Effects of VPAC1 activation in nucleus ambiguus neurons

Gherghina, Florin Liviu; Tica, Andrei Adrian; Deliu, Elena; Abood, Mary E.; Brailoiu, G. Cristina; Brǎiloiu, Eugen

doi:10.1016/j.brainres.2016.12.026

Cited by 4 publications

(3 citation statements)

References 38 publications

(62 reference statements)

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“…Cardiac-projecting neurons of the nucleus ambiguus play a critical role in cardiac parasympathetic tone. Their activation elicits bradycardia via acetylcholine release in cardiac ganglia 18 . In addition, a recent study has shown that neurons in the nucleus of the solitary tract are essential for the processing and coordinating respiratory and sympathetic responses to hypoxia 19 .…”

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confidence: 99%

Histopathology of acute colchicine intoxication: novel findings and their association with clinical manifestations

et al. 2022

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A 32-year-old woman attempted suicide by ingesting Gloriosa bulbs and died approximately 2 days later. Toxicological examination revealed a potentially fatal blood concentration of colchicine (0.096 mg/L). In addition to the increased mitotic figures in the gastrointestinal mucosa, a unique finding for acute colchicine intoxication, pathological examination showed microvesicular lipid droplets in the liver, kidney, heart, and conduction system. Furthermore, central chromatolysis of neurons was observed in the pontine nucleus, medial accessory olivary nucleus, nucleus of the solitary tract, and nucleus ambiguus. Grumose degeneration of the cerebellar dentate nucleus was also evident. These pathological findings may help identify colchicine intoxication, even in the absence of evidence suggesting ingestion during autopsy. Moreover, pathological changes in the heart and central nervous system may be associated with the development of serious complications of acute colchicine intoxication.

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confidence: 99%

Histopathology of acute colchicine intoxication: novel findings and their association with clinical manifestations

et al. 2022

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“…Therefore, their activation elicits bradycardia via acetylcholine release in cardiac ganglia. [ 12 ] Additionally, neurons in the nucleus of the solitary tract are essential for processing and coordinating respiratory and sympathetic responses to hypoxia. [ 13 ] These studies indicate that pathological changes in the circulatory and respiratory centers in the medulla oblongata, as observed in the present case, may be strongly associated with the prognosis of acute benzyl alcohol intoxication.…”

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confidence: 99%

Acute benzyl alcohol intoxication: An autopsy case report

et al. 2023

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Introduction: The main mechanism of death and the pathological appearance of cases of benzyl alcohol intoxication has not been fully investigated. Autopsy reports of cases of benzyl alcohol intoxication have not been published. Case presentation: A 24-year-old man was found in the state of cardiopulmonary arrest at a construction site. He had been performing paint stripping. He was immediately transferred to the hospital, but he did not recover. An autopsy showed focal coloring of the skin without any major caustic injury. A histopathological investigation showed vacuolar degeneration in the epidermis and dermo-epidermal junction, and severe erosion of the tracheal and bronchial mucosa. No pathological changes in the kidney were evident. A neuropathological investigation showed central chromatolysis of neuronal cells in pontine nuclei and grumose degeneration in the cerebellar dentate nucleus. The blood content of benzyl alcohol was 780.0 μg/mL. Lessons: Present case suggest that multiple pathways of exposure may be associated with more rapid progression in acute benzyl alcohol intoxication, and that early and/or severe involvement of the central nervous system rather than renal dysfunction may be associated with an early death.

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“…The examination of the synovial fluid may reveal mild inflammation, including an increase in the total number of leukocytes with levels ≤20,000/mm 3 , 40-50% of which being polymorphonuclear (42). Also, neuropeptides such as vasoactive intestinal peptide were found in the synovial fluid of PMR patients which may contribute to the immunomodulation of synovial fluid inflammation, but also extraarticular manifestations such as cardiac rhythm dysregulations (43,44).…”

Section: Laboratory Featuresmentioning

confidence: 99%

Polymyalgia rheumatica: An update (Review)

Florescu,

Bobircă,

Florescu

et al. 2023

Exp Ther Med

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Polymyalgia rheumatica (PMR) is a chronic inflammatory disease which affects the connective vascular tissue, characterized by pain accompanied by morning stiffness, predominantly of the neck muscles, hip and shoulder girdle. Usually, patients with this disease are >50 years of age and biological inflammatory syndrome is present with an increase in both the erythrocyte sedimentation rate and C-reactive protein levels, aspects similar to giant cell arteritis. The aim of the present review was to depict the current pathogenic hypothesis, diagnostic and treatment approach for patients with PMR, and novelties since the development of the currently used 2012 European League Against Rheumatism and American College of Rheumatology provisional classification criteria. PMR is a prevalent disease that can occasionally prove difficult to diagnose and treat. Possibly, the most abundant type of evidence and data revealed over the past decade have been acquired through musculoskeletal imaging, with implications in diagnosis, disease monitoring and relapse, prognosis and changes with treatment. Further research on pathophysiology is required to gain a deeper understanding of the underlying processes, which will serve as the foundation for future personalized treatments. In addition, there is an increasing demand for improved diagnostic techniques, which should include a further development of various imaging modalities, in order to provide accurate diagnosis and appropriate therapy. Contents 1. Introduction 2. Pathogenesis 3. Clinical manifestations 4. Laboratory features 5. Imaging 6. Diagnosis 7. Differential diagnosis 8. Treatment 9. Conclusions and future perspectives

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Effects of VPAC1 activation in nucleus ambiguus neurons

Cited by 4 publications

References 38 publications

Histopathology of acute colchicine intoxication: novel findings and their association with clinical manifestations

Histopathology of acute colchicine intoxication: novel findings and their association with clinical manifestations

Acute benzyl alcohol intoxication: An autopsy case report

Polymyalgia rheumatica: An update (Review)

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