Effects of Vitamin E on Susceptibility of Low-Density Lipoprotein and Low-Density Lipoprotein Subfractions to Oxidation and on Protein Glycation in NIDDM

Abstract

Supplementation of vitamin E in NIDDM leads to enrichment of LDL and LDL subfractions and reduced susceptibility to oxidation. Despite a greater percentage increase in vitamin E content in small dense LDL, it remained substantially more susceptible to oxidation than was buoyant LDL. This suggests that dense, LDL may gain less protection against oxidation from antioxidant supplementation than does larger, more buoyant LDL. In contrast to previous reports, vitamin E supplementation did not reduce glycation of intracellular or plasma proteins.

Relationships between plasma measures of oxidative stress and metabolic control in NIDDM

“…It has been shown that whole plasma and isolated LDL from NIDDM patients are more prone to peroxidation as compared to that of control subjects; and that vitamin E supplementation decreased peroxidation of whole plasma as well as isolated lipoprotein fractions [46][47][48]. Diabetic platelets are postulated to be deficient in a -tocopherol and their dysfunction is partially normalised by a -tocopherol therapy [49].…”

β-Carotene affects antioxidant status in non-insulin-dependent diabetes mellitus

“…Indeed, a variety of defects in antioxidative status have been previously reported in experimental and in diabetic patients when compared with a control population [6,7]. Consequently, there is some evidence about the benefit from supplementation of antioxidants (vitamins C and E, probucol and lipoic acid) to patients with diabetes mellitus [8][9][10]. The crucial importance of this topic has been recently presented and discussed at a workshop on antioxidative treatment in diabetes mellitus [11].…”

Effect of supplementation with tomato juice, vitamin E, and vitamin C on LDL oxidation and products of inflammatory activity in type 2 diabetes.

“…Supplementation with vitamin E increases isolated LDL resistance to copper ion oxidation in patients with type 2 diabetes (14,15). However, information is sparse regarding the effects of food products such as tomato juice rather than supplements on the susceptibility of LDL to oxidation and circulating levels of antioxidants and inflammatory products in patients with type 2 diabetes.…”