Effects of warm‐supplementing kidney yang (WSKY) capsule added on risperidone on cognition in chronic schizophrenic patients: a randomized, double‐blind, placebo‐controlled, multi‐center clinical trial

Chen, Zhenhua; Wang, Gaohua; Wang, Xiaoping; Ren-yun, Chen; Wang, Huilin; Yang, Minghua; Huo, Yunxiang; Mei, Hongbing

doi:10.1002/hup.958

Cited by 8 publications

(15 citation statements)

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“…Similarly, herbal and natural medicines are also in the early phase of testing but have produced some promising results. Warm-supplementing kidney yang, a Chinese herbal medicine, added to risperidone for 8 weeks has been found to significantly improve social functioning (assessed with the social disability screening schedule) in comparison to a placebo [243]. Omega-3 polyunsaturated fatty acids also show potential for beneficial effects on functional outcome, as evidence shows 3-4 months of adjunctive eicosapentaenoic acid treatment to have beneficial effects on psychopathology [244,245].…”

Section: New Approaches To Intervention Programsmentioning

confidence: 96%

Interventions Targeting Social and Vocational Dysfunction in Individuals with a Schizophrenia Spectrum Disorder

Bartholomeusz

Killackey

Thompson

et al. 2011

Handbook of Schizophrenia Spectrum Disorders, Volume III

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Individuals with a schizophrenia spectrum disorder are among the most marginalized of any chronic illness group, having poorer performance and outcomes in nearly every domain of health and functioning. Poor social functioning is now widely acknowledged to be a major indicator of the prognosis of schizophrenia as well as a major contributor to illness outcome. Social and functional disabilities have serious detrimental effects on the individuals' quality of life and recovery, yet up until the twenty-first century treatment had largely been concentrated around symptomatic improvement, with the assumption that functional recovery would automatically follow. However, statistics on functional outcomes for individuals with schizophrenia and other psychotic illnesses suggest that this is in fact a relatively rare phenomenon. The definitions of "functioning" and "outcome" have also been poorly defined and inconsistent over the years, with alleviation of psychotic symptoms and decreased hospital admissions weighing heavily in the characterisation of improved functional outcome. In the last decade most studies have included a general measure of global functioning and/or education/employment as an indicator, but these performance measures have generally not been the primary topic of interest. Only recently has the incorporation of "social" functioning (i.e. social competence, independent living, community involvement and interpersonal relationships), been included as an important factor in overall outcome and moved into the spotlight as a major target for intervention. Historically, social skills training and cognitive remediation have been used to target deficits in social behaviour and cognition, respectively. However, new intervention strategies are being designed to target the underlying thinking patterns related to social interaction, termed social cognition. This chapter will review the different types of interventions that have been or are currently used to treat social and occupational

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Section: New Approaches To Intervention Programsmentioning

confidence: 96%

Interventions Targeting Social and Vocational Dysfunction in Individuals with a Schizophrenia Spectrum Disorder

Bartholomeusz

Killackey

Thompson

et al. 2011

Handbook of Schizophrenia Spectrum Disorders, Volume III

View full text Add to dashboard Cite

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“…The ayurvedic group had less weight gain ( Mundewadi et al, 2008 ). Two large studies by Chen et al (2008a , 2008b , 2009) of a mixture of 13 Chinese herbs found an improvement on general psychopathology. When kidney yang was added to risperidone, an improvement on cognitive and depressive symptoms was found in one study (from two) ( Chen et al, 2008a , 2009 ).…”

Section: Reviewmentioning

confidence: 98%

“…Many studies on Eastern herbs were found, but only six had a Jadad score of three or higher ( Chen et al, 2008a , 2008b , 2009 ; Mahal et al, 1976 ; Mundewadi et al, 2008 ; Naidoo, 1956 ). One old study on reserpine found “clinical improvement” after 11 weeks compared with placebo in 80 patients not treated with antipsychotics but with electroconvulsice therapy ( Naidoo, 1956 ).…”

Section: Reviewmentioning

confidence: 99%

“…Another old study ( Mahal et al, 1976 ) found positive effects of brahmyadiyoga without antipsychotics compared with placebo and equal to chlorpromazin in 136 patients with schizophrenia ( Mahal et al, 1976 ); no adverse effects were reported. Four (from six) more recent studies found significant effects on general psychopathology when adding ayurvedic herbs (reserpine: one study [ Naidoo, 1956 ]; bacopa monnieri and nardostachys jatamansi: one study [ Mundewadi et al, 2008 ]; a mixture of 13 Chinese herbs: two studies [ Chen et al, 2008a , 2008b , 2009 ]) to antipsychotics.…”

Section: Reviewmentioning

confidence: 99%

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Natural Medicines for Psychotic Disorders

Hoenders¹,

Bartels-Velthuis²,

Vollbehr³

et al. 2018

J Nerv Ment Dis

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Patients with psychotic disorders regularly use natural medicines, although it is unclear whether these are effective and safe. The aim of this study was to provide an overview of evidence for improved outcomes by natural medicines. A systematic literature search was performed through Medline, PsycINFO, CINAHL, and Cochrane until May 2015. In 110 randomized controlled trials, evidence was found for glycine, sarcosine, N-acetylcysteine, some Chinese and ayurvedic herbs, ginkgo biloba, estradiol, and vitamin B6 to improve psychotic symptoms when added to antipsychotics. Ginkgo biloba and vitamin B6 seemed to reduce tardive dyskinesia and akathisia. Results on other compounds were negative or inconclusive. All natural agents, except reserpine, were well tolerated. Most study samples were small, study periods were generally short, and most results need replication. However, there is some evidence for beneficial effects of certain natural medicines.

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“…Herbal prescriptions, such as WSKY or strong kidney yin, are considered to improve deficits associated with schizophrenia. Previously, it was reported that WSKY capsules in addition to risperidone significantly enhanced cognitive function, social function (6) and improved the quality of life (7) compared with the placebo added to risperidone. The present study focused on the mechanisms underlying WSKY's effects on cognition enhancement.…”

Section: Introductionmentioning

confidence: 99%

WSKY, a traditional Chinese decoction, rescues cognitive impairment associated with NMDA receptor antagonism by enhancing BDNF/ERK/CREB signaling

Guo

Chen

Wang

et al. 2014

Molecular Medicine Reports

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Warm‑supplementing kidney yang (WSKY) is an herbal prescription that has been used in Traditional Chinese Medicine for the treatment of psychiatric conditions. A previous study by our group found that WSKY significantly improved cognitive function of schizophrenia patients. In the present study, the effects of WSKY on cognitive function and their underlying mechanisms were investigated. WSKY was administered to an MK‑801‑induced rat model of chronic schizophrenia for 14 days. Memory performance was assessed using the Morris water maze (MWM) test. The expression of brain‑derived neurotrophic factor (BDNF), activation of cAMP response element binding protein (pCREB/CREB) and activation of extracellular signal‑regulated kinase (pERK/ERK) in the hippocampus was detected using western blot analysis. In the acquisition phase of the MWM test, the escape latency was significantly increased in the MK‑801‑treated group compared with the normal control group (P<0.01). Treatment with WSKY for 14 days at doses of 100 or 250 mg/kg rescued this cognitive impairment (P<0.05). In the probe test, 250 mg/kg WSKY treatment increased the time spent in the target quadrant (P<0.05) and number of platform crossings (P<0.01). Western blot analysis demonstrated that the levels of BDNF expression in the hippocampus of rats without behavioral tests were elevated following 14 days of WSKY treatment, and the effect of WSKY treatment on hippocampal BDNF expression was presented in an inverted U‑shaped dose‑response pattern. The pERK1/2 in the hippocampus was significantly enhanced following 100 mg/kg (P<0.01) and 250 mg/kg (P<0.01) WSKY treatment, while only 250 mg/kg WSKY increased the phosphorylation of CREB (P<0.01). The results of the present study indicated that WSKY enhances cognitive performance via the upregulation of BDNF/ERK/CREB signaling, and that WSKY has potential therapeutic implications for cognitive impairment of schizophrenia.

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Effects of warm‐supplementing kidney yang (WSKY) capsule added on risperidone on cognition in chronic schizophrenic patients: a randomized, double‐blind, placebo‐controlled, multi‐center clinical trial

Abstract: WSKY capsule added on risperidone may improve cognitive function, social function of the chronic schizophrenic patients, and the WSKY safely during treatment.

Cited by 8 publications

References 5 publications

Interventions Targeting Social and Vocational Dysfunction in Individuals with a Schizophrenia Spectrum Disorder

Interventions Targeting Social and Vocational Dysfunction in Individuals with a Schizophrenia Spectrum Disorder

Natural Medicines for Psychotic Disorders

WSKY, a traditional Chinese decoction, rescues cognitive impairment associated with NMDA receptor antagonism by enhancing BDNF/ERK/CREB signaling

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