte quality and growth and affect pregnancy outcomes in women undergoing ART. Concentrations of TE were measured by total reflection X-ray fluorescence. Extracellular glutathione peroxidase 3 (GPX3) and selenoprotein P (SELENOP) were determined as additional Se biomarkers. Corresponding serum and follicular fluid (FF) samples were available from women with (n = 20) and without (n = 20) PCOS diagnosis undergoing hormone treatment within the ART procedure, respectively, and FF samples were classified into five groups based on morphological assessment. Serum showed higher TE concentrations than FF, and TE levels correlated positively between both matrices. Individual FF from the same women showed surprisingly high variability in TE concentration, and follicles without oocytes displayed the lowest TE concentrations. Both Se biomarkers GPX3 and SELENOP were present in FF and correlated positively to Se concentrations. Some notable relationships were observed between morphokinetic parameters, TE concentrations, and GPX3 activity. A slightly depressed serum Zn concentration was observed in PCOS. Our results indicate a direct relationship between TE in serum and FF, positive correlations between the three Se biomarkers in FF, and high variability between the FF from the same woman with the lowest TE concentrations in the follicles with the poorest quality. The differences observed in relation to PCOS diagnoses appear relatively minor. Collectively, the data support the notion that TE assessment of follicles may contribute to optimal oocyte selection and subsequently influence ART success.

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“…A study by Samantha F Butts et al found that ovulation and live birth rates were 15.2% and 40% lower, respectively, in VD deficient PCOS patients than in normal women [114]. Recent studies have shown that VD supplementation can increase FSH levels in PCOS patients, thereby decreasing LH/FSH values, and improving IR and hyperlipidemia, thus increasing ovulation and pregnancy rates in PCOS patients [115,116]. Severe OS is one of the causes of PCOS.…”

Section: Clinical Observation and Mechanism Of Supplementingmentioning

confidence: 99%

The Application of Complementary and Alternative Medicine in Polycystic Ovary Syndrome Infertility

Shi

Wang

Zhu

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Polycystic ovary syndrome (PCOS) is a lifelong reproductive endocrine disease, which is the most common cause of anovular infertility. Modern medicine mainly treats infertile patients with PCOS by improving living habits, ovulation induction therapy, and assisted reproductive technology (ART), but the effect is not satisfied. Complementary alternative medicine (CAM) has conspicuous advantages in the treatment of PCOS infertility due to its good clinical efficacy, wide mechanism of action, and no obvious adverse reactions, but its safety and effectiveness in the treatment of PCOS infertility have not been proved. Based on the existing clinical and experimental studies, this paper looks for the therapeutic effect and the mechanism behind it, and explores the safety and effectiveness of its treatment in PCOS infertility, in order to provide reference for future clinical treatment and experimental research.

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Effects of Vitamin D Supplementation on Surrogate Markers of Fertility in PCOS Women: A Randomized Controlled Trial

Cited by 23 publications

References 41 publications

The effect of medication on serum anti-müllerian hormone (AMH) levels in women of reproductive age: a meta-analysis

The effect of medication on serum anti-müllerian hormone (AMH) levels in women of reproductive age: a meta-analysis

Pronounced Trace Element Variation in Follicular Fluids of Subfertile Women Undergoing Assisted Reproduction

The Application of Complementary and Alternative Medicine in Polycystic Ovary Syndrome Infertility

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