Effects of vitamin D supplementation on inflammatory response in patients with cancer and precancerous lesions: Systematic review and meta-analysis of randomized trials

Gwenzi, Tafirenyika; Zhu, Anna; Schrotz‐King, Petra; Schöttker, Ben; Hoffmeister, Michael; Brenner, Hermann

doi:10.1016/j.clnu.2023.05.009

Cited by 9 publications

(1 citation statement)

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“…This balance is essential for preventing chronic inflammation, which is associated with cancer development. VitD has anti-inflammatory properties, and, thus, by reducing inflammation, VitD may help prevent the progression of OPMDs to oral cancer [114][115][116][117].…”

Section: Vitamin D and Opmdsmentioning

confidence: 99%

The Magic Triangle in Oral Potentially Malignant Disorders: Vitamin D, Vitamin D Receptor, and Malignancy

Khamis,

Salzer,

Schiegnitz

et al. 2023

IJMS

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OPMDs (oral potentially malignant disorders) are a group of disorders affecting the oral mucosa that are characterized by aberrant cell proliferation and a higher risk of malignant transformation. Vitamin D (VitD) and its receptor (VDR) have been extensively studied for their potential contributions to the prevention and therapeutic management of various diseases and neoplastic conditions, including oral cancer. Observational studies suggest correlations between VitD deficiency and higher cancer risk, worse prognosis, and increased mortality rates. Interestingly, emerging data also suggest a link between VitD insufficiency and the onset or progression of OPMDs. Understanding the role of the VitD–VDR axis not only in established oral tumors but also in OPMDs might thus enable early detection and prevention of malignant transformation. With this article, we want to provide an overview of current knowledge about OPMDs and VitD and investigate their potential association and ramifications for clinical management of OPMDs.

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Section: Vitamin D and Opmdsmentioning

confidence: 99%