Effects of Vitamin D Supplementation on the Functional Outcome in Patients With Osteoporotic Vertebral Compression Fracture and Vitamin D Deficiency

Ko, Sangbong; Jun, Chung-Mu; Nam, Jun Ho

doi:10.21203/rs.3.rs-596496/v1

Cited by 1 publication

(7 citation statements)

References 17 publications

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“…A fnal total of 14 studies, assessing a total of 2734 patients, were included to assess fracture outcomes following vitamin D supplementation [10,14,[23][24][25][26][27][28][29][30][31][32][33][34]. Nine of these were controlled trials of which seven were randomised and two were nonrandomised.…”

Section: Resultsmentioning

confidence: 99%

“…Tere was a wide variation in vitamin D supplementation techniques amongst the studies. Te research identifed bolus dosing regimens ranging from 100,000 to 300,000 IU [14,27,28], daily dosing regimens ranging from 800 to 2000 IU daily [23][24][25][29][30][31], or a combination of bolus and daily dosing [26,33,34]. Supplementation forms included oral tablet, liquid drops, or intramuscular injections.…”

Section: Supplementation Strategymentioning

confidence: 99%

“…Vitamin D3 was used for supplementation in all studies except for Hiokka et al who used alfacalcidol [10]. [14,24,27,[31][32][33][34]. Tere were two studies which did not distinguish between the union types [28,32].…”

Section: Supplementation Strategymentioning

confidence: 99%

“…Tere were two studies which did not distinguish between the union types [28,32]. Of the remaining studies, four reported both radiological and clinical outcomes [14,31,33,34], while two studies reported only radiological outcomes [24,27]. Tere were fve studies which reported no signifcant diference in complication rates when supplementing fracture patients [14,24,27,32,34].…”

Section: Supplementation Strategymentioning

confidence: 99%

“…Of the remaining studies, four reported both radiological and clinical outcomes [14,31,33,34], while two studies reported only radiological outcomes [24,27]. Tere were fve studies which reported no signifcant diference in complication rates when supplementing fracture patients [14,24,27,32,34]. Te overall quality of these studies was rated as "low risk of bias" for the controlled trials and "fair quality" for the observational studies (Figures 2 and 3 and Table 2).…”

Section: Supplementation Strategymentioning

confidence: 99%

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The Effect of Vitamin D Supplementation for Bone Healing in Fracture Patients: A Systematic Review

Gatt

Grech

Arshad

2023

Advances in Orthopedics

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While most literature on vitamin D supplementation in fracture patients focuses on fracture prevention, the effect of vitamin D on bone healing is a much less studied concept. The primary aim of this systematic review was to assess whether vitamin D supplementation in fracture patients improves clinical or radiological union complications. The secondary aims were to assess supplementation effect on patient functional outcome scores and bone mineral density (BMD). A systematic search of all relevant articles was performed using the following databases: MEDLINE, Embase, Google Scholar, and Web of Science. The population selection included human patients with a fresh fracture treated conservatively or operatively. The intervention included any form of vitamin D supplementation, compared to no supplementation or a placebo. The primary outcomes assessed were clinical or radiological union rates or complications arising from the nonunion. The secondary outcomes assessed were functional outcome scores, BMD scores after treatment, and pain scores. A total of fourteen studies, assessing a total of 2734 patients, were included. Eight studies assessed the effect of vitamin D on clinical or radiological union. Five studies reported no significant difference in complication rates when supplementing fracture patients. Alternatively, three studies reported a positive effect with supplementation between the groups. One of these studies found a difference only for early orthopaedic complications (<30 days), but no differences in late complications. The other two studies found significant differences in clinical union; however, no changes were observed in radiological union. Six studies investigated functional outcome scores after supplementation. Four of these studies found no significant differences between most functional outcome scores. Only three studies reported BMD outcomes, one of which found limited effect on total hip BMD. The overall findings are that vitamin D alone does little to influence fracture healing and subsequent union rates or functional outcome. The studies suggestive of a positive effect were generally of a lower quality. Further high quality RCTs are needed to justify routine supplementation at the time of fracture.

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