Effects of vitamin D supplementation in women with polycystic ovary syndrome: a review

Menichini, Daniela; Facchinetti, Fabio

doi:10.1080/09513590.2019.1625881

Cited by 54 publications

(41 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…41,42 Although several interventional studies have explored the causality of this linkage, a consistent conclusion has still not been reached. Recently, Menichini et al 43 summarized that serum TG was significantly decreased after VitD intervention in four RCTs with PCOS patients, while no changes were found in LDL-C, HDL-C, and TC. However, this conclusion was based on a systematic review without statistical support.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Influence of vitamin D supplementation on lipid levels in polycystic ovary syndrome patients: a meta-analysis of randomized controlled trials

Jin

Qian

et al. 2020

J Int Med Res

View full text Add to dashboard Cite

Objective Observational studies have shown that circulating vitamin D (VitD) deficiency is associated with atherogenic lipid patterns among polycystic ovary syndrome (PCOS) patients. However, interventional studies have shown inconsistent results. The aim of this meta-analysis was to investigate how VitD supplementation influences lipid indices in PCOS patients. Methods The authors searched four electronic databases through August 2019 to identify randomized controlled trials (RCTs) that assessed the effect of VitD intervention on serum lipids among PCOS patients. Mean differences were generated for statistical evaluation. Results We included eight studies and performed nine comparisons across 467 participants. VitD supplementation reduced serum triglyceride levels (−11.88 mg/dL; 95% confidence interval [CI]: −17.03 to −6.73), total cholesterol (−9.09 mg/dL; 95% CI: −14.90 to −3.29), low-density lipoprotein cholesterol (−5.22 mg/dL; 95% CI: −10.32 to −0.13), and very-low-density lipoprotein cholesterol (−2.43 mg/dL; 95% CI: −3.69 to −1.17) compared with no VitD supplementation. However, high-density lipoprotein cholesterol levels showed no differences with or without VitD supplementation (−0.39 mg/dL; 95% CI: −1.39 to 0.61). Conclusions VitD supplementation improved serum lipid levels among PCOS patients, but serum high-density lipoprotein cholesterol levels were not changed. VitD intervention might benefit PCOS patients who are at high risk of an atherogenic lipid profile.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Recently, Menichini et al. 43 summarized that serum TG was significantly decreased after VitD intervention in four RCTs with PCOS patients, while no changes were found in LDL-C, HDL-C, and TC. However, this conclusion was based on a systematic review without statistical support.…”

Section: Discussionmentioning

confidence: 99%

Influence of vitamin D supplementation on lipid levels in polycystic ovary syndrome patients: a meta-analysis of randomized controlled trials

Jin

Qian

et al. 2020

J Int Med Res

View full text Add to dashboard Cite

show abstract

“…Recent systematic review and meta-analysis of randomized controlled trials suggest a possible benefit of vitamin D supplementation for follicular development and regulation of the menstrual cycle in PCOS patients [40] . In a randomized control trial involving 90 insulin-resistant PCOS patients, high-dose vitamin D (4000 IU) had beneficial effects on total testosterone, sex hormone-binding globulin, free androgen index, serum hs-CRP, and plasma total antioxidant capacity levels compared with low-dose vitamin D (1000 IU) and placebo groups [41] , [42] . Co-supplementation with calcium and vitamin D (Ca 1000 mg/day, vitamin D 6000 IU/day during 8 weeks) was shown to significantly improve menstrual cycle regularity when added to metformin (1500 mg/day) in the randomized placebo-controlled clinical trial in 40 vitamin D-deficient PCOS patients [43] .…”

Section: Discussionmentioning

confidence: 99%

Lifestyle management of polycystic ovary syndrome: a single-center study in Bosnia and Herzegovina

et al. 2020

View full text Add to dashboard Cite

Background Polycystic ovary syndrome (PCOS) is a complex endocrinopathy affecting up to 20% of pre-menopausal women. The most recent international guidelines set lifestyle management as the cornerstone of the PCOS treatment. Still, there is a paucity of data on the implementation of lifestyle management in clinical practice. This cross-sectional study aimed to explore physicians-reported practices in PCOS lifestyle management in the Sarajevo Canton, Bosnia and Herzegovina (BiH). The profession of dietetics is not legally recognized in BiH. Nutritional interventions in health promotion and disease treatment are provided by medical professionals. Methods Data were collected by a paper-based questionnaire distributed during March-May 2018 in the Public Institution Health Centre of Sarajevo Canton. Results Forty-six physicians (response rate of 80.7%) completed the questionnaire. An initial treatment plan based solely on lifestyle measures (diet + physical activity), as recommended by current guidelines was reported by 34.8% of physicians. Although dietary interventions were rated as highly relevant in PCOS management by the vast majority of physicians, only one-half reported recording patients' adherence and 45.7% of physicians were unsure of the effectiveness of the lifestyle interventions in their patients. Conclusion PCOS lifestyle management in the study setting is sub-optimal. Additional education on effective PCOS lifestyle management strategies would be beneficial, especially for physicians with less than 15 years in practice. Possible obstacles to better physicians' engagement in PCOS lifestyle management should be further investigated.

show abstract

“…I tak u kobiet w wieku pomenopauzalnym stężenie 25(OH)D było istotnie niższe niż wśród kobiet z ZM przed menopauzą. Dane te potwierdziły wcześniejsze obserwacje autorów tego artykułu i innych badaczy [24,25].…”

Section: Omówienieunclassified

Assessment of 25(OH)D concentration in people with metabolic syndrome working in agriculture

Godala

Gaszyńska

Moczulski

et al. 2020

Med Pr

View full text Add to dashboard Cite

Wstęp: Dane dotyczące stanu odżywienia witaminą D populacji polskiej są niepełne. Niedobory witaminy D wydają się powszechne, jednak nie odnaleziono polskich badań, które weryfikowałyby stężenie 25-hydroksywitaminy D [25(OH)D] u osób intensywnie eksponowanych na promieniowanie ultrafioletowe (UV). Celem pracy była ocena stężenia 25(OH)D w osoczu osób z zespołem metabolicznym (ZM) pracujących w rolnictwie, częstość jej niedoborów u tych osób oraz zależność między stężeniem 25(OH)D w osoczu a tradycyjnymi biomarkerami chorób sercowo-naczyniowych. Materiał i metody: W badaniu wzięło udział 332 mieszkańców województwa łódzkiego pracujących w rolnictwie, w tym 231 osób z ZM i 101 zdrowych. Stężenie 25(OH)D w osoczu oceniano z użyciem testu wykorzystującego technologię chemiluminescencyjnych testów immunologicznych. Spożycie witaminy D z dietą oceniano za pomocą programu Dieta 5.0 na podstawie 24-godzinnych wywiadów żywieniowych. Wyniki: Średnie stężenie 25(OH)D w osoczu pracowników z ZM wynosiło 13,64±8,01 ng/ml i było istotnie niższe niż w grupie badanych bez ZM (26,61±10,12 ng/ml, p < 0,00001). Najwyższe średnie stężenie 25(OH)D odnotowano w miesiącach letnich. U pracowników z ZM istotnie częściej niż w grupie bez ZM stwierdzono deficytowe stężenie 25(OH)D w osoczu (odpowiednio, 81,82% i 20,79%, p < 0,00001). Stwierdzono brak korelacji między stężeniem 25(OH)D a jej spożyciem z dietą. Stężenie 25(OH)D korelowało z wiekiem (r =-0,28, p = 0,023) oraz stężeniami cholesterolu HDL (r = 0,19, p = 0,036) i glukozy (Rho =-0,24, p = 0,02) w badanej grupie rolników. Wieloczynnikowa analiza wariancji wykazała, że u pracowników z ZM czynnikiem wpływającym istotnie na średnią wartość stężenia 25(OH)D był wskaźnik masy ciała. Wnioski: Stężenie witaminy D w osoczu osób z ZM było istotnie mniejsze niż u osób zdrowych mimo jednakowej, wysokiej ekspozycji na promieniowanie UV. Ponadto u osób z ZM istotnie częściej stwierdzano deficytowe stężenie 25(OH)D niż u badanych bez ZM. Uzyskane wyniki wskazują na konieczność prowadzenia dalszych badań dotyczących stężenia 25(OH)D u osób z chorobami metabolicznymi, niezależnie od wielkości ekspozycji na promieniowanie UV i spożycia witaminy D z dietą. Med. Pr. 2021;72(1)

show abstract

Effects of vitamin D supplementation in women with polycystic ovary syndrome: a review

Cited by 54 publications

References 29 publications

Influence of vitamin D supplementation on lipid levels in polycystic ovary syndrome patients: a meta-analysis of randomized controlled trials

Influence of vitamin D supplementation on lipid levels in polycystic ovary syndrome patients: a meta-analysis of randomized controlled trials

Lifestyle management of polycystic ovary syndrome: a single-center study in Bosnia and Herzegovina

Assessment of 25(OH)D concentration in people with metabolic syndrome working in agriculture

Contact Info

Product

Resources

About