Effects of vitamin D supplementation on circulatory YKL-40 and MCP-1 biomarkers associated with vascular diabetic complications: A randomized, placebo-controlled, double-blind clinical trial

Omidian, Mahsa; Mahmoudi, Maryam; Javanbakht, Mohammad Hassan; Eshraghian, Mohammad Reza; Abshirini, Maryam; Daneshzad, Elnaz; Hasani, Hossein; Alvandi, Ehsan; Djalali, Mahmoud

doi:10.1016/j.dsx.2019.07.047

Cited by 23 publications

(15 citation statements)

References 34 publications

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“…Pathogenic stimuli induce TNFa expression, which in turn induces other mediators and proteases responsible for the inflammatory response 68 . Omidian 69 , supplementing diabetic patients with 4,000 IU/day of vitamin D for 3 months, found a significant difference in serum TNFa levels, showing the possible protective effect that this micronutrient can have on inflammation when used in larger dosages and for a prolonged period. Borges 70 showed an association between vitamin D deficiency and reduced beta-oxidation markers, including PPARa .…”

Section: Discussionmentioning

confidence: 99%

The impact of vitamin D supplementation on VDR gene expression and body composition in monozygotic twins: randomized controlled trial

Medeiros

Borges

Soares

et al. 2020

Sci Rep

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Vitamin D supplementation is widely used. However, there is no consensus on the use and dosage of this supplement and the existing recommendations arise from studies based on the benefits that this nutrient can facilitate in bones. In addition, individual genetics can influence the response to supplementation, therefore, research involving monozygotic twins aims to reduce these differences in phenotypic responses. The objective of this randomised controlled study is to examine the effect of vitamin D supplementation on body composition and the expression of the vitamin D receptor (VDR) mRnA. An intervention was performed through supplementation with cholecalciferol at the concentration of 2000 IU in 90 healthy adult monozygotic twins (male or female pairs) for 2 months. The findings showed that serum vitamin D concentration increased by 65% and VDR gene expression sixty times (p = 0.001). Changes in body composition parameters were observed regarding body fat and lean mass. our results indicate that an increase in serum vitamin D concentration may have potential therapeutic implications. Supplementation with vitamin D (cholecalciferol) has become a widely used practice, since a relationship has been demonstrated of low levels of this nutrient with the increased risk of cardiovascular diseases, the recurrence of diseases, and mortality 1,2,3. However, as there is no consensus on sufficient serum levels of vitamin D, taking into account its non-skeletal functions, it is necessary to assess whether the increase in this nutrient in individuals with 25-hydroxyvitamin D (25 (OH) D) levels above the current cutoff point, generates any health benefits 4. Vitamin D is involved in several non-skeletal functions, such as cell regulation, differentiation, and growth 3 , and adaptive and innate immunity control 5 , as well as being associated with inflammatory markers 6 , since the vitamin D receptor (VDR) is expressed in almost all human cells 7. The activity of this nutrient in the human organism involves its binding with VDR 8 , whose expression is modulated by the blood levels of the 1,25diidroxivitamin D (1,25 (OH) 2D) 9 and genetic variants 10. It is believed that there is a negative correlation between the concentration of 25 (OH) D with the body mass index (BMI) and percentage of fat mass 11. However, few studies have comprehensively evaluated the effect of

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Section: Discussionmentioning

confidence: 99%

The impact of vitamin D supplementation on VDR gene expression and body composition in monozygotic twins: randomized controlled trial

Medeiros

Borges

Soares

et al. 2020

Sci Rep

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“…O presente estudo revelou efeitos favoráveis associados à suplementação dietética com vitamina D. De modo geral, a revisão sistemática dos estudos observacionais apontou a vitamina supracitada como um fator capaz de alterar dos marcadores de risco cardiovascular em pacientes portadores de diabetes mellitus tipo II, que por consequência acarreta em uma diminuição de complicações microvasculares (Shab-Bidar et al, 2011;Omidian et al, 2019).…”

Section: Discussionunclassified

Uso da vitamina D para a diminuição do risco cardiovascular em pacientes com diabetes mellitus tipo II: Uma Revisão Sistemática

Diniz

Farias

Sousa

2021

RSD

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Introdução: A diabetes mellitus é uma doença cada vez mais prevalente no mundo moderno, sendo altamente relacionada a fatores genéticos e comportamentais e que acarreta em inúmeros problemas de saúde pública. Objetivo: analisar a utilização da vitamina D com o intuito de diminuir o risco cardiovascular em pacientes portadores de diabetes mellitus tipo 2. Métodos: Foi feita uma revisão sistemática da literatura. Para elaboração do estudo, realizou-se busca de dados nacionais e internacionais e sucedeu-se a eleição de critérios de elegibilidade considerando idioma do artigo (inglês e português), textos completos e publicados nos últimos 10 anos. Em sequência, a partir da leitura dos títulos e posterior análise dos resumos, a amostra final constituiu-se de 13 publicações. Resultados: Foi detectado um baixo número de publicações, contudo, constatou-se que a vitamina D e seus análogos têm uma eficácia direta sobre os marcadores utilizados para predizer o risco cardiovascular dos pacientes mesmo possuindo ainda dúvidas sobre seus mecanismos de ação. Conclusões: A intervenção com vitamina D apresenta bons resultados no tocante à diminuição dos marcadores de risco cardiovascular em pacientes diabéticos. Contudo, devem ser realizadas mais pesquisas para melhor esclarecer a correlação dos níveis de vitamina D e a diminuição de eventos cardiovasculares, além de melhor seus mecanismos fisiológicos, estratégias terapêuticas e seus efeitos nos mais diversos perfis populacionais para assim elaborar intervenções eficazes e conclusivas.

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“…These were short term studies mainly focusing on biochemical, immunological and inflammatory markers of vascular damage in patients with 7 vs. -0.9 pg/ml; (p = 0.001)). Furthermore, there was a significant decrease in IL-6, fasting insulin and HOMA-IR in intervention group after 3 months supplementation [90]. Finally, interim results of a small and short-term (6 months) ongoing non-randomized clinical study [91] provided encouraging results.…”

Section: Vitamin D Supplementationmentioning

confidence: 96%

“…VD supplementation significantly reduced serum YKL-40 levels (−22.7 vs. -2.4 ng/ml; ( p value = 0.003)) and MCP-1 (−45.7 vs. -0.9 pg/ml; ( p = 0.001)). Furthermore, there was a significant decrease in IL-6, fasting insulin and HOMA-IR in intervention group after 3 months supplementation [ 90 ]. Finally, interim results of a small and short-term (6 months) ongoing non-randomized clinical study [ 91 ] provided encouraging results.…”

Section: Vitamin D In Diabetic Retinopathymentioning

confidence: 99%

Role of vitamin D in diabetic retinopathy: Pathophysiological and clinical aspects

Tecilazich

Formenti

Giustina

2020

Rev Endocr Metab Disord

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Epidemiological data predict a dramatic increase in the prevalence of diabetes and of diabetic retinopathy (DR)the most common complication of diabetes-for which however we do not have so far effective tools for prevention and treatment. Since hypovitaminosis D is very frequent in patients with diabetes and vitamin D (VD) has vascular protective properties, several studies have addressed the association of VD deficiency with DR and its severity and progression, whereas the effects of VD supplementation on its natural history are largely unknown. Here we review the available evidence that supports the possible protective role of VD in DR and suggests to determine the VD levels in DR patients calling for a definitive randomized clinical trial to ascertain whether VD supplementation could protect against DR.

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Effects of vitamin D supplementation on circulatory YKL-40 and MCP-1 biomarkers associated with vascular diabetic complications: A randomized, placebo-controlled, double-blind clinical trial

Cited by 23 publications

References 34 publications

The impact of vitamin D supplementation on VDR gene expression and body composition in monozygotic twins: randomized controlled trial

The impact of vitamin D supplementation on VDR gene expression and body composition in monozygotic twins: randomized controlled trial

Uso da vitamina D para a diminuição do risco cardiovascular em pacientes com diabetes mellitus tipo II: Uma Revisão Sistemática

Role of vitamin D in diabetic retinopathy: Pathophysiological and clinical aspects

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