Effects of water-filtered infrared-A and of heat on cell death, inflammation, antioxidative potential and of free radical formation in viable skin – First results

Piazena, Helmut; Pittermann, W.; Müller, W.; Jung, K.; Kelleher, Debra K.; Herrling, T.; Meffert, Peter J.; Uebelhack, Ralf; Kietzmann, Manfred

doi:10.1016/j.jphotobiol.2014.06.007

Cited by 16 publications

(22 citation statements)

References 33 publications

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“…Some studies have shown that there is an increase in collagen degradation and ROS generation with a relatively small increase in temperature. Piazena et al studied the effects of water-filtered infrared-A (wIRA) with convective cooling or heating on viability, inflammation, inducible free radicals and antioxidant enzyme content in natural and viable skin [6]. The water-filtered IR-A, applied over 30 minutes to the skin at an irradiance of 190 mW/cm 2 , with the skin temperature maintained at 37°C by convective cooling from air ventilation, did not significantly affect the cell viability, the inflammatory status, the free radical content, or the antioxidant defense systems of the skin.…”

Section: Nir and Skinmentioning

confidence: 99%

Infrared and skin: Friend or foe

Barolet

Christiaens²,

Hamblin

2016

Journal of Photochemistry and Photobiology B: Biology

187

168

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In the last decade, it has been proposed that the sun's IR-A wavelengths might be deleterious to human skin and that sunscreens, in addition to their desired effect to protect against UV-B and UV-A, should also protect against IR-A (and perhaps even visible light). Several studies showed that NIR may damage skin collagen content via an increase in MMP-1 activity in the same manner as is known for UVR. Unfortunately, the artificial NIR light sources used in such studies were not representative of the solar irradiance. Yet, little has been said about the other side of the coin. This article will focus on key information suggesting that IR-A may be more beneficial than deleterious when the skin is exposed to the appropriate irradiance/dose of IR-A radiation similar to daily sun exposure received by people in real life. IR-A might even precondition the skin – a process called photoprevention - from an evolutionary standpoint since exposure to early morning IR-A wavelengths in sunlight may ready the skin for the coming mid-day deleterious UVR. Consequently IR-A appears to be the solution, not the problem. It does more good than bad for the skin. It is essentially a question of intensity and how we can learn from the sun.

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Section: Nir and Skinmentioning

confidence: 99%

Infrared and skin: Friend or foe

Barolet

Christiaens²,

Hamblin

2016

Journal of Photochemistry and Photobiology B: Biology

187

168

View full text Add to dashboard Cite

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“…Piazena et al [31] have shown that wIRA exposure did not generate measurable cell death or inflammation in the tissue even if an irradiance of 190 mW cm À2 within 780-1400 nm (equivalent to 240 mW cm À2 within 590-1400 nm) was applied during a treatment time of 30 min. Moreover, only convective heating by air flow, but not heating by wIRA increased significantly the number of free radicals in skin.…”

Section: Photobiological Basis Of Tissue Heating By Wiramentioning

confidence: 99%

Biophysical and photobiological basics of water-filtered infrared-A hyperthermia of superficial tumors

Vaupel

Piazena

Müller³

et al. 2018

International Journal of Hyperthermia

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Thermography-controlled, water-filtered infrared-A (wIRA) is a novel, effective and approved heating technique listed in the ESHO quality assurance guidelines for superficial hyperthermia clinical trials (2017). In order to assess the special features and the potential of wIRA-hyperthermia (wIRA-HT), detailed and updated information about its physical and photobiological background is presented. wIRA allows for (a) application of high irradiances without skin pain and acute grade 2-4 skin toxicities, (b) prolonged, therapeutically relevant exposure times using high irradiances (150-200 mW/cm 2 ) and (c) faster and deeper heat extension within tissues. The deeper radiative penetration depth is mainly caused by forward Mie-scattering. At skin surface temperatures of 42-43 C, the effective heating depth is 15 mm (T ! 40 C) and 20 mm (T ! 39.5 C). Advantages of wIRA include its contact-free energy input, easy power steering by a feed-back loop, extendable treatment fields, real-time and noninvasive surface temperature monitoring with observation of dynamic changes during HT, and -if necessaryrapid protection of temperature-sensitive structures. wIRA makes the compliant heating of ulcerated and/or bleeding tumors possible, allows for HT of irregularly shaped and diffusely spreading tumors, is independent of individual body contours, allows for very short 'transits' between HT and RT (1-4 min) or continuous heating between both therapeutic interventions. New treatment options for wIRA-HT may include malignant melanoma, vulvar carcinoma, skin metastases of different primary tumors, cutaneous T-and B-cell lymphoma, large-area hemangiomatosis, inoperable squamous cell, basal cell and eccrine carcinoma of the skin with depth extensions 20 mm. ARTICLE HISTORY

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“…Our results were surprising, as 17 of the 20 patients did not develop any skin lesions when exposed to light from which infrared radiation had been blocked. Animal model studies have shown that skin exposure to filtered infrared radiation, blocked by water, significantly reduces the skin's antioxidative defense systems (15). According to Akhalaya el al, infrared radiation is capable of generating oxidative stress both directly (through the radiation itself) and indirectly (through the heat it generates) (16).…”

Section: Discussionmentioning

confidence: 99%

Water‐Filtered Infrared Radiation Decreases the Generation of Photodermatoses Dependent on Ultraviolet and Visible Radiation

Gálvez

Aguilera

Sánchez‐Roldán

et al. 2018

Photochem & Photobiology

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The potential role of infrared radiation in photodermatoses has received very little attention, even though the main sources of radiation used for photobiological studies (UVA, UVB and visible light) include infrared radiation. The objective of the work was to assess whether infrared radiation is involved in the development of skin lesions in patients with different types of photodermatoses. Twenty patients with different photodermatoses were exposed to UVA, UVB and visible radiation using a high‐pressure mercury UVA lamp, a fluorescent broadband UVB lamp, a tungsten bulb and a slide projector for visible radiation. Part of the radiation emitted by these lamps was water‐filtered to block infrared radiation above 1300 nm. All 20 patients developed lesions when exposed to different light sources used for phototest. When exposed to same sources without infrared radiation, 17 patients (85%) did not develop any lesions and the other three (15%) developed less severe lesions than in the area exposed to unfiltered light. Our results show that infrared radiation was necessary for the development of skin lesions in 85% of the patients with photodermatoses in our study. We believe that infrared radiation studies should be included in standard photobiology protocols.

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Effects of water-filtered infrared-A and of heat on cell death, inflammation, antioxidative potential and of free radical formation in viable skin – First results

Cited by 16 publications

References 33 publications

Infrared and skin: Friend or foe

Infrared and skin: Friend or foe

Biophysical and photobiological basics of water-filtered infrared-A hyperthermia of superficial tumors

Water‐Filtered Infrared Radiation Decreases the Generation of Photodermatoses Dependent on Ultraviolet and Visible Radiation

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