Effects of Weight Loss after Bariatric Surgery for Morbid Obesity on Vascular Endothelial Growth Factor-A, Adipocytokines, and Insulin

Torre, Nuria García de la; Rubio, Miguel A.; Bordiú, Elena; Cabrerizo, Lucio; Aparicio, Eugenio; Hernández, Carmen; Sánchez‐Pernaute, Andrés; Díez-Valladares, Luis; Torres, Antonio; Puente, Montserrat; Charro, Aniceto

doi:10.1210/jc.2007-1370

Cited by 111 publications

(105 citation statements)

References 39 publications

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“…Our investigation corroborates preliminary studies (18,(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31) as it shows that obesity is a state of chronic low-grade inflammation and the weight reduction resulting from bariatric surgery significantly improves the inflammatory state. This amelioration relies on the continuous reduction in hs-CRP and IL-6 concentrations, associated with a parallel decrease in BMI.…”

Section: Discussionsupporting

confidence: 91%

“…Previous studies have demonstrated that surgically induced weight loss is accompanied by an improvement of the endothelial function (18,19,21) and the proinflammatory state (18,(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31). However, few studies have studied endothelial function and proinflammatory state together, and have considered different time-points to determine postsurgical changes.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Obesity, endothelial function and inflammation: the effects of weight loss after bariatric surgery

Gómez¹,

Ortega²,

Aragón‐Alonso³

et al. 2016

Nutr Hosp

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Palabras clave:Obesidad. Cirugía bariátrica. Infl amación. Función endotelial. Resistencia a la insulina. ResumenObjetivo: la obesidad está asociada con un aumento del riesgo de enfermedad cardiovascular. Se ha propuesto una relación causal entre obesidad, infl amación, resistencia a la insulina, y disfunción endotelial. El objetivo de este estudio fue valorar marcadores de insulinorresistencia, infl amación y disfunción endotelial en pacientes con obesidad mórbida antes y después de la pérdida de peso por cirugía bariátrica. Métodos: se midieron las concentraciones séricas de moléculas solubles de adhesión intercelular tipo 1 (sICAM-1), inhibidor del activador del plasminógeno tipo 1 (PAI-1), proteína C reactiva de alta sensibilidad (hs-PCR) e interleucina 6 (IL-6) en 79 pacientes con obesidad mórbida antes y a los 3, 6 y 12 meses de la realización de un by-pass gástrico. También se evaluaron índices de resistencia a la insulina. Resultados: a los 12 meses de la cirugía disminuyeron los niveles de sICAM1 (p < 0,001), PAI-1 (p < 0,05), hs-CRP (p < 0,001), IL-6 (p < 0,001) y el índice homeostasis model assessment (HOMA) (p < 0,001) y aumentó el índice McAuley (p < 0,001). Los niveles basales de hs-PCR estaban correlacionados con los de sICAM-1 (r = 0,450, p < 0,01) y de IL-6 (r = 0,451, p < 0,01). También existía correlación entre el descenso de los niveles de PAI-1 y el descenso de hs-PCR (r = 0,425, p < 0,01) y triglicéridos (r = 0,351, p < 0,01). Conclusiones: en pacientes con obesidad mórbida una importante pérdida de peso por cirugía bariátrica se acompaña de una mejora signifi cativa de marcadores infl amatorios, de función endotelial e insulinorresistencia, lo que puede suponer una disminución del riesgo cardiovascular. Existe una relación entre mejora del perfi l infl amatorio y función endotelial. AbstractObjective: Obesity is associated with a high risk for atherosclerotic cardiovascular disease. There is a causal association between obesity, infl ammation, insulin resistance (IR) and endothelial dysfunction. The aim of this study was to evaluate changes in IR, proinfl ammatory state and markers of endothelial dysfunction in morbidly obese patients after weight loss following bariatric surgery. Methods: In this study, we measured the levels of soluble intracellular adhesion molecule-1 (sICAM1), plasminogen activator inhibitor 1 (PAI-1), high-sensitivity C-reactive protein (hs-CRP), and interleukin-6 (IL-6) in 79 morbidly obese patients at baseline and 3, 6 and 12 months after gastric bypass. Also, we evaluated changes in IR. Results: Twelve months after surgery, there was a signifi cant decrease in plasma levels of sICAM1 (p < 0.001), PAI-1 (p < 0.05), hs-CRP (p < 0.001), IL-6 (p < 0.001) and homeostasis model assessment (HOMA) (p < 0.001) and a signifi cant increase of McAuley index (McAuley) (p < 0.001). Baseline levels of hs-PCR were positively correlated with sICAM-1 (r = 0.450, p < 0.01) and IL-6 (r = 0.451, p < 0.01). Signifi cant correlations were also found between the decrease of PAI-1 and the ...

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Obesity, endothelial function and inflammation: the effects of weight loss after bariatric surgery

Gómez¹,

Ortega²,

Aragón‐Alonso³

et al. 2016

Nutr Hosp

View full text Add to dashboard Cite

show abstract

“…This association was still evident in models with BMI adjustment, pointing to a direct, adiposity-independent effect on insulin action. The protein encoded by VEGFA is known to be involved in adipogenesis, and raised levels of serum VEGFA have previously been shown to be associated with overweight and obesity [17,18]. A German study of 1,578 non-diabetic individuals reported that a variant (rs9472138 T allele) in VEGFA was associated with increased insulin secretion [19].…”

Section: Discussionmentioning

confidence: 99%

Association studies of novel obesity-related gene variants with quantitative metabolic phenotypes in a population-based sample of 6,039 Danish individuals

et al. 2011

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Aims/hypothesis Genome-wide association studies have identified novel WHR and BMI susceptibility loci. The aim of this study was to elucidate if any of these loci had an effect on quantitative measures of glucose homeostasis, including estimates of insulin release and insulin sensitivity in an epidemiological setting. Methods By applying an additive genetic model, 14 WHRassociated gene variants and 18 BMI-associated variants were investigated for their relationships with glucoserelated metabolic traits in treatment-naive individuals from the population-based Inter99 study sample (n=6,039). Results Of the variants associated with BMI, the QPCTL rs2287019 C allele was associated with an increased insulinogenic index of 7.4% per risk allele (p=4.0×10 ) and increased disposition index of 5.6% (p=6.4×10 −5). The LRP1B rs2890652 C allele was associated with insulin resistance, showing a 3.3% increase (p=0.0011) using the HOMA-insulin resistance (HOMA-IR) index and a 2.2% reduction (p=0.0014) with the Matsuda index. Of the variants associated with WHR, LYPLAL1/SLC30A10 rs4846567 G allele carriers showed a 5.2% lower HOMA-IR (p=0.00086) in women, indicating improved insulin sensitivity. Female carriers of the VEGFA rs6905288 A allele were insulin resistant, with a 3.7% increase in HOMA-IR (p=0.00036) and 4.0% decrease in Matsuda index (p=2×10 −4).Electronic supplementary material The online version of this article (doi:10.1007/s00125-011-2320-4) contains peer-reviewed but unedited supplementary material, which is available to authorised users. Conclusions Our correlative findings from analysing single-locus data suggest that some variation in validated BMI and WHR loci are associated with either increased or decreased insulin sensitivity and thereby potentially with metabolically healthy or metabolically unhealthy subsets of obesity. The results call for testing in larger study samples and for further physiological exploration of the possible metabolic implications of these loci. K. S. Burgdorf (*):

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“…31 Leptin levels decrease significantly after bariatric surgery in proportion to loss of total body fat. 68 Furthermore, a decrease in leptin after bariatric surgery was inversely correlated with increased levels of markers of bone formation and resorption. The increment in markers of resorption, however, significantly exceeded that of markers of formation indicating a tipping of the balance toward bone loss.…”

Section: Impact Of Bariatric Surgery On Bone Metabolismmentioning

confidence: 97%

Bariatric surgery and bone disease: from clinical perspective to molecular insights

et al. 2012

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Effects of Weight Loss after Bariatric Surgery for Morbid Obesity on Vascular Endothelial Growth Factor-A, Adipocytokines, and Insulin

Abstract: Serum VEGF-A levels are significantly higher in obese patients than in lean controls, decreasing after weight loss with bariatric surgery, behaving similarly to other hormones related to adipose mass like leptin and insulin.

Cited by 111 publications

References 39 publications

Obesity, endothelial function and inflammation: the effects of weight loss after bariatric surgery

Obesity, endothelial function and inflammation: the effects of weight loss after bariatric surgery

Association studies of novel obesity-related gene variants with quantitative metabolic phenotypes in a population-based sample of 6,039 Danish individuals

Bariatric surgery and bone disease: from clinical perspective to molecular insights

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