Effects of vitamin D supplementation on neuroplasticity in older adults: a double-blinded, placebo-controlled randomised trial

Pirotta, Stephanie; Kidgell, Dawson; Daly, Robin M.

doi:10.1007/s00198-014-2855-6

Cited by 42 publications

(47 citation statements)

References 35 publications

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“…This is in line with previous studies that found associations of BDNF and vitamin D or vitamin D supplementation with depression but reported no interactions between the measures [64, 65]. In summary, our hypothesis of an interaction between vitamin D and BDNF with obesity was not confirmed.…”

Section: Discussioncontrasting

confidence: 43%

Association of Brain-Derived Neurotrophic Factor and Vitamin D with Depression and Obesity: A Population-Based Study

et al. 2017

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Background: Depression and obesity are widespread and closely linked. Brain-derived neurotrophic factor (BDNF) and vitamin D are both assumed to be associated with depression and obesity. Little is known about the interplay between vitamin D and BDNF. We explored the putative associations and interactions between serum BDNF and vitamin D levels with depressive symptoms and abdominal obesity in a large population-based cohort. Methods: Data were obtained from the population-based Study of Health in Pomerania (SHIP)-Trend (n = 3,926). The associations of serum BDNF and vitamin D levels with depressive symptoms (measured using the Patient Health Questionnaire) were assessed with binary and multinomial logistic regression models. The associations of serum BDNF and vitamin D levels with obesity (measured by the waist-to-hip ratio [WHR]) were assessed with binary logistic and linear regression models with restricted cubic splines. Results: Logistic regression models revealed inverse associations of vitamin D with depression (OR = 0.966; 95% CI 0.951–0.981) and obesity (OR = 0.976; 95% CI 0.967–0.985). No linear association of serum BDNF with depression or obesity was found. However, linear regression models revealed a U-shaped association of BDNF with WHR (p < 0.001). Conclusion: Vitamin D was inversely associated with depression and obesity. BDNF was associated with abdominal obesity, but not with depression. At the population level, our results support the relevant roles of vitamin D and BDNF in mental and physical health-related outcomes.

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Section: Discussioncontrasting

confidence: 43%

Association of Brain-Derived Neurotrophic Factor and Vitamin D with Depression and Obesity: A Population-Based Study

et al. 2017

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“…Both season and latitude can be important covariates as a result of internal vitamin D production by ultraviolet‐B radiation . The season of blood withdrawal was not stated in six of the 15 studies and the geographic latitude was stated in three . Other covariates of vitamin D status (body mass index, ethnicity, smoking) were usually not considered specifically.…”

Section: Resultsmentioning

confidence: 99%

Vitamin D supplementation and its influence on muscle strength and mobility in community‐dwelling older persons: a systematic review and meta‐analysis

Rosendahl-Riise

Spielau

Ranhoff

et al. 2016

J Human Nutrition Diet

116

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BackgroundIt has been suggested that vitamin D status or supplementation is important for maintaining or improving muscle strength and mobility in older adults. The study results, however, do not provide consistent results. We therefore aimed to summarise the available evidence systematically, including only studies conducted in community‐dwelling older persons.MethodsA systematic search of the literature was performed in April of 2016. The systematic review includes studies that used vitamin D with or without calcium supplementation as the exposure variable and various measurements of muscle strength and mobility. The meta‐analysis was limited to studies using hand grip strength (HGS) and timed‐up‐and‐go test as the outcome variables.ResultsA total of 15 studies out of 2408 articles from the literature search were included in the systematic review, providing 2866 participants above the age of 65 years. In the majority of studies, no improvement in muscle strength and mobility was observed after administration of vitamin D with or without calcium supplements. In the meta‐analysis, we observed a nonsignificant change in HGS [+0.2 kg (95% confidence interval = −0.25 to 0.7 kg; seven studies)] and a small, significant increase in the timed‐up‐and‐go test [0.3 s (95% confidence interval = 0.1 to 0.5 s; five studies)] after vitamin D supplementation. The meta‐analyses showed a high degree of heterogeneity between the studies.ConclusionsIn conclusion, we observed no improvement in muscle strength after the administration of vitamin D with or without calcium supplements. We did find a small but significant deterioration of mobility. However, this is based on a limited number of studies and participants.

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“…37 What is more, vitamin D affects neuroplasiticity, a process via which neural synapses and pathways are adapted to the needs of environmental and behavioral demands, adjusting the brain to noxious stimuli diseases or environmental cues. 38,39 Moreover, vitamin D affects GABAergic neurons in the motor cortex, 40 GABAergic function being the principal "brake" within the brain affecting muscle relaxation via the corticospinal neurons. 41 of particular note, GABAergic, serotonin and dopamine neurons are crucial in muscular coordination and the avoidance of central fatigue, 42 a high ratio of serotonin to dopamine positively impacting exercise performance because of serotonin's effect on the general feeling of tiredness and the perceptions of effort.…”

Section: Effects Of Vitamin D On the Nervous Systemmentioning

confidence: 99%

Muscular effects of vitamin D in young athletes and non-athletes and in the elderly

Koundourakis¹,

Avgoustinaki²,

Malliaraki³

et al. 2017

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Effects of vitamin D supplementation on neuroplasticity in older adults: a double-blinded, placebo-controlled randomised trial

Cited by 42 publications

References 35 publications

Association of Brain-Derived Neurotrophic Factor and Vitamin D with Depression and Obesity: A Population-Based Study

Association of Brain-Derived Neurotrophic Factor and Vitamin D with Depression and Obesity: A Population-Based Study

Vitamin D supplementation and its influence on muscle strength and mobility in community‐dwelling older persons: a systematic review and meta‐analysis

Muscular effects of vitamin D in young athletes and non-athletes and in the elderly

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