Effects of walnut oil on lipid profiles in hyperlipidemic type 2 diabetic patients: a randomized, double-blind, placebo-controlled trial

Abstract

Background:The role of herbal medicine is now well documented in preventing and controlling diabetes mellitus. The main aim of this study was to evaluate the effects of walnut oil consumption on lipid profiles of hyperlipidemic patients with type 2 diabetes.Methods:In a randomized, double-blind, placebo-controlled clinical trial, 100 hyperlipidemic type 2 diabetic patients aged 35–75 years were assigned to receive 15 cc Persian walnut oil or placebo every day for 90 days. The primary outcomes were the lipid profiles.Results:Consumption of walnut oil by type 2 hyperlipidemic diabetic patients resulted in a significant decrease in total cholesterol levels (treatment difference (TD)=−30.04, P<0.001), triglyceride (TG) level (TD=−15.04, P=0.021), low-density lipoprotein (LDL) level (TD=−30.44, P<0.001) and total cholesterol to high-density lipoprotein (HDL) ratio (TD=−0.72, P<0.001) compared to the control group. There was a trend toward increasing HDL level with consumption of walnut oil (TD=2.28, P=0.06). Frequency of patients reaching a LDL level below 100 was higher in the case group (20 vs 0%).Conclusions:Addition of walnut oil in the daily diet of type 2 diabetic patients improves lipid profiles. Thus, it may be associated with a coronary artery disease risk factor modulation. Also, walnut oil may serve as a helpful natural remedy for hyperlipidemic patients with type 2 diabetes.

Comparison of the Effects of Brazil Nut Oil and Soybean Oil on the Cardiometabolic Parameters of Patients with Metabolic Syndrome: A Randomized Trial

“…It is known that menopause may contribute to lipid profile alteration [51], but in our study, this effect was not evaluated. Studies evaluating the effects of oil supplementation in patients with chronic diseases present divergent data on lipid profiles; Harris, Hutchins and Fryda [38] showed negative results [38], while others found improvements in these parameters [52][53][54]. These differences among studies may be explained by the different nutritional contexts in which the studies were performed, in addition to the dosage and the period of use of the oils.…”

Metabolic and Blood Pressure Effects of Walnut Supplementation in a Mouse Model of the Metabolic Syndrome

“…The reported effects of walnuts on lipids have been mixed and may also depend on metabolic health. Reductions in total and LDL-cholesterol have been observed in healthy participants [ 6 , 10 , 15 , 19 ] in one study of adults at-risk for diabetes [ 16 ], and a recent randomized control trial of walnut oil in hyperlipidemic DM2 patients [ 20 ]. However, elsewhere, a lack of beneficial effects on lipids in MetS has been reported [ 18 ].…”

Beneficial effects of walnut (Juglans regia L.)&nbsp;oil-derived polyunsaturated fatty acid prevents oxidant status and hyperlipidemia in pregnant rats with diabetes

“…The use of traditional medicine and food derived from medical plants is increasing in the management of multifarious diabetes-associated complications, largely because of the general notion that traditional medicine and food are less adverse effects compared with synthetic drugs [19]. Recent studies have indicated that a walnut oil-rich diet improved type 2 diabetes [13]. However, its protective effects in STZinduced diabetes rats during pregnancy have not been investigated so far.…”

“…Polyunsaturated fatty acids (PUFA), phenolic acids, and avonoids are considered as major active compounds in Juglans regia L. seeds [12]. Recently, clinical researches have indicated that the addition of walnut oil in the daily diet may serve as a helpful remedy for patients with diabetes mellitus type 2 [13,14]. However, whether walnut oil-derived PUFA exhibited bene cial effects against gestational diabetes mellitus is not yet clear.…”