Effects of Washed Fecal Bacteria Transplantation in Sleep Quality, Stool Features and Autism Symptomatology: A Chinese Preliminary Observational Study

Zhang, Yiting; Zhang, Jing; Pan, Zhao-Yu; He, Xiaofu

doi:10.2147/ndt.s355233

Cited by 10 publications

(5 citation statements)

References 46 publications

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“…This is supported by previous research that shows a link between GI and ASD severity, but from these data it was not possible to ascertain a causative effect (Babinska et al, 2020). In addition, Zhang et al found a greater positive effect on ASD severity in children who were not constipated than for those who were constipated prior to FMT (Zhang et al, 2022). The authors suggested that, in children who have preexisting GI symptoms, FMT may better improve ASD symptom severity if the children's GI problems are treated first.…”

Section: Association Between Gastrointestinal Symptoms and Autism Spe...mentioning

confidence: 68%

“…Figure 1 shows the treatment regimens used in human trials. Two additional studies also demonstrated that the effect of FMT on the severity of ASD symptoms increased with increasing treatment courses (Pan et al, 2022;Zhang et al, 2022). This evidence suggests that prolonged treatment, or multiple courses, may achieve longerlasting benefits for children with ASD.…”

Section: Recent Studies Evaluating the Effectiveness Of Fecal Microbi...mentioning

confidence: 90%

“…FMT significantly improves GI symptoms for children with ASD (Kang et al, 2017;Kang et al, 2019;Li et al, 2021;Pan et al, 2022;Zhang et al, 2022). Indigestion, diarrhea, abdominal pain, and constipation were all significantly improved relative to baseline across multiple studies, alongside a reduction in the number of days where participants experienced abnormal or no stools (Kang et al, 2017;Kang et al, 2019;Li et al, 2021;Pan et al, 2022).…”

Section: Association Between Gastrointestinal Symptoms and Autism Spe...mentioning

confidence: 93%

“…Studies demonstrate that FMT significantly improves behavioral symptoms of ASD. Two open-label clinical trials and two retrospective studies found that post-intervention with FMT, ASD severity was significantly reduced relative to baseline when measured using the Childhood Autism Rating Scale (CARS) (Kang et al, 2017;Kang et al, 2019;Li et al, 2021;Pan et al, 2022;Zhang et al, 2022). The CARS is conducted by a professional evaluator and has previously been reported as a valid diagnostic tool with good sensitivity and specificity (Chlebowski et al, 2010).…”

Section: Recent Studies Evaluating the Effectiveness Of Fecal Microbi...mentioning

confidence: 99%

“…The studies vary with their use of preparatory procedures such as antibiotic treatment, proton pump inhibitors, bowel clenses, and the size and number of doses/courses of FMT delivered. The information included in this figure has been obtained/adapted from (Kang et al, 2017;Zhang et al, 2022;Pan et al, 2022;Li et al, 2021) FMT, fecal microbial transplantation.…”

Section: Restructuring the Microbiotamentioning

confidence: 99%

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Fecal microbial transplantation as a novel therapeutic for autism spectrum disorders: a review of the current literature

Gudka

Nyinoh

2023

Front. Microbiomes

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BackgroundAutism spectrum disorders (ASDs) are complex neurobiological conditions with poor long-term outcomes and limited treatment options. The microbiota–gut–brain axis indicates a pathway by which the gut microbiota links to ASDs. Fecal microbial transplantation (FMT), whereby the gut microbiota is replaced with that of a healthy individual, shows promise for the treatment of neurobiological conditions. This review examines the current evidence for the use of FMT as a therapeutic for ASD.DiscussionASDs and their associated gastrointestinal symptoms are improved with FMT, potentially due to the engraftment of features of a healthy gut. Longer treatment regimens that include daily maintenance doses appear to be the most effective long-term therapeutic option, with benefits persisting 2 years post-intervention. Evidence is mixed regarding the use of preparatory treatments. Considering the sex bias in ASD research, small sample sizes and the lack of placebo control arms, randomized controlled trials would be of benefit to the evidence base regarding the use of FMT as a therapeutic option for ASD.ConclusionFMT is a promising new therapeutic for ASD, but the evidence base is in its infancy.

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Section: Association Between Gastrointestinal Symptoms and Autism Spe...mentioning

confidence: 68%

Section: Recent Studies Evaluating the Effectiveness Of Fecal Microbi...mentioning

confidence: 90%

Section: Association Between Gastrointestinal Symptoms and Autism Spe...mentioning

confidence: 93%

Section: Recent Studies Evaluating the Effectiveness Of Fecal Microbi...mentioning

confidence: 99%

Section: Restructuring the Microbiotamentioning

confidence: 99%

See 3 more Smart Citations

Fecal microbial transplantation as a novel therapeutic for autism spectrum disorders: a review of the current literature

Gudka

Nyinoh

2023

Front. Microbiomes

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Effect of oral faecal microbiota transplantation intervention for children with autism spectrum disorder: A randomised, double‐blind, placebo‐controlled trial

Wan,

Wang,

Liang

et al. 2024

Clinical & Translational Med

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To the Editor:We conducted a randomised, double-blind, placebocontrolled trial of an oral faecal microbiota transplantation (FMT) intervention in children with autism spectrum disorder (ASD), and observed that there were differences in pre-and post-FMT intervention changes in the social domain scores of the Vineland Adaptive Behaviour Scale, third version (Vineland-3), with no severe adverse events (AEs) related to FMT occurring.Multiple studies have documented variations in the gut microbiota (GM) between children with ASD and typically developing children. 1,2 Furthermore, specific gut microbes may modulate ASD-related behaviour through their metabolites. 1 However, another study proposed that the GM is not the central driver of ASD symptoms; rather, the presence of restricted interests associated with ASD and a more limited dietary variety have been linked to reduced diversity in the GM. 3 The relationship between the GM and ASD remains enigmatic and complex as the age-old philosophical conundrum that has long been debated: which came first, the chicken or the egg? Some open-label studies 4-6 have demonstrated that FMT improved the core symptoms of patients with ASD, though these studies lacked comparable control groups, which may lead to disregard of potential placebo effects on efficacy evaluation. Therefore, we conducted this study.A total of 103 eligible participants (Figure 1) were enrolled and randomised to receive either FMT or a placebo. These agents were administered during two 6day periods in the hospital, the first occurring in the initial week and the second in the fifth week of the study. Patients were not hospitalised during the interval between treatments. FMT capsules from five healthy donors were

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Fecal microbiota transplants in pediatric autism: opportunities and challenges

Wang,

Yang,

Zhong

et al. 2024

World J Pediatr

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Effects of Washed Fecal Bacteria Transplantation in Sleep Quality, Stool Features and Autism Symptomatology: A Chinese Preliminary Observational Study

Cited by 10 publications

References 46 publications

Fecal microbial transplantation as a novel therapeutic for autism spectrum disorders: a review of the current literature

Fecal microbial transplantation as a novel therapeutic for autism spectrum disorders: a review of the current literature

Effect of oral faecal microbiota transplantation intervention for children with autism spectrum disorder: A randomised, double‐blind, placebo‐controlled trial

Fecal microbiota transplants in pediatric autism: opportunities and challenges

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