Film cooling is considered a prerequisite for the safe operation of future high-performance rocket engines. Wallnormal or inclined cooling-gas injection into a laminar boundary-layer airflow at Mach 2.6 through a single infinite spanwise slit with various cooling gases using direct numerical simulations and experiments are investigated. Among the investigated gases, helium and hydrogen perform best with respect to cooling effectiveness and skin friction decrease. An arbitrary variation of various cooling-gas parameters shows that the diffusion coefficient has virtually no influence on the cooling effectiveness, whereas low cooling-gas viscosity, low thermal conductivity, high heat capacity, low molar mass, and low density are highly beneficial. In light of this large number of parameters, an extension of the single-species cooling-effectiveness correlation to binary gas-mixture flows is challenging, if possible at all. Nomenclature C = Chapman-Rubesin factor c = mass fraction c f = skin friction coefficient c p = heat capacity at constant pressure c v = heat capacity at constant volume D = ordinary diffusion coefficient D T = thermal diffusion coefficient e = internal energy F = blowing rate I = identity matrix j = diffusion mass-flux vector k = Boltzmann constant L = characteristic length M = molar mass Ma = Mach number Pr = Prandtl number p = pressure q = heat-flux vector R = gas constant Re u = unit Reynolds number Re ∞ = global Reynolds number Sc = Schmidt number T = temperature t = time v = velocity vector X = mole fraction x s = slit position x, y, z = streamwise, spanwise, and wall-normal directions α = blowing angle or thermal diffusion rate η = cooling effectiveness ϑ = thermal conductivity κ = specific heat ratio μ = dynamic viscosity ξ = correlation parameter ϵ = second Lennard-Jones parameter ρ = density σ = first Lennard-Jones parameter Ω = transport collision integral Subscripts c = cooling-gas values (species 2) i = species i is = isothermal uc = uncooled w = values at wall ∞ = freestream values (species 1) Superscripts = Eckert values ⋆ = dimensional values